American Journal of Cardiology
Volume 105, Issue 1 , Pages 54-58 , 1 January 2010

Effect of Quinapril on In-Stent Restenosis and Relation to Plasma Apoptosis Signaling Molecules

  • Spyridon Deftereos, MD

      Affiliations

    • Department of Cardiology, Athens General Hospital, Athens, Greece
  • ,
  • Georgios Giannopoulos, MD

      Affiliations

    • Department of Cardiology, Athens General Hospital, Athens, Greece
  • ,
  • Charalampos Kossyvakis, MD

      Affiliations

    • Department of Cardiology, Athens General Hospital, Athens, Greece
  • ,
  • Andreas Kaoukis, MD

      Affiliations

    • Department of Cardiology, Athens General Hospital, Athens, Greece
  • ,
  • Konstantin Raisakis, MD

      Affiliations

    • Department of Cardiology, Athens General Hospital, Athens, Greece
  • ,
  • Metaxia Driva, MD

      Affiliations

    • Department of Cardiology, Athens General Hospital, Athens, Greece
  • ,
  • Vasiliki Panagopoulou, MD

      Affiliations

    • Department of Cardiology, Athens General Hospital, Athens, Greece
  • ,
  • Spyridon Lappos, MD

      Affiliations

    • Department of Cardiology, Athens General Hospital, Athens, Greece
  • ,
  • Ilias Rentoukas, MD

      Affiliations

    • Department of Cardiology, A. Fleming General Hospital, Melissia, Greece
  • ,
  • Vlasios Pyrgakis, MD

      Affiliations

    • Department of Cardiology, Athens General Hospital, Athens, Greece
  • ,
  • Martin A. Alpert, MD

      Affiliations

    • Division of Cardiology, University of Missouri–Columbia School of Medicine, Columbia, Missouri
    • Corresponding Author InformationCorresponding author: Tel: 573-882-2296; fax: 573-884-7743

Received 2 May 2009 ,Revised 11 August 2009 ,Accepted 11 August 2009.

  • Image Result

    Scatterplots of the differences between baseline and follow-up values of sFas and sFasL plasma levels in the quinapril and the control groups. Positive values denote increases in plasma apoptotic sign

    Scatterplots of the differences between baseline and follow-up values of sFas and sFasL plasma levels in the quinapril and the control groups. Positive values denote increases in plasma apoptotic signaling molecule levels. Note that substantially more patients in the quinapril group experienced increases in plasma sFas and sFasL levels 6 months after stenting than in the placebo group.

  • Image Result
    Relation of change in plasma sFas levels to late luminal loss in the quinapril and placebo groups. In quinapril-treated patients, there was a significant negative correlation between the change in pla

    Relation of change in plasma sFas levels to late luminal loss in the quinapril and placebo groups. In quinapril-treated patients, there was a significant negative correlation between the change in plasma sFas levels obtained from the left anterior descending coronary artery and late luminal loss (r = −0.14, p = 0.015). No such correlation was observed in the placebo group.

PII: S0002-9149(09)02213-9

doi: 10.1016/j.amjcard.2009.08.648

American Journal of Cardiology
Volume 105, Issue 1 , Pages 54-58 , 1 January 2010