American Journal of Cardiology
Volume 104, Issue 3 , Pages 318-326 , 1 August 2009

Comparison of Dual-Energy Computed Tomography of the Heart With Single Photon Emission Computed Tomography for Assessment of Coronary Artery Stenosis and of the Myocardial Blood Supply

  • Balazs Ruzsics, MD, PhD

      Affiliations

    • Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina
  • ,
  • Florian Schwarz, MD

      Affiliations

    • Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina
  • ,
  • U. Joseph Schoepf, MD

      Affiliations

    • Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina
    • Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina
    • Corresponding Author InformationCorresponding author: Tel: (843) 876-7146; fax: (843) 876-3157
  • ,
  • Yeong Shyan Lee, MD

      Affiliations

    • Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina
    • Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore
  • ,
  • Gorka Bastarrika, MD, PhD

      Affiliations

    • Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina
    • Department of Radiology, University of Navarra, Pamplona, Spain
  • ,
  • Salvatore A. Chiaramida, MD

      Affiliations

    • Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina
  • ,
  • Philip Costello, MD

      Affiliations

    • Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina
  • ,
  • Peter L. Zwerner, MD

      Affiliations

    • Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina
    • Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina

References 

  1. Flohr TG, McCollough CH, Bruder H, Petersilka M, Gruber K, Suss C, et al. First performance evaluation of a dual-source CT (DSCT) system. Eur Radiol. 2006;16:256–268
  2. Heuschmid M, Burgstahler C, Reimann A, Brodoefel H, Mysal I, Haeberle E, et al. Usefulness of noninvasive cardiac imaging using dual-source computed tomography in an unselected population with high prevalence of coronary artery disease. Am J Cardiol. 2007;100:587–592
  3. Leber AW, Johnson T, Becker A, von Ziegler F, Tittus J, Nikolaou K, et al. Diagnostic accuracy of dual-source multi-slice CT-coronary angiography in patients with an intermediate pretest likelihood for coronary artery disease. Eur Heart J. 2007;28:2354–2360
  4. Ruzsics B, Lee H, Powers ER, Flohr TG, Costello P, Schoepf UJ. Images in cardiovascular medicine: myocardial ischemia diagnosed by dual-energy computed tomography: correlation with single-photon emission computed tomography. Circulation. 2008;117:1244–1245
  5. Ruzsics B, Lee H, Zwerner PL, Gebregziabher M, Costello P, Schoepf UJ. Dual-energy CT of the heart for diagnosing coronary artery stenosis and myocardial ischemia-initial experience. Eur Radiol. 2008;18:2414–2424
  6. Johnson TR, Krauss B, Sedlmair M, Grasruck M, Bruder H, Morhard D, et al. Material differentiation by dual energy CT: initial experience. Eur Radiol. 2007;17:1510–1517
  7. Einstein AJ, Moser KW, Thompson RC, Cerqueira MD, Henzlova MJ. Radiation dose to patients from cardiac diagnostic imaging. Circulation. 2007;116:1290–1305
  8. Schwarz F, Ruzsics B, Schoepf UJ, Bastarrika G, Chiaramida SA, Abro JA, et al. Dual-energy CT of the heart—principles and protocols. Eur J Radiol. 2008;68:423–433
  9. Riederer SJ, Mistretta CA. Selective iodine imaging using K-edge energies in computerized x-ray tomography. Med Phys. 1977;4:474–481
  10. Hachamovitch R, Berman DS, Kiat H, Cohen I, Cabico JA, Friedman J, et al. Exercise myocardial perfusion SPECT in patients without known coronary artery disease: incremental prognostic value and use in risk stratification. Circulation. 1996;93:905–914
  11. Klocke FJ, Baird MG, Lorell BH, Bateman TM, Messer JV, Berman DS, et al. ACC/AHA/ASNC guidelines for the clinical use of cardiac radionuclide imaging—executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASNC Committee to revise the 1995 guidelines for the clinical use of cardiac radionuclide imaging). Circulation. 2003;108:1404–1418
  12. Hendel RC, Patel MR, Kramer CM, Poon M, Hendel RC, Carr JC, et al. ACCF/ACR/SCCT/SCMR/ASNC/NASCI/SCAI/SIR 2006 appropriateness criteria for cardiac computed tomography and cardiac magnetic resonance imaging. J Am Coll Cardiol. 2006;48:1475–1497
  13. George RT, Jerosch-Herold M, Silva C, Kitagawa K, Bluemke DA, Lima JA, et al. Quantification of myocardial perfusion using dynamic 64-detector computed tomography. Invest Radiol. 2007;42:815–822
  14. Buecker A, Katoh M, Krombach GA, Spuentrup E, Bruners P, Gunther RW, et al. A feasibility study of contrast enhancement of acute myocardial infarction in multislice computed tomography: comparison with magnetic resonance imaging and gross morphology in pigs. Invest Radiol. 2005;40:700–704
  15. Mahnken AH, Katoh M, Bruners P, Spuentrup E, Wildberger JE, Gunther RW, et al. Acute myocardial infarction: assessment of left ventricular function with 16-detector row spiral CT versus MR imaging—study in pigs. Radiology. 2005;236:112–117
  16. George RT, Silva C, Cordeiro MA, DiPaula A, Thompson DR, McCarthy WF, et al. Multidetector computed tomography myocardial perfusion imaging during adenosine stress. J Am Coll Cardiol. 2006;48:153–160
  17. Nikolaou K, Sanz J, Poon M, Wintersperger BJ, Ohnesorge B, Rius T, et al. Assessment of myocardial perfusion and viability from routine contrast-enhanced 16-detector-row computed tomography of the heart: preliminary results. Eur Radiol. 2005;15:864–871
  18. Mahnken AH, Koos R, Katoh M, Wildberger JE, Spuentrup E, Buecker A, et al. Assessment of myocardial viability in reperfused acute myocardial infarction using 16-slice computed tomography in comparison to magnetic resonance imaging. J Am Coll Cardiol. 2005;45:2042–2047
  19. Lardo AC, Cordeiro MA, Silva C, Amado LC, George RT, Saliaris AP, et al. Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar. Circulation. 2006;113:394–404
  20. Mahnken AH, Bruners P, Muhlenbruch G, Emmerich M, Hohl C, Gunther RW, et al. Low tube voltage improves computed tomography imaging of delayed myocardial contrast enhancement in an experimental acute myocardial infarction model. Invest Radiol. 2007;42:123–129
  21. Johnson TR, Nikolaou K, Wintersperger BJ, Leber AW, von Ziegler F, Rist C, et al. Dual-source CT cardiac imaging: initial experience. Eur Radiol. 2006;16:1409–1415
  22. Nagao M, Matsuoka H, Kawakami H, Higashino H, Mochizuki T, Murase K, et al. Quantification of myocardial perfusion by contrast-enhanced 64-MDCT: characterization of ischemic myocardium. AJR Am J Roentgenol. 2008;191:19–25
  23. Baile EM, Pare PD, D'Yachkova Y, Carere RG. Effect of contrast media on coronary vascular resistance: contrast-induced coronary vasodilation. Chest. 1999;116:1039–1045
  24. Matsunari I, Haas F, Nguyen NT, Reidel G, Wolf I, Senekowitsch-Schmidtke R, et al. Comparison of sestamibi, tetrofosmin, and Q12 retention in porcine myocardium. J Nucl Med. 2001;42:818–823
  25. Glover DK, Ruiz M, Edwards NC, Cunningham M, Simanis JP, Smith WH, et al. Comparison between 201Tl and 99mTc sestamibi uptake during adenosine-induced vasodilation as a function of coronary stenosis severity. Circulation. 1995;91:813–820
  26. Gould RG, Lipton MJ, McNamara MT, Sievers RE, Koshold S, Higgins CB. Measurement of regional myocardial blood flow in dogs by ultrafast CT. Invest Radiol. 1988;23:348–353
  27. Bell MR, Lerman LO, Rumberger JA. Validation of minimally invasive measurement of myocardial perfusion using electron beam computed tomography and application in human volunteers. Heart. 1999;81:628–635
  28. Kalender WA, Perman WH, Vetter JR, Klotz E. Evaluation of a prototype dual-energy computed tomographic apparatus (I. Phantom studies). Med Phys. 1986;13:334–339
  29. Hausleiter J, Meyer T, Hadamitzky M, Huber E, Zankl M, Martinoff S, et al. Radiation dose estimates from cardiac multislice computed tomography in daily practice: impact of different scanning protocols on effective dose estimates. Circulation. 2006;113:1305–1310
  30. Mettler FA, Huda W, Yoshizumi TT, Mahesh M. Effective doses in radiology and diagnostic nuclear medicine: catalog. Radiology. 2008;248:254–263

 Dr. Schoepf is a medical consultant for Bayer-Schering, Wayne, New Jersey, Bracco, Princeton, New Jersey, General Electric, Princeton, New Jersey, Medrad, Indianola, Pennsylvania, Siemens, Malvern, Pennsylvania, and TeraRecon, San Mateo, California and receives research support from Bayer-Schering, Bracco, General Electric, Medrad, and Siemens; Dr. Costello is a medical consultant for Bracco and receives research support from Siemens; and Dr. Zwerner receives research support from Boehringer-Ingelheim, Bristol Myers Squib, Bracco, and Siemens.

 This work was supported in part by the Hounsfield Award of the Society of Computed Body Tomography and Magnetic Resonance (SCBT-MR).

PII: S0002-9149(09)00813-3

doi: 10.1016/j.amjcard.2009.03.051

American Journal of Cardiology
Volume 104, Issue 3 , Pages 318-326 , 1 August 2009