American Journal of Cardiology
Volume 104, Issue 6 , Pages 818-822 , 15 September 2009

Cholesteryl Ester Transfer Protein, Coronary Calcium, and Intima-Media Thickness of the Carotid Artery in Middle-Age Japanese Men

  • Tomonori Okamura, MD

      Affiliations

    • Preventive Cardiology, National Cardiovascular Center, Suita, Osaka, Japan
    • Shiga University of Medical Science, Otsu, Shiga, Japan
    • Corresponding Author InformationCorresponding author: Tel: (+81) 6-6833-5012, ext. 2228 or 2188; fax: (+81) 6-6833-5300
    • ,
  • Akira Sekikawa, MD

      Affiliations

    • University of Pittsburgh, Pittsburgh, Pennsylvania
    • ,
  • Takashi Kadowaki, MD

      Affiliations

    • Shiga University of Medical Science, Otsu, Shiga, Japan
    • ,
  • Aiman El-Saed, MD

      Affiliations

    • University of Pittsburgh, Pittsburgh, Pennsylvania
    • ,
  • Robert D. Abbott, PhD

      Affiliations

    • University of Virginia, Charlottesville, Virginia
    • ,
  • J. David Curb, MD

      Affiliations

    • University of Hawaii, Honolulu, Hawaii
    • ,
  • Daniel Edmundowicz, MD

      Affiliations

    • University of Pittsburgh, Pittsburgh, Pennsylvania
    • ,
  • Yasuyuki Nakamura, MD

      Affiliations

    • Kyoto Women's University, Kyoto, Kyoto, Japan
    • ,
  • Kiyoshi Murata, MD

      Affiliations

    • Shiga University of Medical Science, Otsu, Shiga, Japan
    • ,
  • Atsunori Kashiwagi, MD

      Affiliations

    • Shiga University of Medical Science, Otsu, Shiga, Japan
    • ,
  • Kim Sutton-Tyrrell, DrPH

      Affiliations

    • University of Pittsburgh, Pittsburgh, Pennsylvania
    • ,
  • Rhobert W. Evans, PhD

      Affiliations

    • University of Pittsburgh, Pittsburgh, Pennsylvania
    • ,
  • Joseph M. Zmuda, PhD

      Affiliations

    • University of Pittsburgh, Pittsburgh, Pennsylvania
    • ,
  • Hiroshi Maegawa, MD

      Affiliations

    • Shiga University of Medical Science, Otsu, Shiga, Japan
    • ,
  • Atsushi Hozawa, MD

      Affiliations

    • Shiga University of Medical Science, Otsu, Shiga, Japan
    • ,
  • Ken-Ichi Mitsunami, MD

      Affiliations

    • Shiga University of Medical Science, Otsu, Shiga, Japan
    • ,
  • Yoshihiko Nishio, PhD

      Affiliations

    • Shiga University of Medical Science, Otsu, Shiga, Japan
    • ,
  • Iva Miljkovic-Gacic, MD

      Affiliations

    • University of Pittsburgh, Pittsburgh, Pennsylvania
    • ,
  • Minoru Horie, MD

      Affiliations

    • Shiga University of Medical Science, Otsu, Shiga, Japan
    • ,
  • Naomi Miyamatsu, MD

      Affiliations

    • Shiga University of Medical Science, Otsu, Shiga, Japan
    • ,
  • Yoshitaka Murakami, PhD

      Affiliations

    • Shiga University of Medical Science, Otsu, Shiga, Japan
    • ,
  • Lewis H. Kuller, MD

      Affiliations

    • University of Pittsburgh, Pittsburgh, Pennsylvania
    • ,
  • Hirotsugu Ueshima, MD

      Affiliations

    • Shiga University of Medical Science, Otsu, Shiga, Japan

Received 31 March 2009 ,Revised 2 May 2009 ,Accepted 2 May 2009.

References 

  1. Tall AR. Plasma cholesteryl ester transfer protein. J Lipid Res. 1993;34:1255–1274
  2. Rumana N, Kita Y, Turin TC, Murakami Y, Sugihara H, Morita Y, et al. Seasonal pattern of incidence and case fatality of acute myocardial infarction in a Japanese population (from the Takashima AMI Registry, 1988–2003). Am J Cardiol. 2008;102:1307–1311
  3. Okamura T, Kokubo Y, Watanabe M, Higashiyama A, Miyamoto Y, Yoshimasa Y, et al. Low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol and the incidence of cardiovascular disease in an urban Japanese cohort study: the Suita study. Atherosclerosis. 2009;203:587–592
  4. Inazu A, Jiang XC, Haraki T, Yagi K, Kamon N, Koizumi J, et al. Genetic cholesteryl ester transfer protein deficiency caused by two prevalent mutations as a major determinant of increased levels of high density lipoprotein cholesterol. J Clin Invest. 1994;94:1872–1882
  5. Sekikawa A, Ueshima H, Kadowaki T, El-Saed A, Okamura T, Takamiya T, et al. Less subclinical atherosclerosis in Japanese men in Japan than in white men in the United States in the post-World War II birth cohort. Am J Epidemiol. 2007;165:617–624
  6. Okamura T, Kadowaki T, Sekikawa A, Murata K, Miyamatsu N, Nakamura Y, et al. Alcohol consumption and coronary artery calcium in middle-aged Japanese men. Am J Cardiol. 2006;98:141–144
  7. Nakamura Y, Ueno Y, Tamaki S, Kadowaki T, Okamura T, Kita Y, et al. Fish consumption and early atherosclerosis in middle-aged men. Metabolism. 2007;56:1060–1064
  8. Sekikawa A, Curb JD, Ueshima H, El-Saed A, Kadowaki T, Abbott RD, et al. Marine-derived n-3 fatty acids and atherosclerosis in Japanese, Japanese Americans, and whites: a cross-sectional study. J Am Coll Cardiol. 2008;52:417–424
  9. Sasai K, Okumura-Noji K, Hibino T, Ikeuchi R, Sakuma N, Fujinami T, et al. Human cholesteryl ester transfer protein measured by enzyme-linked immunosorbent assay with two monoclonal antibodies against rabbit cholesteryl ester transfer protein: plasma cholesteryl ester transfer protein and lipoproteins among Japanese hypercholesterolemic patients. Clin Chem. 1998;44:1466–1473
  10. Kokubo Y, Okamura T, Yoshimasa Y, Miyamoto Y, Kawanishi K, Kotani Y, et al. Impact of metabolic syndrome components on the incidence of cardiovascular disease in a general urban Japanese population: the Suita study. Hypertens Res. 2008;31:2027–2035
  11. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15:827–832
  12. Thompson T, Sutton-Tyrrell K, Wildman R. Continuous quality assessment programs can improve carotid duplex scan quality. J vasc Technol. 2001;25:33–39
  13. Barter PJ, Brewer HB, Chapman MJ, Hennekens CH, Rader DJ, Tall AR. Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis. Arterioscler Thromb Vasc Biol. 2003;23:160–167
  14. Hirano K, Yamashita S, Nakajima N, Arai T, Maruyama T, Yoshida Y, et al. Genetic cholesteryl ester transfer protein deficiency is extremely frequent in the Omagari area of Japan: marked hyperalphalipoproteinemia caused by CETP gene mutation is not associated with longevity. Arterioscler Thromb Vasc Biol. 1997;17:1053–1059
  15. Boekholdt SM, Kuivenhoven JA, Wareham NJ, Peters RJ, Jukema JW, Luben R, et al. Plasma levels of cholesteryl ester transfer protein and the risk of future coronary artery disease in apparently healthy men and women: the prospective EPIC (European Prospective Investigation into Cancer and nutrition)-Norfolk population study. Circulation. 2004;110:1418–1423
  16. Föger B, Luef G, Ritsch A, Schmidauer C, Doblinger A, Lechleitner M, et al. Relationship of high-density lipoprotein subfractions and cholesteryl ester transfer protein in plasma to carotid artery wall thickness. J Mol Med. 1995;73:369–372
  17. Zhuang Y, Wang J, Qiang H, Li Y, Lui X, Li L, et al. Serum cholesteryl ester transfer protein concentrations in healthy Chinese subjects and cardio-cerebrovascular disease patients. Clinica Chim Acta. 2001;305:19–25
  18. Klerkx AH, de Grooth GJ, Zwinderman AH, Jukema JW, Kuivenhoven JA, Kastelein JJ. Cholesteryl ester transfer protein concentration is associated with progression of atherosclerosis and response to pravastatin in men with coronary artery disease (REGRESS). Eur J Clin Invest. 2004;34:21–28
  19. Colhoun HM, Scheek LM, Rubens MB, Van Gent T, Underwood SR, Fuller JH, et al. Lipid transfer protein activities in type 1 diabetic patients without renal failure and nondiabetic control subjects and their association with coronary artery calcification. Diabetes. 2001;50:652–659
  20. de Vries R, Perton FG, Dallinga-Thie GM, van Roon AM, Wolffenbuttel BH, van Tol A, et al. Plasma cholesteryl ester transfer is a determinant of intima-media thickness in type 2 diabetic and nondiabetic subjects: role of CETP and triglycerides. Diabetes. 2005;54:3554–2559
  21. Barter PJ, Caulfield M, Eriksson M, Grundy SM, Kastelein JJ, Komajda M, et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med. 2007;357:2109–2122
  22. Nissen SE, Tardif JC, Nicholls SJ, Revkin JH, Shear CL, Duggan WT, et al. Effect of torcetrapib on the progression of coronary atherosclerosis. N Engl J Med. 2007;356:1304–1316
  23. Bots ML, Visseren FL, Evans GW, Riley WA, Revkin JH, Tegeler CH, et al. Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial. Lancet. 2007;370:153–160
  24. Vergeer M, Bots ML, van Leuven SI, Basart DC, Sijbrands EJ, Evans GW, et al. Cholesteryl ester transfer protein inhibitor torcetrapib and off-target toxicity: a pooled analysis of the rating atherosclerotic disease change by imaging with a new CETP inhibitor (RADIANCE) trials. Circulation. 2008;118:2515–2522
  25. Curb JD, Abbott RD, Rodriguez BL, Masaki K, Chen R, Sharp DS, et al. A prospective study of HDL-C and cholesteryl ester transfer protein gene mutations and the risk of coronary heart disease in the elderly. J Lipid Res. 2004;45:948–953
  26. Hirano K, Yamashita S, Nakajima N, Arai T, Maruyama T, Yoshida Y, et al. Genetic cholesteryl ester transfer protein deficiency is extremely frequent in the Omagari area of Japan: marked hyperalphalipoproteinemia caused by CETP gene mutation is not associated with longevity. Arterioscler Thromb Vasc Biol. 1997;17:1053–1059
  27. Moriyama Y, Okamura T, Inazu A, Doi M, Iso H, Mouri Y, et al. A low prevalence of coronary heart disease among subjects with increased high-density lipoprotein cholesterol levels, including those with plasma cholesteryl ester transfer protein deficiency. Prev Med. 1998;27(5 Pt 1):659–667
  28. Nicholls SJ, Tuzcu EM, Brennan DM, Tardif JC, Nissen SE. Cholesteryl ester transfer protein inhibition, high-density lipoprotein raising, and progression of coronary atherosclerosis: insights from ILLUSTRATE (Investigation of Lipid Level Management Using Coronary Ultrasound to Assess Reduction of Atherosclerosis by CETP Inhibition and HDL Elevation). Circulation. 2008;118:2506–2514
  29. van Venrooij FV, Stolk RP, Banga JD, Sijmonsma TP, van Tol A, Erkelens DW, et al. Common cholesteryl ester transfer protein gene polymorphisms and the effect of atorvastatin therapy in type 2 diabetes. Diabetes Care. 2003;26:1216–1223

 This research was supported by Grants R01 HL68200 and HL071561 from the National Institutes of Health, Bethesda, Maryland; by a Grant-in-Aid for Scientific Research, Grants C18590595 and C20590670, from the Japan Society for the Promotion of Science, Tokyo, Japan; and by a Grant-in-Aid for Scientific Research, Grant A13307016, by the Japanese Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan.

PII: S0002-9149(09)01056-X

doi: 10.1016/j.amjcard.2009.05.021

American Journal of Cardiology
Volume 104, Issue 6 , Pages 818-822 , 15 September 2009

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