American Journal of Cardiology
Volume 103, Issue 12 , Pages 1721-1726 , 15 June 2009

Effect of Caloric Restriction on Myocardial Fatty Acid Uptake, Left Ventricular Mass, and Cardiac Work in Obese Adults

  • Antti P.M. Viljanen, MD

      Affiliations

    • Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    • Corresponding Author InformationCorresponding author: Tel: 358-2-313-0000; fax: 358-2-231-8191
  • ,
  • Anna Karmi, BM

      Affiliations

    • Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
  • ,
  • Ronald Borra, MD

      Affiliations

    • Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
  • ,
  • Jussi P. Pärkkä, MD

      Affiliations

    • Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland
  • ,
  • Virva Lepomäki, MSc

      Affiliations

    • Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
  • ,
  • Riitta Parkkola, MD, PhD

      Affiliations

    • Department of Radiology, University of Turku and Turku University Hospital, Turku, Finland
  • ,
  • Riikka Lautamäki, MD, PhD

      Affiliations

    • Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
  • ,
  • Mikko Järvisalo, MD, PhD

      Affiliations

    • Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
  • ,
  • Markku Taittonen, MD, PhD

      Affiliations

    • Department of Anesthesiology, University of Turku and Turku University Hospital, Turku, Finland
  • ,
  • Tapani Rönnemaa, MD, PhD, Prof

      Affiliations

    • Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland
  • ,
  • Patricia Iozzo, MD, PhD

      Affiliations

    • Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    • PET Centre, Institute of Clinical Physiology, National Research Council, Pisa, Italy
  • ,
  • Juhani Knuuti, MD, PhD, Prof

      Affiliations

    • Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
  • ,
  • Pirjo Nuutila, MD, PhD, Prof

      Affiliations

    • Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    • Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland
  • ,
  • Olli T. Raitakari, MD, PhD, Prof

      Affiliations

    • Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland

Received 13 January 2009 ,Revised 10 February 2009 ,Accepted 10 February 2009.

References 

  1. Mazumder PK, O'Neill BT, Roberts MW, Buchanan J, Yun UJ, Cooksey RC, et al. Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts. Diabetes. 2004;53:2366–2374
  2. Aasum E, Hafstad AD, Severson DL, Larsen TS. Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice. Diabetes. 2003;52:434–441
  3. Unger RH. Lipotoxic diseases. Annu Rev Med. 2002;53:319–336
  4. Zhou YT, Grayburn P, Karim A, Shimabukuro M, Higa M, Baetens D, et al. Lipotoxic heart disease in obese rats: implications for human obesity. Proc Natl Acad Sci U S A. 2000;97:1784–1789
  5. Carroll JF, Tyagi SC. Extracellular matrix remodeling in the heart of the homocysteinemic obese rabbit. Am J Hypertens. 2005;18:692–698
  6. Kankaanpää M, Lehto HR, Pärkkä JP, Komu M, Viljanen A, Ferrannini E, et al. Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels. J Clin Endocrinol Metab. 2006;91:4689–4695
  7. Peterson LR, Herrero P, Schechtman KB, Racette SB, Waggoner AD, Kisrieva-Ware Z, et al Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women. Circulation. 2004;109:2191–2196
  8. Hammer S, Snel M, Lamb HJ, Jazet IM, van der Meer RW, Pijl H, et al. Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function. J Am Coll Cardiol. 2008;52:1006–1012
  9. Mäki M, Nuutila P, Laine H, Voipio-Pulkki LM, Haaparanta M, Solin O, et al. Myocardial glucose uptake in patients with NIDDM and stable coronary artery disease. Diabetes. 1997;46:1491–1496
  10. Laine H, Raitakari OT, Niinikoski H, Pitkanen OP, Iida H, Viikari J, et al. Early impairment of coronary flow reserve in young men with borderline hypertension. J Am Coll Cardiol. 1998;32:147–153
  11. Mäki MT, Haaparanta M, Nuutila P, Oikonen V, Luotolahti M, Eskola O, et al. Free fatty acid uptake in the myocardium and skeletal muscle using fluorine-18-fluoro-6-thia-heptadecanoic acid. J Nucl Med. 1998;39:1320–1327
  12. Stolen KQ, Kemppainen J, Kalliokoski KK, Luotolahti M, Viljanen T, Nuutila P, et al. Exercise training improves insulin-stimulated myocardial glucose uptake in patients with dilated cardiomyopathy. J Nucl Cardiol. 2003;10:447–455
  13. Takala TO, Nuutila P, Pulkki K, Oikonen V, Grönroos T, Savunen T, et al 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid as a tracer of free fatty acid uptake and oxidation in myocardium and skeletal muscle. Eur J Nucl Med Mol Imaging. 2002;29:1617–1622
  14. Viljanen AP, Lautamäki R, Järvisalo M, Parkkola R, Huupponen R, Lehtimäki T, et al. Effects of weight loss on visceral and abdominal subcutaneous adipose tissue blood-flow and insulin-mediated glucose uptake in healthy obese subjects. Ann Med. 2008;14:1–9
  15. Viljanen AP, Iozzo P, Borra R, Kankaanpää M, Karmi A, Lautamäki R, et al Effect of weight loss on liver free fatty acid uptake and hepatic insulin resistance. J Clin Endocrinol Metab. 2009;94:50–55
  16. Iida H, Takahashi A, Tamura Y, Ono Y, Lammertsma AA. Myocardial blood flow: comparison of oxygen-15-water bolus injection, slow infusion and oxygen-15-carbon dioxide slow inhalation. J Nucl Med. 1995;36:78–85
  17. Iida H, Rhodes CG, de Silva R, Araujo LI, Bloomfield PM, Lammertsma AA, et al. Use of the left ventricular time-activity curve as a noninvasive input function in dynamic oxygen-15-water positron emission tomography. J Nucl Med. 1992;33:1669–1677
  18. Sokoloff L, Reivich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettigrew KD, et al. The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem. 1977;28:897–916
  19. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med. 1993;30:672–679
  20. Szczepaniak LS, Babcock EE, Schick F, Dobbins RL, Garg A, Burns DK, et al. Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am J Physiol. 1999;276:E977–E989
  21. Thomsen C, Becker U, Winkler K, Christoffersen P, Jensen M, Henriksen O. Quantification of liver fat using magnetic resonance spectroscopy. Magn Reson Imaging. 1994;12:487–495
  22. Alfakih K, Reid S, Jones T, Sivananthan M. Assessment of ventricular function and mass by cardiac magnetic resonance imaging. Eur Radiol. 2004;14:1813–1822
  23. Leichman JG, Aguilar D, King TM, Vlada A, Reyes M, Taegtmeyer H. Association of plasma free fatty acids and left ventricular diastolic function in patients with clinically severe obesity. Am J Clin Nutr. 2006;84:336–341
  24. Borradaile NM, Schaffer JE. Lipotoxicity in the heart. Curr Hypertens Rep. 2005;7:412–417
  25. Christoffersen C, Bollano E, Lindegaard ML, Bartels ED, Goetze JP, Andersen CB, et al. Cardiac lipid accumulation associated with diastolic dysfunction in obese mice. Endocrinology. 2003;144:3483–3490
  26. Ouwens DM, Boer C, Fodor M, de Galan P, Heine RJ, Maassen JA, et al. Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signaling in rats. Diabetologia. 2005;48:1229–1237
  27. Opie LH. The Heart. 3rd ed.. Philadelphia, Pennsylvania: Lippincott-Raven; 1998;
  28. Nuutila P, Koivisto VA, Knuuti J, Ruotsalainen U, Teras M, Haaparanta M, et al. Glucose-free fatty acid cycle operates in human heart and skeletal muscle in vivo. J Clin Invest. 1992;89:1767–1774
  29. Knuuti MJ, Maki M, Yki-Jarvinen H, Voipio-Pulkki LM, Harkonen R, Haaparanta M, et al. The effect of insulin and FFA on myocardial glucose uptake. J Mol Cell Cardiol. 1995;27:1359–1367

 This work was supported by grants and funding from the HEPADIP EU FP6 program, Copenhagen University Hospital, Copenhagen, Denmark, the Novo Nordisk Foundation, Gentofte, Denmark, the Yrjö Jahnsson Foundation, Helsinki, Finland, the Juho Vainio Foundation, Helsinki, Finland, the Finnish Diabetes Foundation, Helsinki, Finland, the Orion Group Research Foundation, Helsinki, Finland, the Aarne Koskelo Foundation, Espoo, Finland, the Finnish Medical Society Duodecim, Helsinki, Finland, the EFSD/Eli-Lilly fellowship in diabetes and metabolism, Düsseldorf, Germany, and the Hospital District of Southwest Finland, Turku, Finland. The study was conducted within the Centre of Excellence in Molecular Imaging in Cardiovascular and Metabolic Research, supported by the Academy of Finland, Helsinki, Finland, University of Turku, Helsinki, Finland, Turku University Hospital, Helsinki, Finland, and Abo Academy, Helsinki, Finland.

PII: S0002-9149(09)00606-7

doi: 10.1016/j.amjcard.2009.02.025

American Journal of Cardiology
Volume 103, Issue 12 , Pages 1721-1726 , 15 June 2009