American Journal of Cardiology
Volume 103, Issue 12 , Pages 1727-1731, 15 June 2009

Serum C-Reactive Protein and Risk of Cardiovascular Events in Middle-Aged and Older Chinese Population

  • Shan Jiang, MM

      Affiliations

    • Department of Endocrinology and Metabolism, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, China
    • ,
  • Yuqian Bao, MD

      Affiliations

    • Department of Endocrinology and Metabolism, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, China
    • ,
  • Xuhong Hou, MS

      Affiliations

    • Department of Endocrinology and Metabolism, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, China
    • ,
  • Qichen Fang, PhD

      Affiliations

    • Department of Endocrinology and Metabolism, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, China
    • ,
  • Chen Wang, PhD, MD

      Affiliations

    • Department of Endocrinology and Metabolism, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, China
    • ,
  • Jiemin Pan, MD

      Affiliations

    • Department of Endocrinology and Metabolism, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, China
    • ,
  • Yuhua Zuo, MD

      Affiliations

    • Caoyang Health Center, Shanghai, China
    • ,
  • Wenhong Zhong, MD

      Affiliations

    • Huayang Health Center, Shanghai, China
    • ,
  • Kunsan Xiang, MD

      Affiliations

    • Department of Endocrinology and Metabolism, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, China
    • ,
  • Weiping Jia, MD, PhD

      Affiliations

    • Department of Endocrinology and Metabolism, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, China
    • Corresponding Author InformationCorresponding author: Tel: 8621-6436-9181-8922; fax: 8621-6436-8031

Received 18 November 2008; received in revised form 10 February 2009; accepted 10 February 2009. published online 20 April 2009.

The purpose of the present study was to investigate the effect of high-sensitivity C-reactive protein (hs-CRP) on the risk of cardiovascular disease (CVD) in a Chinese population. A total of 2,656 participants (aged 30 to 95 years) with baseline hs-CRP levels available were monitored for the incidence of a composite of CVD events (stroke and coronary heart disease) during a 5.5-year period. With increasing quartiles of hs-CRP (<0.47, 0.47 to 0.97, 0.97 to 2.09, and ≥2.09 mg/L), the incidence of CVD increased progressively (11.7, 16.4, 24.7, and 36.5 per 1,000 person-years, respectively). In a Cox model adjusted for other traditional risk factors (e.g., age, blood pressure, diabetes mellitus, lipids, body mass index, smoking status), elevated hs-CRP (≥2.0 mg/L) independently predicted the risk of CVD (hazard ratio 1.39; 95% confidence interval 1.04 to 1.87). The effect was especially significant for stroke (hazard ratio 1.58; confidence interval 1.08 to 2.31). In conclusion, the results of our study suggest that elevated hs-CRP (≥2.0 mg/L) is an effective predictor of CVD in a Chinese population.

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 This work was supported by the Key Project from Science and Technology Commission of Shanghai Municipality, Shanghai, China, Grant 04DZ19501; Scientific Research Program of Shanghai Municipal Education Commission, Shanghai, China, Grant 06BZ061; and National Basic Research Program of China (973 Program), The Ministry of Science and Technology of the People's Republic of China, Beijing, China, Grant 2006CB503901.

PII: S0002-9149(09)00609-2

doi:10.1016/j.amjcard.2009.02.028

American Journal of Cardiology
Volume 103, Issue 12 , Pages 1727-1731, 15 June 2009

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