American Journal of Cardiology
Volume 104, Issue 4 , Pages 464-469 , 15 August 2009

Association of Leukocyte Subtype Counts With Coronary Atherosclerotic Regression Following Pravastatin Treatment

  • Shigemasa Tani, MD

      Affiliations

    • Department of Cardiology, Nihon University, Surugadai Hospital, Tokyo, Japan
    • Division of Cardiovascular Medicine, Department of Medicine, Nihon University, School of Medicine, Tokyo, Japan
    • Corresponding Author InformationCorresponding author: Tel: 81-3-3293-1711; fax: +81-3-3295-1859
    • ,
  • Ken Nagao, MD

      Affiliations

    • Department of Cardiology, Nihon University, Surugadai Hospital, Tokyo, Japan
    • Division of Cardiovascular Medicine, Department of Medicine, Nihon University, School of Medicine, Tokyo, Japan
    • ,
  • Takeo Anazawa, MD

      Affiliations

    • Department of Cardiology, Nihon University, Surugadai Hospital, Tokyo, Japan
    • Division of Cardiovascular Medicine, Department of Medicine, Nihon University, School of Medicine, Tokyo, Japan
    • ,
  • Hirofumi Kawamata, MD

      Affiliations

    • Department of Cardiology, Nihon University, Surugadai Hospital, Tokyo, Japan
    • Division of Cardiovascular Medicine, Department of Medicine, Nihon University, School of Medicine, Tokyo, Japan
    • ,
  • Shingo Furuya, MD

      Affiliations

    • Department of Cardiology, Nihon University, Surugadai Hospital, Tokyo, Japan
    • Division of Cardiovascular Medicine, Department of Medicine, Nihon University, School of Medicine, Tokyo, Japan
    • ,
  • Hiroshi Takahashi, MD

      Affiliations

    • Department of Cardiology, Nihon University, Surugadai Hospital, Tokyo, Japan
    • Division of Cardiovascular Medicine, Department of Medicine, Nihon University, School of Medicine, Tokyo, Japan
    • ,
  • Kiyoshi Iida

      Affiliations

    • Department of Cardiology, Nihon University, Surugadai Hospital, Tokyo, Japan
    • Division of Cardiovascular Medicine, Department of Medicine, Nihon University, School of Medicine, Tokyo, Japan
    • ,
  • Michiaki Matsumoto, MD

      Affiliations

    • Department of Cardiology, Nihon University, Surugadai Hospital, Tokyo, Japan
    • Division of Cardiovascular Medicine, Department of Medicine, Nihon University, School of Medicine, Tokyo, Japan
    • ,
  • Takehiko Washio, MD

      Affiliations

    • Department of Cardiology, Nihon University, Surugadai Hospital, Tokyo, Japan
    • Division of Cardiovascular Medicine, Department of Medicine, Nihon University, School of Medicine, Tokyo, Japan
    • ,
  • Narimichi Kumabe, MD

      Affiliations

    • Department of Cardiology, Nihon University, Surugadai Hospital, Tokyo, Japan
    • Division of Cardiovascular Medicine, Department of Medicine, Nihon University, School of Medicine, Tokyo, Japan
    • ,
  • Atsushi Hirayama, MD

      Affiliations

    • Division of Cardiovascular Medicine, Department of Medicine, Nihon University, School of Medicine, Tokyo, Japan

Received 2 February 2009 ,Revised 6 April 2009 ,Accepted 6 April 2009.

References 

  1. Ross R. Atherosclerosis—an inflammatory disease. N Engl J Med. 1999;340:115–126
  2. Freidman GD, Klatsky AL, Siegelaub AB. The leukocyte count as a predictor of myocardial infarction. N Engl J Med. 1974;290:1275–1278
  3. Madjid M, Awan I, Willerson JT, Casscells SW. Leukocyte count and coronary heart disease: implications for risk assessment. J Am Coll Cardiol. 2004;44:1945–1956
  4. Salonen R, Salonen JT. Progression of carotid atherosclerosis and its determinants: a population-based ultrasonography study. Atherosclerosis. 1990;81:33–40
  5. Gerrity RG. The role of the monocyte in atherogenesis: I (Transition of blood-borne monocytes into foam cells in fatty lesions). Am J Pathol. 1981;103:181–190
  6. Gerrity RG. The role of the monocyte in atherogenesis: II (Migration of foam cells from atherosclerotic lesions). Am J Pathol. 1981;103:191–200
  7. Moreno PR, Falk E, Palacios IF, Newell JB, Fuster V, Fallon JT. Macrophage infiltration in acute coronary syndromes (Implications for plaque rupture). Circulation. 1994;90:775–778
  8. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO, Criqui M, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107:499–511
  9. Teramoto T, Sasaki J, Ueshima H, Egusa G, Kinoshita M, Shimamoto K, et al. Treatment—therapeutic lifestyle modification. J Atheroscler Thromb. 2008;15:109–115
  10. Ishikawa K, Tani S, Watanabe I, Matsumoto M, Furukawa K, Nomoto K, et al. Effect of pravastatin on coronary plaque volume. Am J Cardiol. 2003;92:975–977
  11. Tani S, Watanabe I, Anazawa T, Kawamata H, Tachibana E, Furukawa K, et al. Effect of pravastatin on malondialdehyde-modified low-density lipoprotein levels and coronary plaque regression as determined by three-dimensional intravascular ultrasound. Am J Cardiol. 2005;96:1089–1094
  12. Lee AJ, Mowbray PI, Lowe GD, Rumley A, Fowkes FG, Allan PL. Blood viscosity and elevated carotid intima-media thickness in men and women: the Edinburgh Artery Study. Circulation. 1998;97:1467–1473
  13. Elkind MS, Cheng J, Boden-Albala B, Paik MC, Sacco RL. Elevated white blood cell count and carotid plaque thickness: the northern Manhattan stroke study. Stroke. 2001;32:842–849
  14. van der Meer IM, de Maat MPM, Bots ML, Breteler MMB, Meijer J, Kiliaan AJ, et al. Inflammatory mediators and cell adhesion molecules as indicators of severity of atherosclerosis: the Rotterdam Study. Arterioscler Thromb Vasc Biol. 2002;22:838–842
  15. Hunt KJ, Pankow JS, Offenbacher S, Kritchevsky SB, Duncan BB, Shahar E, et al. B-mode ultrasound-detected carotid artery lesions with and without acoustic shadowing and their association with markers of inflammation and endothelial activation: the atherosclerosis risk in communities study. Atherosclerosis. 2002;162:145–155
  16. Chapman CM, Beilby JP, McQuillan BM, Thompson PL, Hung J. Monocyte count, but not C-reactive protein or interleukin-6, is an independent risk marker for subclinical carotid atherosclerosis. Stroke. 2004;35:1619–1624
  17. Nissen SE, Tuzcu EM, Schoenhagen P, Crowe T, Sasiela WJ, Tsai J, et al. Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N Engl J Med. 2005;352:29–38
  18. Bickel C, Rupprecht HJ, Blankenberg S, Espiniola-Klein C, Schlitt A, Rippin G, et al. Relation of markers of inflammation (C-reactive protein, fibrinogen, von Willebrand factor, and leukocyte count) and statin therapy to long-term mortality in patients with angiographically proven coronary artery disease. Am J Cardiol. 2002;89:901–908
  19. Shah PK, Kaul S, Nilsson J, Cercek B. Exploiting the vascular protective effects of high-density lipoprotein and its apolipoproteins: an idea whose time for testing is coming (part I). Circulation. 2001;104:2376–2383
  20. Nissen SE, Nicholls SJ, Sipahi I, Libby P, Raichlen JS, Ballantyne CM, et al. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA. 2006;295:1556–1565
  21. Nakamura H, Arakawa K, Itakura H, Kitabatake A, Goto Y, Toyota T, et al. Primary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study): a prospective randomised controlled trial. Lancet. 2006;368:1155–1163
  22. Takayama T, Hiro T, Yamagishi M, Daida H, Saito S, Yamaguchi T, et al. Rationale and design for a study using intravascular ultrasound to evaluate effects of rosuvastatin on coronary artery atheroma in Japanese subjects: COSMOS study (Coronary Atherosclerosis Study Measuring Effects of Rosuvastatin Using Intravascular Ultrasound in Japanese Subjects). Circ J. 2007;71:271–275
  23. Miyauchi K, Kimura T, Morimoto T, Nakagawa Y, Yamagishi M, Ozaki Y, et al. Japan assessment of pitavastatin and atorvastatin in acute coronary syndrome (JAPAN-ACS): rationale and design. Circ J. 2006;70:1624–1628

 This study was supported in part by a 2007 Nihon University Research Grant for Assistants and Young Researchers, Tokyo, Japan.

PII: S0002-9149(09)00911-4

doi: 10.1016/j.amjcard.2009.04.009

American Journal of Cardiology
Volume 104, Issue 4 , Pages 464-469 , 15 August 2009

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