American Journal of Cardiology
Volume 105, Issue 1 , Pages 25-28 , 1 January 2010

Prognosis After Change in Left Ventricular Ejection Fraction During Mental Stress Testing in Patients With Stable Coronary Artery Disease

  • Michael A. Babyak, PhD

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina
    • Corresponding Author InformationCorresponding author: Tel: 919-684-3828; fax: 919-684-8629
  • ,
  • James A. Blumenthal, PhD

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina
  • ,
  • Alan Hinderliter, MD

      Affiliations

    • Department of Medicine, University of North Carolina Hospitals, Chapel Hill, North Carolina
  • ,
  • Benson Hoffman, PhD

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina
  • ,
  • Robert A. Waugh, MD

      Affiliations

    • Department of Medicine, Duke University Medical Center, Durham, North Carolina
  • ,
  • R. Edward Coleman, MD

      Affiliations

    • Department of Radiology, Duke University Medical Center, Durham, North Carolina
  • ,
  • Andrew Sherwood, PhD

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina

Received 20 May 2009 ,Revised 7 August 2009 ,Accepted 7 August 2009.

References 

  1. Jiang W, Babyak M, Krantz DS, Waugh RA, Coleman RE, Hanson MM, et al. Mental stress–induced myocardial ischemia and cardiac events. JAMA. 1996;275:1651–1656
  2. Jain D, Burg M, Soufer R, Zaret BL. Prognostic implications of mental stress-induced silent left ventricular dysfunction in patients with stable angina pectoris. Am J Cardiol. 1995;76:31–35
  3. Sheps DS, McMahon RP, Becker L, Carney RM, Freedland KE, Cohen JD, et al. Mental stress-induced ischemia and all-cause mortality in patients with coronary artery disease: results from the psychophysiological investigations of myocardial ischemia study. Circulation. 2002;105:1780–1784
  4. Krantz DS, Santiago HT, Kop WJ, Bairey Merz CN, Rozanski A, Gottdiener JS. Prognostic value of mental stress testing in coronary artery disease. Am J Cardiol. 1999;84:1292–1297
  5. Pilote L, Miller DP, Califf RM, Rao JS, Weaver WD, Topol EJ. Determinants of the use of coronary angiography and revascularization after thrombolysis for acute myocardial infarction. N Engl J Med. 1996;335:1198–1205
  6. Blumenthal JA, Sherwood A, Babyak MA, Watkins LL, Waugh R, Georgiades A, et al. Effects of exercise and stress management training on markers of cardiovascular risk in patients with ischemic heart disease: a randomized controlled trial. JAMA. 2005;293:1626–1634
  7. Blumenthal JA, Jiang W, Waugh RA, Frid DJ, Morris JJ, Coleman RE, et al. Mental stress-induced ischemia in the laboratory and ambulatory ischemia during daily life (Association and hemodynamic features). Circulation. 1995;92:2102–2108
  8. Metler FA, Guiberteau MJ. Cardiovascular system. In:  Metler FA,  Guiberteau MJ editor. Essentials of Nuclear Imaging. Orlando: Grune & Stratton; 1986;p. 151–152
  9. Cox DR. Regression models and life tables. J R Stat Soc Series B Stat Methodol. 1972;34:187–220
  10. Harrell FE. Regression Modeling Strategies: With Applications to Linear Modeling, Logistic Regression, and Survival Analysis. In: New York: Springer; 2001;p. 568
  11. Stone CJ, Koo CY. Additive Splines in Statistics (Proceedings of the Statistical Computing Section). Washington, DC: American Statistical Association; 1985;
  12. Sherwood A, Turner JR. Hemodynamic responses during psychological stress: implications for studying disease processes. Int J Behav Med. 1995;2:193–218
  13. Dakak N, Quyyumi AA, Eisenhofer G, Goldstein DS, Cannon RO. Sympathetically mediated effects of mental stress on the cardiac microcirculation of patients with coronary artery disease. Am J Cardiol. 1995;76:125–130
  14. Vetrovec GW. Changing concepts in the pathophysiology of myocardial ischemia. Am J Cardiol. 1989;64(suppl):3F–9F
  15. Goldberg AD, Becker LC, Bonsall R, Cohen JD, Ketterer MW, Kaufman PG, et al. Ischemic, hemodynamic, and neurohormonal responses to mental and exercise stress: experience from the Psychophysiological Investigations of Myocardial Ischemia study (PIMI). Circulation. 1996;94:2402–2409
  16. Sherwood A, Johnson K, Blumenthal JA, Hinderliter AL. Endothelial function and hemodynamic responses during mental stress. Psychosom Med. 1999;61:365–370
  17. Peix A, Trapaga A, Asen L, Ponce F, Infante O, Valiente J, et al. Mental stress-induced myocardial ischemia in women with angina and normal coronary angiograms. J Nucl Cardiol. 2006;13:507–513
  18. Ghiadoni L, Donald AE, Cropley M, Mullen MJ, Oakley G, Taylor M, et al. Mental stress induces transient endothelial dysfunction in humans. Circulation. 2000;102:2473–2478
  19. Gottdiener JS, Kop WJ, Hausner E, McCeney MK, Herrington D, Krantz DS. Effects of mental stress on flow-mediated brachial arterial dilation and influence of behavioral factors and hypercholesterolemia in subjects without cardiovascular disease. Am J Cardiol. 2003;92:687–691
  20. Jambrik Z, Sebastiani L, Picano E, Ghelarducci B, Santarcangelo EL. Hypnotic modulation of flow-mediated endothelial response to mental stress. Int J Psychophysiol. 2005;55:221–227
  21. Spieker LE, Hurlimann D, Ruschitzka F, Corti R, Enseleit F, Shaw S, et al. Mental stress induces prolonged endothelial dysfunction via endothelin-A receptors. Circulation. 2002;105:2817–2820
  22. Jambrik Z, Santarcangelo EL, Rudisch T, Varga A, Forster T, Carli G. Modulation of pain-induced endothelial dysfunction by hypnotisability. Pain. 2005;116:181–186
  23. Lind L, Johansson K, Hall J. The effects of mental stress and the cold pressure test on flow-mediated vasodilation. Blood Press. 2002;11:22–27

 This study was supported by Grants HL59672 and M01-RR-30 from the National Institutes of Health, Bethesda, Maryland.

PII: S0002-9149(09)02212-7

doi: 10.1016/j.amjcard.2009.08.647

American Journal of Cardiology
Volume 105, Issue 1 , Pages 25-28 , 1 January 2010