American Journal of Cardiology
Volume 104, Issue 12 , Pages 1743-1747 , 15 December 2009

Comparison of Factors Associated With Coronary Artery Dilation Only Versus Coronary Artery Aneurysms in Patients With Kawasaki Disease

Presented at the IX International Kawasaki Disease Symposium (Taipei, Taiwan) 2008, April 10–12.

  • Tarun Sabharwal, BSc

      Affiliations

    • Labatt Family Heart Centre, Division of Cardiology, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada
  • ,
  • Cedric Manlhiot, BSc

      Affiliations

    • Labatt Family Heart Centre, Division of Cardiology, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada
  • ,
  • Susanne M. Benseler, MD, MSc

      Affiliations

    • Division of Rheumatology, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada
  • ,
  • Pascal N. Tyrrell, MSc

      Affiliations

    • Division of Rheumatology, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada
  • ,
  • Nita Chahal, CNS-NP

      Affiliations

    • Labatt Family Heart Centre, Division of Cardiology, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada
  • ,
  • Rae S.M. Yeung, MD, PhD

      Affiliations

    • Division of Rheumatology, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada
  • ,
  • Brian W. McCrindle, MD, MPH

      Affiliations

    • Labatt Family Heart Centre, Division of Cardiology, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada
    • Corresponding Author InformationCorresponding author: Tel: (416) 813-7610; fax: (416) 813-7547

Received 15 May 2009 ,Revised 29 July 2009 ,Accepted 29 July 2009.

References 

  1. Fukushige J, Takahashi N, Ueda K, Hijii T, Igarashi H, Ohshima A. Long-term outcome of coronary abnormalities in patients after Kawasaki disease. Pediatr Cardiol. 1996;17:71–76
  2. Levy DM, Silverman ED, Massicotte MP, McCrindle BW, Yeung RS. Longterm outcomes in patients with giant aneurysms secondary to Kawasaki disease. J Rheumatol. 2005;32:928–934
  3. Suzuki A, Kamiya T, Arakaki Y, Kinoshita Y, Kimura K. Fate of coronary arterial aneurysms in Kawasaki disease. Am J Cardiol. 1994;74:822–824
  4. Kuramochi Y, Ohkubo T, Takechi N, Fukumi D, Uchikoba Y, Ogawa S. Hemodynamic factors of thrombus formation in coronary aneurysms associated with Kawasaki disease. Pediatr Int. 2000;42:470–475
  5. McCrindle BW. Cardiovascular complications—coronary artery structure and function. Prog Pediatr Cardiol. 2004;19:147–152
  6. Beiser AS, Takahashi M, Baker AL, Sundel RP, Newburger JW US Multicenter Kawasaki Disease Study Group. A predictive instrument for coronary artery aneurysms in Kawasaki disease. Am J Cardiol. 1998;81:1116–1120
  7. Kim T, Choi W, Woo CW, Choi B, Lee J, Lee K, et al. Predictive risk factors for coronary artery abnormalities in Kawasaki disease. Eur J Pediatr. 2007;166:421–425
  8. McCrindle BW, Li JS, Minich LL, Colan SD, Atz AM, Takahashi M, et al. Coronary artery involvement in children with Kawasaki disease: risk factors from analysis of serial normalized measurements. Circulation. 2007;116:174–179
  9. Belay ED, Maddox RA, Holman RC, Curns AT, Ballah K, Schonberger LB. Kawasaki syndrome and risk factors for coronary artery abnormalities: United States, 1994–2003. Pediatr Infect Dis J. 2006;25:245–249
  10. Honkanen VE, McCrindle BW, Laxer RM, Feldman BM, Schneider R, Silverman ED. Clinical relevance of the risk factors for coronary artery inflammation in Kawasaki disease. Pediatr Cardiol. 2003;24:122–126
  11. Morikawa Y, Ohashi Y, Harada K, Asai T, Okawa S, Nagashima M, et al. Coronary risks after high-dose gamma-globulin in children with Kawasaki disease. Pediatr Int. 2000;42:464–469
  12. Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation. 2004;110:2747–2771
  13. de Zorzi A, Colan SD, Gauvreau K, Baker AL, Sundel RP, Newburger JW. Coronary artery dimensions may be misclassified as normal in Kawasaki disease. J Pediatr. 1998;133:254–258
  14. Research Committee on Kawasaki Disease. JMHC Report: Report of Subcommittee on Standardization of Diagnostic Criteria and Reporting of Coronary Artery Lesions in Kawasaki Disease. Tokyo, Japan: Ministry of Health and Welfare; 1984;
  15. Harada K. Intravenous gamma-globulin treatment in Kawasaki disease. Acta Paediatr Jpn. 1991;33:805–810
  16. Iemura M, Ishii M, Sugimura T, Akagi T, Kato H. Long term consequences of regressed coronary aneurysms after Kawasaki disease: vascular wall morphology and function. Heart. 2000;83:307–311
  17. McCrindle BW, McIntyre S, Kim C, Lin T, Adeli K. Are patients after Kawasaki disease at increased risk for accelerated atherosclerosis?. J Pediatr. 2007;151:244–248248 e1
  18. Silva AA, Maeno Y, Hashmi A, Smallhorn JF, Silverman ED, McCrindle BW. Cardiovascular risk factors after Kawasaki disease: a case-control study. J Pediatr. 2001;138:400–405
  19. Suzuki A, Miyagawa-Tomita S, Nakazawa M, Yutani C. Remodeling of coronary artery lesions due to Kawasaki disease: comparison of arteriographic and immunohistochemical findings. Jpn Heart J. 2000;41:245–256
  20. Tsuda E, Kamiya T, Kimura K, Ono Y, Echigo S. Coronary artery dilatation exceeding 4.0 mm during acute Kawasaki disease predicts a high probability of subsequent late intima-medial thickening. Pediatr Cardiol. 2002;23:9–14
  21. Terai M, Shulman ST. Prevalence of coronary artery abnormalities in Kawasaki disease is highly dependent on gamma globulin dose but independent of salicylate dose. J Pediatr. 1997;131:888–893
  22. Nakamura Y, Yashiro M, Uehara R, Watanabe M, Tajimi M, Oki I, et al. Case-control study of giant coronary aneurysms due to Kawasaki disease. Pediatr Int. 2003;45:410–413
  23. Manlhiot C, Yeung RS, Clarizia NA, Chahal N, McCrindle BW. Kawasaki disease at the extremes of the age spectrum. Pediatrics. 2009;124:e410–e415
  24. Dajani AS, Taubert KA, Gerber MA, Shulman ST, Ferrieri P, Freed M, et al Diagnosis and therapy of Kawasaki disease in children. Circulation. 1993;87:1776–1780
  25. Lee KY, Han JW, Hong JH, Lee HS, Lee JS, Whang KT. Inflammatory processes in Kawasaki disease reach their peak at the sixth day of fever onset: laboratory profiles according to duration of fever. J Korean Med Sci. 2004;19:501–504
  26. Burns JC, Capparelli EV, Brown JA, Newburger JW, Glode MP US/Canadian Kawasaki Syndrome Study Group. Intravenous gamma-globulin treatment and retreatment in Kawasaki disease. Pediatr Infect Dis J. 1998;17:1144–1148
  27. Minich LL, Sleeper LA, Atz AM, McCrindle BW, Lu M, Colan SD, et al. Delayed diagnosis of Kawasaki disease: what are the risk factors?. Pediatrics. 2007;120:e1434–e1440

 Supported in part by the Canadian Imperial Bank of Commerce (CIBC) World Markets Children's Miracle Foundation (Toronto, Ontario, Canada).

PII: S0002-9149(09)01497-0

doi: 10.1016/j.amjcard.2009.07.062

American Journal of Cardiology
Volume 104, Issue 12 , Pages 1743-1747 , 15 December 2009