American Journal of Cardiology
Volume 105, Issue 1 , Pages 1-9 , 1 January 2010

Comparison of Usefulness of Heart-Type Fatty Acid Binding Protein Versus Cardiac Troponin T for Diagnosis of Acute Myocardial Infarction

  • Georg Haltern, MD

      Affiliations

    • HELIOS Heart Center Wuppertal, University of Witten/Herdecke, Wuppertal, Germany
    • Corresponding Author InformationCorresponding author: Tel: (+49) 202-896-5796; fax: (+49) 202-896-5707
  • ,
  • Sigune Peiniger, MD

      Affiliations

    • HELIOS Heart Center Wuppertal, University of Witten/Herdecke, Wuppertal, Germany
  • ,
  • Alexander Bufe, MD

      Affiliations

    • HELIOS Heart Center Wuppertal, University of Witten/Herdecke, Wuppertal, Germany
  • ,
  • Gebhard Reiss, PhD

      Affiliations

    • University of Witten/Herdecke, Witten, Germany
  • ,
  • Hartmut Gülker, PhD

      Affiliations

    • HELIOS Heart Center Wuppertal, University of Witten/Herdecke, Wuppertal, Germany
  • ,
  • Thomas Scheffold, PhD

      Affiliations

    • Institute for Heart and Circulation Research, University of Witten/Herdecke, Dortmund, Germany

Received 5 May 2009 ,Revised 4 August 2009 ,Accepted 4 August 2009.

References 

  1. Christenson RH, Azzazy HME. Biomarkers of myocardial necrosis—past, present, and future. In:  Morrow DA editors. Cardiovascular Biomarkers: Pathophysiology and Disease Management. Totowa, NJ: Humana Press; 2006;p. 3–25
  2. Thygesen K, Alpert JS, White HD, Jaffe AS, Apple FS, Galvani M, et al. Universal definition of myocardial infarction. Circulation. 2007;116:2634–2653
  3. Panteghini M, Pagani F, Bonetti G. The sensitivity of cardiac markers: an evidence-based approach. Clin Chem Lab Med. 1999;37:1097–1106
  4. Salerno SM, Alguire PC, Waxman HS. Competency in interpretation of 12-lead electrocardiograms: a summary and appraisal of published evidence. Ann Intern Med. 2003;138:751–760
  5. Wagner GS, Macfarlane P, Wellens H, Josephson M, Gorgels A, Mirvis DM, et al. AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram. Part VI (Acute ischemia/infarction: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Endorsed by the International Society for Computerized Electrocardiology). J Am Coll Cardiol. 2009;53:1003–1011
  6. Alhadi HA, Fox KA. Do we need additional markers of myocyte necrosis: the potential value of heart fatty-acid-binding protein. QJM. 2004;97:187–198
  7. Ecollan P, Collet JP, Boon G, Tanguy ML, Fievet ML, Haas R, et al. Pre-hospital detection of acute myocardial infarction with ultra-rapid human fatty acid-binding protein (H-FABP) immunoassay. Int J Cardiol. 2007;119:349–354
  8. Liao J, Chan CP, Cheung YC, Lu JH, Luo Y, Cautherley GW, et al. Human heart-type fatty acid-binding protein for on-site diagnosis of early acute myocardial infarction. Int J Cardiol. 2008;133:420–423
  9. Mad P, Domanovits H, Fazelnia C, Stiassny K, Russmuller G, Cseh A, et al. Human heart-type fatty acid-binding protein as a point-of-care test in the early diagnosis of acute myocardial infarction. QJM. 2007;100:203–210
  10. McCann CJ, Glover BM, Menown IB, Moore MJ, McEneny J, Owens CG, et al. Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T. Eur Heart J. 2008;29:2843–2850
  11. Ruzgar O, Bilge AK, Bugra Z, Umman S, Yilmaz E, Ozben B, et al. The use of human heart-type fatty acid-binding protein as an early diagnostic biochemical marker of myocardial necrosis in patients with acute coronary syndrome, and its comparison with troponin-T and creatine kinase-myocardial band. Heart Vessels. 2006;21:309–314
  12. Valle HA, Riesgo LG, Bel MS, Gonzalo FE, Sanchez MS, Oliva LI. Clinical assessment of heart-type fatty acid binding protein in early diagnosis of acute coronary syndrome. Eur J Emerg Med. 2008;15:140–144
  13. Goldman L, Cook EF, Johnson PA, Brand DA, Rouan GW, Lee TH. Prediction of the need for intensive care in patients who come to the emergency departments with acute chest pain. N Engl J Med. 1996;334:1498–1504
  14. Limkakeng A, Gibler WB, Pollack C, Hoekstra JW, Sites F, Shofer FS, et al. Combination of Goldman risk and initial cardiac troponin I for emergency department chest pain patient risk stratification. Acad Emerg Med. 2001;8:696–702
  15. Gorski J, Hermens WT, Borawski J, Mysliwiec M, Glatz JF. Increased fatty acid-binding protein concentration in plasma of patients with chronic renal failure. Clin Chem. 1997;43:193–195
  16. Nayashida N, Chihara S, Tayama E, Akasu K, Kai E, Kawara T, et al. Influence of renal function on serum and urinary heart fatty acid-binding protein levels. J Cardiovasc Surg. 2001;42:735–740
  17. Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infarction redefined—a consensus document of the joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 2000;36:959–969
  18. Tucker JF, Collins RA, Anderson AJ, Hauser J, Kalas J, Apple FS. Early diagnostic efficiency of cardiac troponin I and troponin T for acute myocardial infarction. Acad Emerg Med. 1997;4:13–21
  19. Balk EM, Ioannidis JP, Salem D, Chew PW, Lau J. Accuracy of biomarkers to diagnose acute cardiac ischemia in the emergency department: a meta-analysis. Ann Emerg Med. 2001;37:478–494
  20. Nakata T, Hashimoto A, Hase M, Tsuchihashi K, Shimamoto K. Human heart-type fatty acid-binding protein as an early diagnostic and prognostic marker in acute coronary syndrome. Cardiology. 2003;99:96–104
  21. Seino Y, Ogata K, Takano T, Ishii J, Hishida H, Morita H, et al. Use of a whole blood rapid panel test for heart-type fatty acid-binding protein in patients with acute chest pain: comparison with rapid troponin T and myoglobin tests. Am J Med. 2003;115:185–190
  22. Arimoto T, Takeishi Y, Shiga R, Fukui A, Tachibana H, Nozaki N, et al. Prognostic value of elevated circulating heart-type fatty acid binding protein in patients with congestive heart failure. J Card Fail. 2005;11:56–60
  23. Iida M, Yamazaki M, Honjo H, Kodama I, Kamiya K. Predictive value of heart-type fatty acid-binding protein for left ventricular remodelling and clinical outcome of hypertensive patients with mild-to-moderate aortic valve diseases. J Hum Hypertens. 2007;21:551–557
  24. Pelsers MM, Hermens WT, Glatz JF. Fatty acid-binding proteins as plasma markers of tissue injury. Clin Chim Acta. 2005;352:15–35
  25. Chan CP, Sanderson JE, Glatz JF, Cheng WS, Hempel A, Renneberg R. A superior early myocardial infarction marker: human heart-type fatty acid-binding protein. Z Kardiol. 2004;93:388–397

PII: S0002-9149(09)02210-3

doi: 10.1016/j.amjcard.2009.08.645

American Journal of Cardiology
Volume 105, Issue 1 , Pages 1-9 , 1 January 2010