American Journal of Cardiology
Volume 104, Issue 10 , Pages 1324-1329 , 15 November 2009

Relation of Patient Age and Mortality to Reported Contraindications to Early Beta-Blocker Use for Non–ST-Elevation Acute Coronary Syndrome

  • Nancy M. Allen LaPointe, PharmD

      Affiliations

    • Duke Clinical Research Institute, Durham, North Carolina
    • Corresponding Author InformationCorresponding author: Tel: (919) 668-8529; fax: (919) 668-7166
    • ,
  • Anita Y. Chen, MS

      Affiliations

    • Duke Clinical Research Institute, Durham, North Carolina
    • ,
  • Matthew T. Roe, MD, MHS

      Affiliations

    • Duke Clinical Research Institute, Durham, North Carolina
    • ,
  • David J. Cohen, MD, MSc

      Affiliations

    • Saint-Luke's Mid America Heart Institute and University of Missouri–Kansas City, Kansas City, Missouri
    • ,
  • Deborah B. Diercks, MD, MSc

      Affiliations

    • University of California, Davis, Medical Center, Sacramento, California
    • ,
  • James W. Hoekstra, MD

      Affiliations

    • Wake Forest University Health Sciences, Winston-Salem, North Carolina
    • ,
  • Francis M. Fesmire, MD

      Affiliations

    • Erlanger Health System, Chattanooga, Tennessee
    • ,
  • W. Brian Gibler, MD

      Affiliations

    • University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • E. Magnus Ohman, MD

      Affiliations

    • Duke Clinical Research Institute, Durham, North Carolina
    • ,
  • Eric D. Peterson, MD, MPH

      Affiliations

    • Duke Clinical Research Institute, Durham, North Carolina

Received 15 May 2009 ,Revised 28 June 2009 ,Accepted 28 June 2009.

References 

  1. Hoekstra JW, Pollack CV, Roe MT, Peterson ED, Brindis R, Harrington RA, et al. Improving the care of patients with non–ST-elevation acute coronary syndromes in the emergency department: the CRUSADE initiative. Acad Emerg Med. 2002;9:1146–1155
  2. Liang K, Zeger S. Longitudinal data analysis using generalized linear models. Biometrika. 1986;73:13–22
  3. Eagle KA, Lim MJ, Dabbous OH, Pieper KS, Goldberg RJ, Van de Werf F, et al. A validated prediction model for all forms of acute coronary syndrome: estimating the risk of 6-month postdischarge death in an international registry. JAMA. 2004;291:2727–2733
  4. Norwegian Multicenter Study Group. Timolol-induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction. N Engl J Med. 1981;304:801–807
  5. Hjalmarson A, Elmfeldt D, Herlitz J, Holmberg S, Málek I, Nyberg G, et al. Effect on mortality of metoprolol in acute myocardial infarction: a double-blind randomised trial. Lancet. 1981;2:823–827
  6. Beta-blocker Heart Attack Trial Research Group. A randomized trial of propranolol in patients with acute myocardial infarction (I. Mortality results). JAMA. 1982;247:1707–1714
  7. MIAMI Trial Research Group. Metoprolol in acute myocardial infarction (MIAMI): a randomised placebo-controlled international trial. Eur Heart J. 1985;6:199–211
  8. TIMI Study Group. Comparison of invasive and conservative strategies after treatment with intravenous tissue plasminogen activator in acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) phase II trial. N Engl J Med. 1989;320:618–627
  9. Roberts R, Rogers WJ, Mueller HS, Lambrew CT, Diver DJ, Smith HC, et al. Immediate versus deferred beta-blockade following thrombolytic therapy in patients with acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) II-B study. Circulation. 1991;83:422–437
  10. Gheorghiade M, Goldstein S. Beta-blockers in the post-myocardial infarction patient. Circulation. 2002;106:394–398
  11. Gottlieb SS, McCarter RJ, Vogel RA. Effect of beta-blockade on mortality among high-risk and low-risk patients after myocardial infarction. N Engl J Med. 1998;339:489–497
  12. Goldberg RJ, Spencer FA, Steg PG, Flather M, Montalescot G, Gurfinkel EP, et al. Increasing use of single and combination medical therapy in patients hospitalized for acute myocardial infarction in the 21st century: a multinational perspective. Arch Intern Med. 2007;167:1766–1773
  13. Krumholz HM, Radford MJ, Wang Y, Chen J, Marciniak TA. Early beta-blocker therapy for acute myocardial infarction in elderly patients. Ann Intern Med. 1999;131:648–654
  14. Antman EM, Anbe DT, Armstrong PW, Bates ER, Green LA, Hand M, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the ACC/AHA Task Force on Practice guidelines. J Am Coll Cardiol. 2004;44:e1–e211
  15. Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE, et al. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non–ST-elevation myocardial infarction: a report of the ACC/AHA Task Force on Practice guidelines. J Am Coll Cardiol. 2007;50:e1–e157
  16. Krumholz HM, Anderson JL, Bachelder BL, Fesmire FM, Fihn SD, Foody JM, et al. ACC/AHA 2008 performance measures for adults with ST-elevation and non–ST-elevation myocardial infarction: a report of the ACC/AHA Task Force on Performance Measures. J Am Coll Cardiol. 2008;52:2046–2099
  17. Chen ZM, Pan HC, Chen YP, Peto R, Collins R, Jiang LX, et al. Early intravenous then oral metoprolol in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet. 2005;366:1622–1632
  18. Setoguchi S, Glynn RJ, Avorn J, Levin R, Winkelmayer WC. Ten-year trends of cardiovascular drug use after myocardial infarction among community-dwelling persons > or = 65 years of age. Am J Cardiol. 2007;100:1061–1067
  19. Vega DD, Dolan KL, Pollack ML. Beta-blocker use in elderly ED patients with acute myocardial infarction. Am J Emerg Med. 2006;24:435–439
  20. Alexander KP, Newby LK, Armstrong PW, Cannon CP, Gibler WB, Rich MW, et al. Acute coronary care in the elderly, part II: ST-segment-elevation myocardial infarction: a scientific statement for healthcare professionals from the AHA Council on Clinical Cardiology: in collaboration with the Society of Geriatric Cardiology. Circulation. 2007;115:2570–2589
  21. Skolnick AH, Alexander KP, Chen AY, Roe MT, Pollack CV, Ohman EM, et al. Characteristics, management, and outcomes of 5,557 patients age > or = 90 years with acute coronary syndromes: results from the CRUSADE initiative. J Am Coll Cardiol. 2007;49:1790–1797

PII: S0002-9149(09)01316-2

doi: 10.1016/j.amjcard.2009.06.054

American Journal of Cardiology
Volume 104, Issue 10 , Pages 1324-1329 , 15 November 2009

Article Tools

* Image Usage & Resolution