American Journal of Cardiology
Volume 104, Issue 3 , Pages 305-311 , 1 August 2009

Comparison of Frequency of Calcified Versus Non-Calcified Coronary Lesions by Computed Tomographic Angiography in Patients With Stable Versus Unstable Angina Pectoris

  • Matthijs F.L. Meijs, MD

      Affiliations

    • Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    • Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
  • ,
  • W. Bob Meijboom, MD, PhD

      Affiliations

    • Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
    • Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands
  • ,
  • Michiel L. Bots, MD, PhD

      Affiliations

    • Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
  • ,
  • Stamatis Kyrzopoulos, MD

      Affiliations

    • Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
  • ,
  • Rick Neoh Eu, MD

      Affiliations

    • Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
  • ,
  • Mathias Prokop, MD, PhD

      Affiliations

    • Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
  • ,
  • Pieter A. Doevendans, MD, PhD

      Affiliations

    • Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
  • ,
  • Pim J. de Feyter, MD, PhD

      Affiliations

    • Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
    • Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands
  • ,
  • Maarten J. Cramer, MD, PhD

      Affiliations

    • Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    • Corresponding Author InformationCorresponding author: Tel: 31-88-7555555; fax: 31-30-2505479

Received 24 February 2009 ,Revised 23 March 2009 ,Accepted 23 March 2009.

References 

  1. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (1). N Engl J Med. 1992;326:242–250
  2. Pasterkamp G, Schoneveld AH, van der Wal AC, Haudenschild CC, Clarijs RJ, Becker AE, et al. Relation of arterial geometry to luminal narrowing and histologic markers for plaque vulnerability: the remodeling paradox. J Am Coll Cardiol. 1998;32:655–662
  3. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801–809
  4. Schoenhagen P, Ziada KM, Kapadia SR, Crowe TD, Nissen SE, Tuzcu EM. Extent and direction of arterial remodeling in stable versus unstable coronary syndromes: an intravascular ultrasound study. Circulation. 2000;101:598–603
  5. Achenbach S, Moselewski F, Ropers D, Ferencik M, Hoffmann U, MacNeill B, et al. Detection of calcified and noncalcified coronary atherosclerotic plaque by contrast-enhanced, submillimeter multidetector spiral computed tomography: a segment-based comparison with intravascular ultrasound. Circulation. 2004;109:14–17
  6. Leber AW, Knez A, Becker A, Becker C, von ZF, Nikolaou K, et al. Accuracy of multidetector spiral computed tomography in identifying and differentiating the composition of coronary atherosclerotic plaques: a comparative study with intracoronary ultrasound. J Am Coll Cardiol. 2004;43:1241–1247
  7. Schroeder S, Kopp AF, Baumbach A, Meisner C, Kuettner A, Georg C, et al. Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography. J Am Coll Cardiol. 2001;37:1430–1435
  8. Achenbach S, Ropers D, Hoffmann U, MacNeill B, Baum U, Pohle K, et al. Assessment of coronary remodeling in stenotic and nonstenotic coronary atherosclerotic lesions by multidetector spiral computed tomography. J Am Coll Cardiol. 2004;43:842–847
  9. Hoffmann U, Moselewski F, Nieman K, Jang IK, Ferencik M, Rahman AM, et al. Noninvasive assessment of plaque morphology and composition in culprit and stable lesions in acute coronary syndrome and stable lesions in stable angina by multidetector computed tomography. J Am Coll Cardiol. 2006;47:1655–1662
  10. Imazeki T, Sato Y, Inoue F, Anazawa T, Tani S, Matsumoto N, et al. Evaluation of coronary artery remodeling in patients with acute coronary syndrome and stable angina by multislice computed tomography. Circ J. 2004;68:1045–1050
  11. Motoyama S, Kondo T, Sarai M, Sugiura A, Harigaya H, Sato T, et al. Multislice computed tomographic characteristics of coronary lesions in acute coronary syndromes. J Am Coll Cardiol. 2007;50:319–326
  12. Pundziute G, Schuijf JD, Jukema JW, Decramer I, Sarno G, Vanhoenacker PK, et al. Evaluation of plaque characteristics in acute coronary syndromes: non-invasive assessment with multi-slice computed tomography and invasive evaluation with intravascular ultrasound radiofrequency data analysis. Eur Heart J. 2008;29:2373–2381
  13. Meijboom WB, Meijs MF, Schuijf JD, Cramer MJ, Mollet NR, van Mieghem CA, et al. Diagnostic accuracy of 64-slice computed tomography coronary angiography a prospective, multicenter, multivendor study. J Am Coll Cardiol. 2008;52:2135–2144
  14. Leber AW, Knez A, von ZF, Becker A, Nikolaou K, Paul S, et al. Quantification of obstructive and nonobstructive coronary lesions by 64-slice computed tomography: a comparative study with quantitative coronary angiography and intravascular ultrasound. J Am Coll Cardiol. 2005;46:147–154
  15. Ehara S, Kobayashi Y, Yoshiyama M, Shimada K, Shimada Y, Fukuda D, et al. Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction: an intravascular ultrasound study. Circulation. 2004;110:3424–3429
  16. Cademartiri F, Mollet NR, Runza G, Bruining N, Hamers R, Somers P, et al. Influence of intracoronary attenuation on coronary plaque measurements using multislice computed tomography: observations in an ex vivo model of coronary computed tomography angiography. Eur Radiol. 2005;15:1426–1431
  17. Budoff MJ, Diamond GA, Raggi P, Arad Y, Guerci AD, Callister TQ, et al. Continuous probabilistic prediction of angiographically significant coronary artery disease using electron beam tomography. Circulation. 2002;105:1791–1796
  18. Garcia MJ, Lessick J, Hoffmann MH. Accuracy of 16-row multidetector computed tomography for the assessment of coronary artery stenosis. JAMA. 2006;296:403–411
  19. Miller JM, Rochitte CE, Dewey M, rbab-Zadeh A, Niinuma H, Gottlieb I, et al. Diagnostic performance of coronary angiography by 64-row CT. N Engl J Med. 2008;359:2324–2336
  20. Mollet NR, Cademartiri F, van Mieghem CA, Runza G, McFadden EP, Baks T, et al. High-resolution spiral computed tomography coronary angiography in patients referred for diagnostic conventional coronary angiography. Circulation. 2005;112:2318–2323
  21. Schroeder S, Achenbach S, Bengel F, Burgstahler C, Cademartiri F, de FP, et al. Cardiac computed tomography: indications, applications, limitations, and training requirements: report of a Writing Group deployed by the Working Group Nuclear Cardiology and Cardiac CT of the European Society of Cardiology and the European Council of Nuclear Cardiology. Eur Heart J. 2008;29:531–556
  22. Johnson TR, Krauss B, Sedlmair M, Grasruck M, Bruder H, Morhard D, et al. Material differentiation by dual energy CT: initial experience. Eur Radiol. 2007;17:1510–1517

 This study was funded by an investigational grant 945-04-263 from ZonMw (The Hague, The Netherlands). Dr. Kyrzopoulos is supported by an educational grant from the Hellenic Cardiological Society, Athens, Greece.

PII: S0002-9149(09)00811-X

doi: 10.1016/j.amjcard.2009.03.049

American Journal of Cardiology
Volume 104, Issue 3 , Pages 305-311 , 1 August 2009