American Journal of Cardiology
Volume 104, Issue 5 , Pages 713-720 , 1 September 2009

Prospective Echocardiography Assessment of Pulmonary Hypertension and Its Potential Etiologies in Children With Sickle Cell Disease†

  • Niti Dham, MD

      Affiliations

    • Department of Cardiology, Children's National Medical Center, Washington, District of Columbia
    • ,
  • Gregory Ensing, MD

      Affiliations

    • Pediatric Cardiology Division, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan
    • ,
  • Caterina Minniti, MD

      Affiliations

    • Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland
    • ,
  • Andrew Campbell, MD

      Affiliations

    • Hematology Division, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan
    • ,
  • Manuel Arteta, MD

      Affiliations

    • Pulmonary Division, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan
    • ,
  • Sohail Rana, MD

      Affiliations

    • Department of Pediatrics and Child Health, Howard University, Washington, District of Columbia
    • ,
  • Deepika Darbari, MD

      Affiliations

    • Department of Hematology, Children's National Medical Center, Washington, District of Columbia
    • ,
  • Mehdi Nouraie, MD, PhD

      Affiliations

    • Center for Sickle Cell Disease, Howard University College of Medicine, Washington, District of Columbia
    • ,
  • Onyinye Onyekwere, MD

      Affiliations

    • Center for Sickle Cell Disease, Howard University College of Medicine, Washington, District of Columbia
    • ,
  • Malgorzata Lasota, RDCS

      Affiliations

    • Department of Cardiology, Children's National Medical Center, Washington, District of Columbia
    • ,
  • Gregory J. Kato, MD

      Affiliations

    • Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland
    • ,
  • Mark T. Gladwin, MD

      Affiliations

    • Department of Pulmonary, Allergy and Critical Care Medicine and Hemostasis and Vascular Biology Research Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    • ,
  • Oswaldo Castro, MD

      Affiliations

    • Center for Sickle Cell Disease, Howard University College of Medicine, Washington, District of Columbia
    • ,
  • Victor Gordeuk, MD

      Affiliations

    • Center for Sickle Cell Disease, Howard University College of Medicine, Washington, District of Columbia
    • ,
  • Craig Sable, MD

      Affiliations

    • Department of Cardiology, Children's National Medical Center, Washington, District of Columbia
    • Corresponding Author InformationCorresponding author: Tel: 202-476-2020; fax: 202-476-5700

Received 17 February 2009 ,Revised 26 April 2009 ,Accepted 26 April 2009.

  • Image Result

    Distribution of TRV in controls and patients with SCD in unadjusted analysis (left) and analysis adjusted for hemoglobin (right). Crosses indicate mean values.

    Distribution of TRV in controls and patients with SCD in unadjusted analysis (left) and analysis adjusted for hemoglobin (right). Crosses indicate mean values.

  • Image Result

    Distribution of pulmonary vascular resistance in controls and patients with SCD in unadjusted analysis (left) and analysis adjusted for hemoglobin (right). Crosses indicate mean values.

    Distribution of pulmonary vascular resistance in controls and patients with SCD in unadjusted analysis (left) and analysis adjusted for hemoglobin (right). Crosses indicate mean values.

  • Image Result

    Frequency distribution of pulmonary vascular resistance in patients with SCD grouped by TRV category.

    Frequency distribution of pulmonary vascular resistance in patients with SCD grouped by TRV category.

  • Image Result

    Correlation between left ventricular end-diastolic dimension z score and TRV in patients with SCD. CI = confidence interval; LVIDd = left ventricular internal dimension in diastole.

    Correlation between left ventricular end-diastolic dimension z score and TRV in patients with SCD. CI = confidence interval; LVIDd = left ventricular internal dimension in diastole.

  • Image Result

    Correlation between mitral inflow E wave/tissue Doppler E wave ratio (Etdi) and TRV in patients with SCD. CI = confidence interval.

    Correlation between mitral inflow E wave/tissue Doppler E wave ratio (Etdi) and TRV in patients with SCD. CI = confidence interval.

 This study was supported in part by Grants 2 R25 HL003679-08 and 1 R01 HL079912-02 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland; by Howard University General Clinical Research Center Grant 2MOI RR10284-10 from the National Center for Research Resources, National Institutes of Health, Bethesda, Maryland; and by the Intramural Research Program of the National Institutes of Health.

PII: S0002-9149(09)01002-9

doi: 10.1016/j.amjcard.2009.04.034

American Journal of Cardiology
Volume 104, Issue 5 , Pages 713-720 , 1 September 2009

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