American Journal of Cardiology
Volume 104, Issue 5 , Pages 665-670 , 1 September 2009

T-Wave Alternans, Air Pollution and Traffic in High-Risk Subjects

  • Antonella Zanobetti, PhD

      Affiliations

    • Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts
    • Corresponding Author InformationCorresponding author: Tel: 617-384-8751; fax: 617-384-8859
    • ,
  • Peter H. Stone, MD

      Affiliations

    • Cardiology Division, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts
    • ,
  • Frank E. Speizer, MD

      Affiliations

    • Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts
    • Channing Laboratory, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts
    • ,
  • Joel D. Schwartz, PhD

      Affiliations

    • Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts
    • ,
  • Brent A. Coull, PhD

      Affiliations

    • Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts
    • Environmental Statistics Program, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts
    • ,
  • Helen H. Suh, ScD

      Affiliations

    • Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts
    • ,
  • Bruce D. Nearing, PhD

      Affiliations

    • Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    • ,
  • Murray A. Mittleman, MD, DrPH

      Affiliations

    • Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    • ,
  • Richard L. Verrier, PhD

      Affiliations

    • Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    • ,
  • Diane R. Gold, MD, MPH

      Affiliations

    • Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts
    • Channing Laboratory, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts

Received 23 March 2009 ,Revised 26 April 2009 ,Accepted 26 April 2009.

  • Image Result

    Twenty-four-hour estimated circadian pattern of TWA-MAX, plotted as the mean of TWA-MAX values for each 0.5-hour period of the day, controlling for subject, day of the week, being in traffic, average

    Twenty-four-hour estimated circadian pattern of TWA-MAX, plotted as the mean of TWA-MAX values for each 0.5-hour period of the day, controlling for subject, day of the week, being in traffic, average heart rate, hour of the day, date, mean temperature, and BC. The curve and pointwise 95% confidence intervals (dotted line) were estimated using a penalized spline.

  • Image Result
    Percentage change in TWA-MAX for increasing averaging times for ambient PM2.5 and BC. PM2.5 effects are scaled to 10 μg/m3; BC effects are scaled to 1 μg/m3.

    Percentage change in TWA-MAX for increasing averaging times for ambient PM2.5 and BC. PM2.5 effects are scaled to 10 μg/m3; BC effects are scaled to 1 μg/m3.

 This work was supported in part by Grant P01 ES009825, NIEHS-00002, from the National Institute of Environment Health Sciences, Research Triangle Park, North Carolina; Grant R832416-01-0 from the Environmental Protection Agency, Washington, District of Columbia.

PII: S0002-9149(09)01014-5

doi: 10.1016/j.amjcard.2009.04.046

American Journal of Cardiology
Volume 104, Issue 5 , Pages 665-670 , 1 September 2009

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