American Journal of Cardiology
Volume 104, Issue 2 , Pages 158-163 , 15 July 2009

Sudden Cardiac Death in Patients With Silent Myocardial Ischemia After Myocardial Infarction (from the Swiss Interventional Study on Silent Ischemia Type II [SWISSI II])

  • Andreas Wolfgang Schoenenberger, MD

      Affiliations

    • Department of Geriatrics and Department of General Internal Medicine, University of Bern Hospital Inselspital Bern, Switzerland
    • Institute of Social and Preventive Medicine, University of Berne, Switzerland
  • ,
  • Richard Kobza, MD

      Affiliations

    • Department of Cardiology, Luzerner Kantonsspital, Lucerne, Switzerland
  • ,
  • Peiman Jamshidi, MD

      Affiliations

    • Department of Cardiology, Luzerner Kantonsspital, Lucerne, Switzerland
  • ,
  • Michel Zuber, MD

      Affiliations

    • Department of Cardiology, Luzerner Kantonsspital, Lucerne, Switzerland
  • ,
  • Antonio Abbate, MD

      Affiliations

    • Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia
  • ,
  • Andreas Ernst Stuck, MD

      Affiliations

    • Department of Geriatrics and Department of General Internal Medicine, University of Bern Hospital Inselspital Bern, Switzerland
    • Institute of Social and Preventive Medicine, University of Berne, Switzerland
  • ,
  • Matthias Pfisterer, MD

      Affiliations

    • Department of Cardiology, University Hospital, Basel, Switzerland
  • ,
  • Paul Erne, MD

      Affiliations

    • Department of Cardiology, Luzerner Kantonsspital, Lucerne, Switzerland
    • Corresponding Author InformationCorresponding author: Tel: +41-41-2055208; fax: +41-41-2055109

Received 12 January 2009 ,Revised 8 March 2009 ,Accepted 8 March 2009.

References 

  1. Conti CR. Silent cardiac ischemia. Curr Opin Cardiol. 2002;17:537–542
  2. Cohn PF. Silent myocardial ischemia: recent developments. Curr Atheroscler Rep. 2005;7:155–163
  3. Cohn PF, Fox KM, Daly C. Silent myocardial ischemia. Circulation. 2003;108:1263–1277
  4. Thaulow E, Erikssen J, Sandvik L, Erikssen G, Jorgensen L, Cohn PF. Initial clinical presentation of cardiac disease in asymptomatic men with silent myocardial ischemia and angiographically documented coronary artery disease (the Oslo Ischemia Study). Am J Cardiol. 1993;72:629–633
  5. Erne P, Schoenenberger AW, Zuber M, Burckhardt D, Kiowski W, Dubach P, et al. Effects of anti-ischemic drug therapy in silent myocardial ischemia type I—the Swiss Interventional Study on Silent Ischemia Type I (SWISSI I): a randomized, controlled pilot study. Eur Heart J. 2007;28:2110–2117
  6. Erne P, Schoenenberger AW, Burckhardt D, Zuber M, Kiowski W, Buser PT, et al. Effects of percutaneous coronary interventions in silent ischemia after myocardial infarction: the SWISSI II randomized controlled trial. JAMA. 2007;297:1985–1991
  7. Sheps DS, Heiss G. Sudden death and silent myocardial ischemia. Am Heart J. 1989;117:177–184
  8. Pedone C, Elhendy A, Biagini E, van Domburg RT, Schinkel AF, Di PG, et al. Prognostic significance of myocardial ischemia by dobutamine stress echocardiography in patients without angina pectoris after coronary revascularization. Am J Cardiol. 2008;102:1156–1158
  9. Aronow WS, Ahn C, Mercando AD, Epstein S, Kronzon I. Prevalence of and association between silent myocardial ischemia and new coronary events in older men and women with and without cardiovascular disease. J Am Geriatr Soc. 2002;50:1075–1078
  10. Lotze U, Ozbek C, Gerk U, Kaufmann H, Sen S, Figulla HR. Three-year follow-up of patients with silent ischemia in the subacute phase of myocardial infarction after thrombolysis and early coronary intervention. Int J Cardiol. 1999;71:167–178
  11. Myerburg RJ, Kessler KM, Mallon SM, Cox MM, de Marchena E, Interian A, et al. Life-threatening ventricular arrhythmias in patients with silent myocardial ischemia due to coronary-artery spasm. N Engl J Med. 1992;326:1451–1455
  12. Hinkle LE, Thaler HT. Clinical classification of cardiac deaths. Circulation. 1982;65:457–464
  13. Myerburg RJ, Kessler KM, Castellanos A. Sudden cardiac death: epidemiology, transient risk, and intervention assessment. Ann Intern Med. 1993;119:1187–1197
  14. Goldberger JJ, Cain ME, Hohnloser SH, Kadish AH, Knight BP, Lauer MS, et al. American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society scientific statement on noninvasive risk stratification techniques for identifying patients at risk for sudden cardiac death: a scientific statement from the American Heart Association Council on Clinical Cardiology Committee on Electrocardiography and Arrhythmias and Council on Epidemiology and Prevention. Heart Rhythm. 2008;5:e1–e21
  15. Priori SG, Aliot E, Blomstrom-Lundqvist C, Bossaert L, Breithardt G, Brugada P, et al. Task Force on Sudden Cardiac Death of the European Society of Cardiology. Eur Heart J. 2001;22:1374–1450
  16. Moss AJ, Hall WJ, Cannom DS, Daubert JP, Higgins SL, Klein H, et al. Improved survival with an implantable defibrillator in patients with coronary artery disease at high risk for ventricular arrhythmia. N Engl J Med. 1996;335:1933–1940
  17. Moss AJ, Zareba W, Hall WJ, Klein H, Wilber DJ, Cannom DS, et al. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med. 2002;346:877–883
  18. Bigger JT, Fleiss JL, Kleiger R, Miller JP, Rolnitzky LM. The relationships among ventricular arrhythmias, left ventricular dysfunction, and mortality in the 2 years after myocardial infarction. Circulation. 1984;69:250–258
  19. Mäkikallio TH, Barthel P, Schneider R, Bauer A, Tapanainen JM, Tulppo MP, et al. Frequency of sudden cardiac death among acute myocardial infarction survivors with optimized medical and revascularization therapy. Am J Cardiol. 2006;97:480–484
  20. Ruta J, Bolińska H, Ptaszyński P, Rosiak M, Wranicz KJ, Kośmider M, et al. The impact of very late revascularization of occluded infarct-related artery on cardiac mortality and the incidence of sudden death in survivors of acute myocardial infarction—long-term observation. Med Sci Monit. 2002;8:364–370
  21. Schoenenberger AW, Erne P, Ammann S, Gillmann G, Kobza R, Stuck AE. Prediction of arrhythmic events after myocardial infarction based on signal-averaged electrocardiogram and ejection fraction. Pacing Clin Electrophysiol. 2008;31:221–228
  22. Abbate A, Biondi-Zoccai GG, Appleton DL, Erne P, Schoenenberger AW, Lipinski MJ, et al. Survival and cardiac remodeling benefits in patients undergoing late percutaneous coronary intervention of the infarct-related artery: evidence from a meta-analysis of randomized controlled trials. J Am Coll Cardiol. 2008;51:956–964
  23. Abbate A, Bussani R, Biondi-Zoccai GG, Santini D, Petrolini A, De Giorgio F, et al. Infarct-related artery occlusion, tissue markers of ischaemia, and increased apoptosis in the peri-infarct viable myocardium. Eur Heart J. 2005;26:2039–2045
  24. Buxton AE, Lee KL, Hafley GE, Pires LA, Fisher JD, Gold MR, et al. Limitations of ejection fraction for prediction of sudden death risk in patients with coronary artery disease: lessons from the MUSTT study. J Am Coll Cardiol. 2007;50:1150–1157
  25. Hochman JS, Lamas GA, Buller CE, Dzavik V, Reynolds HR, Abramsky SJ, et al. Coronary intervention for persistent occlusion after myocardial infarction. N Engl J Med. 2006;355:2395–2407

 The Swiss Interventional Study on Silent Ischemia Type II was funded by a grant from the von Muralt Stiftung/Swiss Heart Foundation, Berne, Switzerland, and supported by unrestricted grants from Hoechst Pharma, Merck Pharma, and Pfizer, all in Switzerland. Andreas Schoenenberger, MD, was supported by a Forschungskolleg Geriatrie Grant from the Robert Bosch Foundation, Stuttgart, Germany. None of the granting institutions had any influence on the study design, data collection, analysis and interpretation. All authors have disclosed all associations (either commercial or industrial) that might pose a conflict of interest.

PII: S0002-9149(09)00723-1

doi: 10.1016/j.amjcard.2009.03.019

American Journal of Cardiology
Volume 104, Issue 2 , Pages 158-163 , 15 July 2009