American Journal of Cardiology
Volume 104, Issue 4 , Pages 475-479 , 15 August 2009

Relation Between Myocardial Infarct Size and Ventricular Tachyarrhythmia Among Patients With Preserved Left Ventricular Ejection Fraction Following Fibrinolytic Therapy for ST-Segment Elevation Myocardial Infarction

  • Yuri B. Pride, MD

      Affiliations

    • Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
  • ,
  • Evan Appelbaum, MD

      Affiliations

    • Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
  • ,
  • Erin E. Lord, BA

      Affiliations

    • TIMI Study Group, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
  • ,
  • Sarah Sloan, MA, MS

      Affiliations

    • TIMI Study Group, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
  • ,
  • Christopher P. Cannon, MD

      Affiliations

    • TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
  • ,
  • Marc S. Sabatine, MD, MPH

      Affiliations

    • TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
  • ,
  • C. Michael Gibson, MS, MD

      Affiliations

    • Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    • TIMI Study Group, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    • Corresponding Author InformationCorresponding author: Tel: 617-525-6884; fax: 888-249-5261
  • ,
  • TIMI Study Group

Received 2 March 2009 ,Revised 6 April 2009 ,Accepted 6 April 2009.

References 

  1. Roberts R, Henry PD, Sobel BE. An improved basis for enzymatic estimation of infarct size. Circulation. 1975;52:743–754
  2. Shell WE, Kjekshus JK, Sobel BE. Quantitative assessment of the extent of myocardial infarction in the conscious dog by means of analysis of serial changes in serum creatine phosphokinase activity. J Clin Invest. 1971;50:2614–2625
  3. Sobel BE, Roberts R, Larson KB. Estimation of infarct size from serum MB creatine phosphokinase activity: applications and limitations. Am J Cardiol. 1976;37:474–485
  4. Grande P, Nielsen A, Wagner GS, Christiansen C. Quantitative influence of serum creatine kinase isoenzyme MB estimated infarct size and other prognostic variables on one year mortality after acute myocardial infarction. Br Heart J. 1985;53:9–15
  5. Dewhurst NG, Hannan WJ, Muir AL. Prognostic value of radionuclide ventriculography after myocardial infarction. Q J Med. 1980;49:479–490
  6. Kelly MJ, Thompson PL, Quinlan MF. Prognostic significance of left ventricular ejection fraction after acute myocardial infarction (A bedside radionuclide study). Br Heart J. 1985;53:16–24
  7. Shah PK, Pichler M, Berman DS, Singh BN, Swan HJ. Left ventricular ejection fraction determined by radionuclide ventriculography in early stages of first transmural myocardial infarction (Relation to short-term prognosis). Am J Cardiol. 1980;45:542–546
  8. Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, et al. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med. 2005;352:225–237
  9. Moss AJ, Zareba W, Hall WJ, Klein H, Wilber DJ, Cannom DS, et al. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med. 2002;346:877–883
  10. Hellermann JP, Goraya TY, Jacobsen SJ, Weston SA, Reeder GS, Gersh BJ, et al. Incidence of heart failure after myocardial infarction: is it changing over time?. Am J Epidemiol. 2003;157:1101–1107
  11. Sabatine MS, Cannon CP, Gibson CM, Lopez-Sendon JL, Montalescot G, Theroux P, et al. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med. 2005;352:1179–1189
  12. Sabatine MS, McCabe CH, Gibson CM, Cannon CP. Design and rationale of Clopidogrel as Adjunctive Reperfusion Therapy-Thrombolysis In Myocardial Infarction (CLARITY-TIMI) 28 trial. Am Heart J. 2005;149:227–233
  13. Dodge HT, Sheehan FH. Quantitative contrast angiography for assessment of ventricular performance in heart disease. J Am Coll Cardiol. 1983;1:73–81
  14. Nienhuis MB, Ottervanger JP, de Boer MJ, Dambrink JH, Hoorntje JC, Gosselink AT, et al. Prognostic importance of creatine kinase and creatine kinase-MB after primary percutaneous coronary intervention for ST-elevation myocardial infarction. Am Heart J. 2008;155:673–679
  15. Turer AT, Mahaffey KW, Gallup D, Weaver WD, Christenson RH, Every NR, et al. Enzyme estimates of infarct size correlate with functional and clinical outcomes in the setting of ST-segment elevation myocardial infarction. Curr Control Trials Cardiovasc Med. 2005;6:12
  16. Christenson RH, Vollmer RT, Ohman EM, Peck S, Thompson TD, Duh SH, et al. Relation of temporal creatine kinase-MB release and outcome after thrombolytic therapy for acute myocardial infarction (TAMI Study Group). Am J Cardiol. 2000;85:543–547
  17. Bello D, Fieno DS, Kim RJ, Pereles FS, Passman R, Song G, et al. Infarct morphology identifies patients with substrate for sustained ventricular tachycardia. J Am Coll Cardiol. 2005;45:1104–1108
  18. Schmidt A, Azevedo CF, Cheng A, Gupta SN, Bluemke DA, Foo TK, et al. Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction. Circulation. 2007;115:2006–2014
  19. Hackel DB, Reimer KA, Ideker RE, Mikat EM, Hartwell TD, Parker CB, et al Comparison of enzymatic and anatomic estimates of myocardial infarct size in man. Circulation. 1984;70:824–835
  20. Grande P, Christiansen C, Alstrup K. Comparison of ASAT, CK, CK-MB, and LD for the estimation of acute myocardial infarct size in man. Clin Chim Acta. 1983;128:329–335
  21. Grande P, Hansen BF, Christiansen C, Naestoft J. Estimation of acute myocardial infarct size in man by serum CK-MB measurements. Circulation. 1982;65:756–764
  22. Grande P, Christiansen C, Pedersen A. Influence of acute myocardial infarct size on acute and one-year mortality. Eur Heart J. 1983;4:20–25
  23. Grande P, Kiilerich S. Relationship between serum CK-MB-estimated acute myocardial infarct size and clinical complications. Acta Med Scand. 1984;215:355–362
  24. Sanz G, Castaner A, Betriu A, Magrina J, Roig E, Coll S, et al. Determinants of prognosis in survivors of myocardial infarction: a prospective clinical angiographic study. N Engl J Med. 1982;306:1065–1070
  25. Schulze RA, Humphries JO, Griffith LS, Ducci H, Achuff S, Baird MG, et al. Left ventricular and coronary angiographic anatomy (Relationship to ventricular irritability in the late hospital phase of acute myocardial infarction). Circulation. 1977;55:839–843
  26. Goff DC, Howard G, Wang CH, Folsom AR, Rosamond WD, Cooper LS, et al. Trends in severity of hospitalized myocardial infarction: the Atherosclerosis Risk in Communities (ARIC) study, 1987–1994. Am Heart J. 2000;139:874–880
  27. Hellermann JP, Reeder GS, Jacobsen SJ, Weston SA, Killian JM, Roger VL. Longitudinal trends in the severity of acute myocardial infarction: a population study in Olmsted County, Minnesota. Am J Epidemiol. 2002;156:246–253
  28. Buxton AE. Risk stratification for sudden death: do we need anything more than ejection fraction?. Card Electrophysiol Rev. 2003;7:434–437
  29. Wu KC, Zerhouni EA, Judd RM, Lugo-Olivieri CH, Barouch LA, Schulman SP, et al. Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction. Circulation. 1998;97:765–772

 The CLARITY-TIMI 28 study was supported by a grant from Sanofi-Aventis, Paris, France, and Bristol-Myers Squibb, Princeton, New Jersey.

PII: S0002-9149(09)00906-0

doi: 10.1016/j.amjcard.2009.04.005

American Journal of Cardiology
Volume 104, Issue 4 , Pages 475-479 , 15 August 2009