American Journal of Cardiology
Volume 104, Issue 7 , Pages 932-935 , 1 October 2009

Relation of Alcohol Consumption and Coronary Heart Disease in Hypertensive Male Physicians (from the Physicians' Health Study)

  • Kathryn A. Britton, MD

      Affiliations

    • Harvard Medical School, Boston, Massachusetts
    • Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC), Boston Veterans Affairs Healthcare System, Boston, Massachusetts
    • Corresponding Author InformationCorresponding author: Tel: 857-364-6119; fax: 857-364-4424
    • ,
  • John Michael Gaziano, MD, MPH

      Affiliations

    • Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts
    • Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts
    • Harvard Medical School, Boston, Massachusetts
    • Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC), Boston Veterans Affairs Healthcare System, Boston, Massachusetts
    • Geriatric Research, Education, and Clinical Center (GRECC), Boston Veterans Affairs Healthcare System, Boston, Massachusetts
    • ,
  • Howard D. Sesso, ScD, MPH

      Affiliations

    • Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts
    • Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts
    • Harvard Medical School, Boston, Massachusetts
    • ,
  • Luc Djoussé, MD, DSc, MPH

      Affiliations

    • Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts
    • Harvard Medical School, Boston, Massachusetts
    • Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC), Boston Veterans Affairs Healthcare System, Boston, Massachusetts
    • Geriatric Research, Education, and Clinical Center (GRECC), Boston Veterans Affairs Healthcare System, Boston, Massachusetts

Received 11 February 2009 ,Revised 10 May 2009 ,Accepted 10 May 2009.

References 

  1. Beulens JWJ, Rimm EB, Ascherio A, Spiegelman D, Hendriks HFJ, Mukamal KJ. Alcohol consumption and risk for risk for coronary heart disease among men with hypertension. Ann Intern Med. 2007;146:10–19
  2. Malinski MK, Sesso HD, Lopez-Jimenez F, Buring JE, Gaziano JM. Alcohol consumption and cardiovascular disease mortality in hypertensive men. Arch Intern Med. 2004;164:623–628
  3. Camargo CA, Stampfer MJ, Glynn RJ, Grodstein F, Gaziano JM, Manson JE, et al. Moderate alcohol consumption and risk for angina pectoris or myocardial infarction in U.S. male physicians. Ann Intern Med. 1997;126:372–375
  4. Djousse L, Gaziano JM. Alcohol consumption and risk of heart failure in the Physicians' Health Study I. Circulation. 2007;115:34–39
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  9. Greenfield JR, Samaras K, Hayward CS, Chisholm DJ, Campbell LV. Beneficial postprandial effect of a small amount of alcohol on diabetes and cardiovascular risk factors: modification by insulin resistance. J Clin Endocrinol Metab. 2005;90:661–672
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  11. Gaziano JM, Buring JE, Breslow JL, Goldhaber SZ, Rosner B, VanDenburgh M, et al. Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. N Engl J Med. 1993;329:1829–1834
  12. Mukamal K, Massaro J, Ault K, Mittleman M, Sutherland P, Lipinska I, et al. Alcohol consumption and platelet activation and aggregation among women and men: the Framingham Offspring Study. Alcohol Clin Exp Res. 2005;29:1906–1912
  13. Klatsky A, Koplik S, Gunderson E, Kipp H, Friedman G. Sequelae of systemic hypertension in alcohol abstainers, light drinkers, and heavy drinkers. Am J Cardiol. 2006;98:1063–1068
  14. Rimm EB, Giovannucci EL, Willett WC, Colditz GA, Ascherio A, Rosner B, et al. Prospective study of alcohol consumption and risk of coronary disease in men. Lancet. 1991;338:464–468
  15. Stampfer M, Colditz G, Willett W, Speizer F, Hennekens C. A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. N Engl J Med. 1988;319:267–273
  16. Di Castelnuovo A, Costanzo S, Bagnardi V, Donati MB, Iacoviello L, de Gaetano G. Alcohol dosing and total mortality in men and women: an updated meta-analysis of 34 prospective studies. Arch Intern Med. 2006;166:2437–2445
  17. Thun MJ, Peto R, Lopez AD, Monaco JH, Henley SJ, Heath CW, et al. Alcohol consumption and mortality among middle-aged and elderly U.S. adults. N Engl J Med. 1997;337:1705–1714
  18. Sesso HD, Cook NR, Buring JE, Manson JE, Gaziano JM. Alcohol consumption and the risk of hypertension in women and men. Hypertension. 2008;51:1080–1087

 The Physicians' Health Study is supported by Grants CA-34944, CA-40360, CA-097193, HL-26490, and HL-34595 from the National Institute of Health, Bethesda, Maryland.

PII: S0002-9149(09)01103-5

doi: 10.1016/j.amjcard.2009.05.036

American Journal of Cardiology
Volume 104, Issue 7 , Pages 932-935 , 1 October 2009

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