American Journal of Cardiology
Volume 104, Issue 8 , Pages 1055-1062 , 15 October 2009

Impact of an Initial Strategy of Medical Therapy Without Percutaneous Coronary Intervention in High-Risk Patients From the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) Trial

  • David J. Maron, MD

      Affiliations

    • Vanderbilt University School of Medicine, Nashville, Tennessee
    • Corresponding Author InformationCorresponding author: Tel: (615) 400-8666; fax: (615) 936-8208
    • ,
  • John A. Spertus, MD, MPH

      Affiliations

    • Mid America Heart Institute, University of Missouri-Kansas City, Kansas City, Missouri
    • ,
  • G.B. John Mancini, MD

      Affiliations

    • University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Pamela M. Hartigan, PhD

      Affiliations

    • Veterans Affairs Cooperative Studies Program Coordinating Center, West Haven, Connecticut
    • ,
  • Steven P. Sedlis, MD

      Affiliations

    • New York Veterans Affairs Medical Center, New York, New York
    • ,
  • Eric R. Bates, MD

      Affiliations

    • University of Michigan Medical Center, Ann Arbor, Michigan
    • ,
  • William J. Kostuk, MD

      Affiliations

    • London Health Sciences Centre, London, Ontario, Canada
    • ,
  • Marcin Dada, MD

      Affiliations

    • Hartford Hospital, Hartford, Connecticut
    • ,
  • Daniel S. Berman, MD

      Affiliations

    • Cedars-Sinai Medical Center, Los Angeles, California
    • ,
  • Leslee J. Shaw, PhD

      Affiliations

    • Emory University, Atlanta, Georgia
    • ,
  • Bernard R. Chaitman, MD

      Affiliations

    • St. Louis University, St. Louis, Missouri
    • ,
  • Koon K. Teo, MB, BCh, PhD

      Affiliations

    • McMaster University Medical Center, Hamilton, Ontario, Canada
    • ,
  • Robert A. O'Rourke, MD

      Affiliations

    • South Texas Veterans Health Care System–Audie Murphy Campus, San Antonio, Texas
    • ,
  • William S. Weintraub, MD

      Affiliations

    • Christiana Care Health System, Newark, Delaware
    • ,
  • William E. Boden, MD

      Affiliations

    • Western New York Veterans Affairs Healthcare Network and Department of Medicine, Buffalo General Hospital-State University of New York, Buffalo, New York
    • ,
  • COURAGE Trial Research Group

Received 11 April 2008 ,Revised 20 May 2008 ,Accepted 20 May 2008.

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 This work was supported by the Cooperative Studies Program of the United States Department of Veterans Affairs Office of Research and Development [Veterans Affairs Cooperative Studies Program no. 424]; in collaboration with the Canadian Institutes of Health Research; and by unrestricted research grants from Merck (Whitehouse Station, New Jersey), Pfizer (New York, New York), Bristol-Myers-Squibb (New York, New York), Fujisawa (Tokyo, Japan), Kos Pharmaceuticals (Abbott Park, Illinois), Datascope (Fairfield, New Jersey), AstraZeneca (London, United Kingdom), Key Pharmaceutical (Sydney, Australia), Sanofi-Aventis (Paris, France), First Horizon (Alpharetta, Georgia), and GE Healthcare (Waukesha, Wisconsin). All industrial funding in support of the trial was directed through the United States Department of Veterans Affairs.

PII: S0002-9149(09)01179-5

doi: 10.1016/j.amjcard.2009.05.056

American Journal of Cardiology
Volume 104, Issue 8 , Pages 1055-1062 , 15 October 2009

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