American Journal of Cardiology
Volume 104, Issue 11 , Pages 1465-1471 , 1 December 2009

Usefulness of Pregnancy-Associated Plasma Protein A in Patients With Acute Coronary Syndrome

  • Kasper K. Iversen, MD

      Affiliations

    • Department of Cardiology, Hillerod Hospital, Hillerod, Denmark
    • Corresponding Author InformationCorresponding author: Tel: (+45) 4829-7345; fax: (+45) 4829-4329
    • ,
  • Morten Dalsgaard, MD

      Affiliations

    • Department of Cardiology, Hillerod Hospital, Hillerod, Denmark
    • ,
  • Ane S. Teisner, MD

      Affiliations

    • Department of Internal Medicine, Copenhagen University Hospital, Bispebjerg Hospital, Copenhagen, Denmark
    • ,
  • Mikkel Schoos, MD

      Affiliations

    • Department of Cardiology, Hillerod Hospital, Hillerod, Denmark
    • ,
  • Borge Teisner, MD

      Affiliations

    • Department of Immunology and Microbiology, University of Southern Denmark, Odense, Denmark
    • ,
  • Henrik Nielsen, MD, DMSc

      Affiliations

    • Department of Cardiology, Copenhagen University Hospital, Bispebjerg Hospital, Copenhagen, Denmark
    • ,
  • Peter Clemmensen, MD, DMSc

      Affiliations

    • The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    • ,
  • Peer Grande, MD, DMSc

      Affiliations

    • The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

Received 12 May 2009 ,Revised 2 July 2009 ,Accepted 2 July 2009.

References 

  1. Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE, et al. ACC/AHA guidelines for the management of patients with unstable angina/non–ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients with Unstable Angina/Non–ST-Elevation myocardial infarction) developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol. 2007;50:e1–e157
  2. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part II. Circulation. 2003;108:1772–1778
  3. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I. Circulation. 2003;108:1664–1672
  4. Bayes-Genis A, Conover CA, Overgaard MT, Bailey KR, Christiansen M, Holmes DR, et al. Pregnancy-associated plasma protein A as a marker of acute coronary syndromes. N Engl J Med. 2001;345:1022–1029
  5. Bassand JP, Hamm CW, Ardissino D, Boersma E, Budaj A, Fernandez-Aviles F, et al. Guidelines for the diagnosis and treatment of non–ST-segment elevation acute coronary syndromes: the Task Force for the Diagnosis and Treatment of Non–ST-Segment Elevation Acute Coronary Syndromes of the European Society of Cardiology. Eur Heart J. 2007;28:1598–1660
  6. Iversen KK, Teisner AS, Teisner B, Kliem A, Thanning P, Nielsen H, et al. Pregnancy associated plasma protein A, a potential marker for vulnerable plaque in patients with non–ST-segment elevation acute coronary syndrome. Clin Biochem. 2009;42:828–834
  7. Andersen HR, Nielsen TT, Rasmussen K, Thuesen L, Kelbaek H, Thayssen P, et al. A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. N Engl J Med. 2003;349:733–742
  8. Westergaard JG. Studies on Pregnancy Associated Plasma Protein-A (PAPP-A) in Normal and Abnormal Pregnancy (DMSc Thesis). Odense, Denmark: Odense University; 1987;
  9. Rossen M, Iversen K, Teisner A, Teisner B, Kliem A, Grudzinskas G. Optimisation of sandwich ELISA based on monoclonal antibodies for the specific measurement of pregnancy-associated plasma protein (PAPP-A) in acute coronary syndrome. Clin Biochem. 2007;40:478–484
  10. Burke AP, Farb A, Malcom GT, Liang YH, Smialek J, Virmani R. Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N Engl J Med. 1997;336:1276–1282
  11. Goldstein JA, Demetriou D, Grines CL, Pica M, Shoukfeh M, O'Neill WW. Multiple complex coronary plaques in patients with acute myocardial infarction. N Engl J Med. 2000;343:915–922
  12. Mann J, Davies MJ. Mechanisms of progression in native coronary artery disease: role of healed plaque disruption. Heart. 1999;82:265–268
  13. Nissen SE. Who is at risk for atherosclerotic disease? (Lessons from intravascular ultrasound). Am J Med. 2002;112(Suppl 8A):27S–33S
  14. Rioufol G, Finet G, Ginon I, Andre-Fouet X, Rossi R, Vialle E, et al. Multiple atherosclerotic plaque rupture in acute coronary syndrome: a three-vessel intravascular ultrasound study. Circulation. 2002;106:804–808
  15. Brugger-Andersen T, Hetland O, Ponitz V, Grundt H, Nilsen DW. The effect of primary percutaneous coronary intervention as compared to tenecteplase on myeloperoxidase, pregnancy-associated plasma protein A, soluble fibrin and D-dimer in acute myocardial infarction. Thromb Res. 2007;119:415–421
  16. Consuegra-Sanchez L, Fredericks S, Kaski JC. Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular risk. Atherosclerosis. 2009;203:346–352
  17. Iversen KK, Teisner AS, Teisner B, Kliem A, Thanning P, Grande P, et al. Pregnancy associated plasma protein A, a novel, quick, and sensitive marker in ST-elevation myocardial infarction. Am J Cardiol. 2008;101:1389–1394
  18. Khosravi J, Diamandi A, Krishna RG, Bodani U, Mistry J, Khaja N. Pregnancy associated plasma protein-A: ultrasensitive immunoassay and determination in coronary heart disease. Clin Biochem. 2002;35:531–538
  19. Qin QP, Laitinen P, Majamaa-Voltti K, Eriksson S, Kumpula EK, Pettersson K. Release patterns of pregnancy associated plasma protein A (PAPP-A) in patients with acute coronary syndromes. Scand Cardiovasc J. 2002;36:358–361
  20. Schoos M, Iversen K, Teisner A, Teisner B, Thaning P, Kliem A, et al. Release patterns of pregnancy-associated plasma protein A in patients with acute coronary syndromes assessed by an optimized monoclonal antibody assay. Scand J Clin Lab Invest. 2009;69:121–127
  21. Lund J, Qin QP, Ilva T, Nikus K, Eskola M, Porela P, et al. Pregnancy-associated plasma protein A: a biomarker in acute ST-elevation myocardial infarction (STEMI). Ann Med. 2006;38:221–228
  22. Heeschen C, Dimmeler S, Hamm CW, Fichtlscherer S, Simoons ML, Zeiher AM. Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis. J Am Coll Cardiol. 2005;45:229–237
  23. Laterza OF, Cameron SJ, Chappell D, Sokoll LJ, Green GB. Evaluation of pregnancy-associated plasma protein A as a prognostic indicator in acute coronary syndrome patients. Clin Chim Acta. 2004;348:163–169
  24. Lund J, Qin QP, Ilva T, Pettersson K, Voipio-Pulkki LM, Porela P, et al. Circulating pregnancy-associated plasma protein A predicts outcome in patients with acute coronary syndrome but no troponin I elevation. Circulation. 2003;108:1924–1926

PII: S0002-9149(09)01354-X

doi: 10.1016/j.amjcard.2009.07.017

American Journal of Cardiology
Volume 104, Issue 11 , Pages 1465-1471 , 1 December 2009

Article Tools

* Image Usage & Resolution