American Journal of Cardiology
Volume 104, Issue 4 , Pages 470-474 , 15 August 2009

Prognostic Value of Admission Fasting Glucose Levels in Patients With Acute Coronary Syndrome

  • Louis Kolman, MD

      Affiliations

    • Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan
    • ,
  • Yu-Chen Hu, MD

      Affiliations

    • California Pacific Medical Center, San Francisco, California
    • ,
  • Daniel G. Montgomery, BS

      Affiliations

    • Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, Michigan
    • ,
  • Kelly Gordon

      Affiliations

    • Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, Michigan
    • ,
  • Kim A. Eagle, MD

      Affiliations

    • Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan
    • Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, Michigan
    • University of Michigan Health System, University of Michigan, Ann Arbor, Michigan
    • ,
  • Elizabeth A. Jackson, MD, MPH

      Affiliations

    • Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan
    • Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, Michigan
    • University of Michigan Health System, University of Michigan, Ann Arbor, Michigan
    • Corresponding Author InformationCorresponding author: Tel: (734) 998-7411; fax: (734) 998-9587

Received 16 February 2009 ,Revised 6 April 2009 ,Accepted 6 April 2009.

References 

  1. Latchamsetty R, Fang J, Kline-Rogers E, Mukherjee D, Otten RF, LaBounty TM, et al. Prognostic value of transient and sustained increase in in-hospital creatinine on outcomes of patients admitted with acute coronary syndrome. Am J Cardiol. 2007;99:939–942
  2. Fox KA, Dabbous OH, Goldberg RJ, Pieper KS, Eagle KA, Van de Werf F, et al. Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE). BMJ. 2006;333:1091
  3. Yan AT, Yan RT, Tan M, Eagle KA, Granger CB, Dabbous OH, et al. In-hospital revascularization and one-year outcome of acute coronary syndrome patients stratified by the GRACE risk score. Am J Cardiol. 2005;96:913–916
  4. Granger CB, Goldberg RJ, Dabbous O, Pieper KS, Eagle KA, Cannon CP, et al. Predictors of hospital mortality in the global registry of acute coronary events. Arch Intern Med. 2003;163:2345–2353
  5. Tang EW, Wong CK, Herbison P. Global Registry of Acute Coronary Events (GRACE) hospital discharge risk score accurately predicts long-term mortality post acute coronary syndrome. Am Heart J. 2007;153:29–35
  6. Meier JJ, Deifuss S, Klamann A, Launhardt V, Schmiegel WH, Nauck MA. Plasma glucose at hospital admission and previous metabolic control determine myocardial infarct size and survival in patients with and without type 2 diabetes: the Langendreer Myocardial Infarction and Blood Glucose in Diabetic Patients Assessment (LAMBDA). Diab Care. 2005;28:2551–2553
  7. Wahab NN, Cowden EA, Pearce NJ, Gardner MJ, Merry H, Cox JL. Is blood glucose an independent predictor of mortality in acute myocardial infarction in the thrombolytic era?. J Am Coll Cardiol. 2002;40:1748–1754
  8. Stranders I, Diamant M, van Gelder RE, Spruijt HJ, Twisk JW, Heine RJ, et al. Admission blood glucose level as risk indicator of death after myocardial infarction in patients with and without diabetes mellitus. Arch Intern Med. 2004;164:982–988
  9. Vivas D, Garcia-Rubira JC, Gonzalez-Ferrer JJ, Nunez-Gil I, del Prado N, Fernandez-Ortiz A, et al. [Prognostic value of first fasting glucose measurement compared with admission glucose level in patients with acute coronary syndrome]. Rev Esp Cardiol. 2008;61:458–464
  10. Suleiman M, Hammerman H, Boulos M, Kapeliovich MR, Suleiman A, Agmon Y, et al. Fasting glucose is an important independent risk factor for 30-day mortality in patients with acute myocardial infarction: a prospective study. Circulation. 2005;111:754–760
  11. Cao JJ, Hudson M, Jankowski M, Whitehouse F, Weaver WD. Relation of chronic and acute glycemic control on mortality in acute myocardial infarction with diabetes mellitus. Am J Cardiol. 2005;96:183–186
  12. Otten R, Kline-Rogers E, Meier DJ, Dumasia R, Fang J, May N, et al. Impact of pre-diabetic state on clinical outcomes in patients with acute coronary syndrome. Heart. 2005;91:1466–1468
  13. Capes SE, Hunt D, Malmberg K, Gerstein HC. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet. 2000;355:773–778
  14. Hadjadj S, Coisne D, Mauco G, Ragot S, Duengler F, Sosner P, et al. Prognostic value of admission plasma glucose and HbA in acute myocardial infarction. Diabet Med. 2004;21:305–310
  15. Petursson P, Herlitz J, Caidahl K, Gudbjornsdottir S, Karlsson T, Perers E, et al. Admission glycaemia and outcome after acute coronary syndrome. Int J Cardiol. 2007;116:315–320
  16. Sinnaeve PR, Steg PG, Fox KA, Van de Werf F, Montalescot G, Granger CB, et al. Association of elevated fasting glucose with increased short-term and 6-month mortality in ST-segment elevation and non-ST-segment elevation acute coronary syndromes: the Global Registry of Acute Coronary events. Arch Intern Med. 2009;169:402–409
  17. Kosiborod M, Inzucchi SE, Krumholz HM, Xiao L, Jones PG, Fiske S, et al. Glucometrics in patients hospitalized with acute myocardial infarction: defining the optimal outcomes-based measure of risk. Circulation. 2008;117:1018–1027
  18. Ainla T, Baburin A, Teesalu R, Rahu M. The association between hyperglycaemia on admission and 180-day mortality in acute myocardial infarction patients with and without diabetes. Diabet Med. 2005;22:1321–1325
  19. Clement S, Braithwaite SS, Magee MF, Ahmann A, Smith EP, Schafer RG, et al. Management of diabetes and hyperglycemia in hospitals. Diab Care. 2004;27:553–591
  20. Tenerz A, Nilsson G, Forberg R, Ohrvik J, Malmberg K, Berne C, et al. Basal glucometabolic status has an impact on long-term prognosis following an acute myocardial infarction in non-diabetic patients. J Intern Med. 2003;254:494–503
  21. Kosiborod M, Rathore SS, Inzucchi SE, Masoudi FA, Wang Y, Havranek EP, et al. Admission glucose and mortality in elderly patients hospitalized with acute myocardial infarction: implications for patients with and without recognized diabetes. Circulation. 2005;111:3078–3086
  22. Malmberg K DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group. Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. BMJ. 1997;314:1512–1515
  23. Malmberg K, Ryden L, Wedel H, Birkeland K, Bootsma A, Dickstein K, et al. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity. Eur Heart J. 2005;26:650–661

 This study was partly supported by unrestricted grants from the Mardigan Fund, Detroit, Michigan, Sanofi-Aventis, Bridgewater, New Jersey, and the Hewlett Foundation, Menlo Park, California. Dr. Jackson was supported by Grant K23 HL073310-01 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland.

PII: S0002-9149(09)00907-2

doi: 10.1016/j.amjcard.2009.04.006

American Journal of Cardiology
Volume 104, Issue 4 , Pages 470-474 , 15 August 2009

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