American Journal of Cardiology
Volume 104, Issue 9 , Pages 1189-1193 , 1 November 2009

Prevalence of Unresponsiveness to Aspirin and/or Clopidogrel in Patients With Stable Coronary Heart Disease

  • Marie Lordkipanidzé, MSc

      Affiliations

    • Faculty of Pharmacy, Université de Montréal, Montréal, Québec, Canada
    • Research Center, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
    • Department of Pharmacy, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
    • ,
  • Jean G. Diodati, MD

      Affiliations

    • Research Center, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
    • Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada
    • Division of Cardiology, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
    • ,
  • Erick Schampaert, MD

      Affiliations

    • Research Center, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
    • Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada
    • Division of Cardiology, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
    • ,
  • Donald A. Palisaitis, MD

      Affiliations

    • Research Center, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
    • Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada
    • Division of Cardiology, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
    • ,
  • Chantal Pharand, PharmD

      Affiliations

    • Faculty of Pharmacy, Université de Montréal, Montréal, Québec, Canada
    • Research Center, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
    • Department of Pharmacy, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
    • Corresponding Author InformationCorresponding author: Tel: (514) 338-2222, ext. 2506; fax: (514) 338-2694

Received 17 April 2009 ,Revised 5 June 2009 ,Accepted 5 June 2009.

References 

  1. Lordkipanidzé M, Pharand C, Palisaitis DA, Diodati JG. Aspirin resistance: truth or dare. Pharmacol Ther. 2006;112:733–743
  2. Nguyen TA, Diodati JG, Pharand C. Resistance to clopidogrel: a review of the evidence. J Am Coll Cardiol. 2005;45:1157–1164
  3. Michelson AD. Platelet function testing in cardiovascular diseases. Circulation. 2004;110:e489–e493
  4. Cuisset T, Frere C, Quilici J, Barbou F, Morange PE, Hovasse T, et al. High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome. J Thromb Haemost. 2006;4:542–549
  5. Cuisset T, Frere C, Quilici J, Morange PE, Camoin L, Bali L, et al. Relationship between aspirin and clopidogrel responses in acute coronary syndrome and clinical predictors of non response. Thromb Res. 2009;123:597–603
  6. Lev EI, Patel RT, Maresh KJ, Guthikonda S, Granada J, DeLao T, et al. Aspirin and clopidogrel drug response in patients undergoing percutaneous coronary intervention: the role of dual drug resistance. J Am Coll Cardiol. 2006;47:27–33
  7. Gori AM, Marcucci R, Migliorini A, Valenti R, Moschi G, Paniccia R, et al. Incidence and clinical impact of dual nonresponsiveness to aspirin and clopidogrel in patients with drug-eluting stents. J Am Coll Cardiol. 2008;52:734–739
  8. Buch AN, Singh S, Roy P, Javaid A, Smith KA, George CE, et al. Measuring aspirin resistance, clopidogrel responsiveness, and postprocedural markers of myonecrosis in patients undergoing percutaneous coronary intervention. Am J Cardiol. 2007;99:1518–1522
  9. Cuisset T, Hamilos M, Sarma J, Sarno G, Wyffels E, Vanderheyden M, et al. Relation of low response to clopidogrel assessed with point-of-care assay to periprocedural myonecrosis in patients undergoing elective coronary stenting for stable angina pectoris. Am J Cardiol. 2008;101:1700–1703
  10. Fontana P, Nolli S, Reber G, de Moerloose P. Biological effects of aspirin and clopidogrel in a randomized cross-over study in 96 healthy volunteers. J Thromb Haemost. 2006;4:813–819
  11. Linden MD, Furman MI, Frelinger AL, Fox ML, Barnard MR, Li Y, et al. Indices of platelet activation and the stability of coronary artery disease. J Thromb Haemost. 2007;5:761–765
  12. Borna C, Lazarowski E, van Heusden C, Ohlin H, Erlinge D. Resistance to aspirin is increased by ST-elevation myocardial infarction and correlates with adenosine diphosphate levels. Thromb J. 2005;3:10
  13. Hobikoglu GF, Norgaz T, Aksu H, Ozer O, Erturk M, Nurkalem Z, et al. High frequency of aspirin resistance in patients with acute coronary syndrome. Tohoku J Exp Med. 2005;207:59–64
  14. Serebruany VL, Cummings CC, Malinin AI, Steinhubl SR, Gurbel PA. Uniform platelet activation exists before coronary stent implantation despite aspirin therapy. Am Heart J. 2001;142:611–616
  15. Soffer D, Moussa I, Harjai KJ, Boura JA, Dixon SR, Grines CL, et al. Impact of angina class on inhibition of platelet aggregation following clopidogrel loading in patients undergoing coronary intervention: do we need more aggressive dosing regimens in unstable angina?. Catheter Cardiovasc Interv. 2003;59:21–25
  16. Guthikonda S, Lev EI, Patel R, Delao T, Bergeron AL, Dong JF, et al. Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin. J Thromb Haemost. 2007;5:490–496
  17. Lordkipanidzé M, Diodati JG, Turgeon J, Schampaert E, Palisaitis DA, Pharand C. Platelet count, not oxidative stress, may contribute to inadequate platelet inhibition by aspirin. Int J Cardiol. 2009;doi:10.1016/j.ijcard.2009.1001.1037
  18. Cipollone F, Ciabattoni G, Patrignani P, Pasquale M, Di Gregorio D, Bucciarelli T, et al. Oxidant stress and aspirin-insensitive thromboxane biosynthesis in severe unstable angina. Circulation. 2000;102:1007–1013
  19. Loscalzo J. Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ Res. 2001;88:756–762
  20. Santos MT, Valles J, Lago A, Tembl J, Sanchez E, Moscardo A, et al. Residual platelet thromboxane A2 and prothrombotic effects of erythrocytes are important determinants of aspirin resistance in patients with vascular disease. J Thromb Haemost. 2008;6:615–621
  21. Taubert D, von Beckerath N, Grimberg G, Lazar A, Jung N, Goeser T, et al. Impact of P-glycoprotein on clopidogrel absorption. Clin Pharmacol Ther. 2006;80:486–501
  22. Mega JL, Close SL, Wiviott SD, Shen L, Hockett RD, Brandt JT, et al. Cytochrome p-450 polymorphisms and response to clopidogrel. N Engl J Med. 2009;360:354–362
  23. Simon T, Verstuyft C, Mary-Krause M, Quteineh L, Drouet E, Meneveau N, et al. Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med. 2009;360:363–375
  24. Suh JW, Koo BK, Zhang SY, Park KW, Cho JY, Jang IJ, et al. Increased risk of atherothrombotic events associated with cytochrome P450 3A5 polymorphism in patients taking clopidogrel. Can Med Assoc J. 2006;174:1715–1722
  25. Ho PM, Maddox TM, Wang L, Fihn SD, Jesse RL, Peterson ED, et al. Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome. JAMA. 2009;301:937–944
  26. Snoep JD, Hovens MM, Eikenboom JC, van der Bom JG, Huisman MV. Association of laboratory-defined aspirin resistance with a higher risk of recurrent cardiovascular events: a systematic review and meta-analysis. Arch Intern Med. 2007;167:1593–1599
  27. Snoep JD, Hovens MM, Eikenboom JC, van der Bom JG, Jukema JW, Huisman MV. Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: a systematic review and meta-analysis. Am Heart J. 2007;154:221–231
  28. Lordkipanidzé M, Pharand C, Nguyen TA, Schampaert E, Palisaitis DA, Diodati JG. Comparison of four tests to assess inhibition of platelet function by clopidogrel in stable coronary artery disease patients. Eur Heart J. 2008;29:2877–2885
  29. Lordkipanidzé M, Pharand C, Schampaert E, Turgeon J, Palisaitis DA, Diodati JG. A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease. Eur Heart J. 2007;28:1702–1708

PII: S0002-9149(09)01251-X

doi: 10.1016/j.amjcard.2009.06.025

American Journal of Cardiology
Volume 104, Issue 9 , Pages 1189-1193 , 1 November 2009

Article Tools

* Image Usage & Resolution