American Journal of Cardiology
Volume 103, Issue 12 , Pages 1710-1715 , 15 June 2009

Eligibility of Individuals With Subclinical Coronary Artery Calcium and Intermediate Coronary Heart Disease Risk for Reclassification (from the Framingham Heart Study)

  • Sarah Rosner Preis, ScD, MPH

      Affiliations

    • Center for Population Studies, National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts
    • ,
  • Shih-Jen Hwang, PhD

      Affiliations

    • Center for Population Studies, National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts
    • ,
  • Caroline S. Fox, MD, MPH

      Affiliations

    • Center for Population Studies, National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts
    • Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • ,
  • Joseph M. Massaro, PhD

      Affiliations

    • Department of Mathematics, Boston University, Boston, Massachusetts
    • ,
  • Daniel Levy, MD

      Affiliations

    • Center for Population Studies, National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts
    • ,
  • Udo Hoffmann, MD, MPH

      Affiliations

    • MGH Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
    • ,
  • Christopher J. O'Donnell, MD, MPH

      Affiliations

    • Center for Population Studies, National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts
    • Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
    • Corresponding Author InformationCorresponding author: Tel: 508-935-3435; fax: 508-626-1262

Received 17 December 2008 ,Revised 15 February 2009 ,Accepted 15 February 2009.

References 

  1. Dawber TR, Kannel WB, Lyell LP. An approach to longitudinal studies in a community: the Framingham Study. Ann N Y Acad Sci. 1963;107:539–556
  2. Feinleib M, Kannel WB, Garrison RJ, McNamara PM, Castelli WP. The Framingham Offspring Study (Design and preliminary data). Prev Med. 1975;4:518–525
  3. Splansky GL, Corey D, Yang Q, Atwood LD, Cupples LA, Benjamin EJ, et al The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination. Am J Epidemiol. 2007;165:1328–1335
  4. Hong C, Bae KT, Pilgram TK. Coronary artery calcium: accuracy and reproducibility of measurements with multi-detector row CT—assessment of effects of different thresholds and quantification methods. Radiology. 2003;227:795–801
  5. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15:827–832
  6. Callister TQ, Cooil B, Raya SP, Lippolis NJ, Russo DJ, Raggi P. Coronary artery disease: improved reproducibility of calcium scoring with an electron-beam CT volumetric method. Radiology. 1998;208:807–814
  7. Hoffmann U, Massaro JM, Fox CS, Manders ES, O'Donnell CJ. Defining normal distributions of coronary artery calcification in at-risk community-based women and men: the Framingham Heart Study. Colorado Springs, CO: American Heart Association, 8 A.D.
  8. Hoff JA, Chomka EV, Krainik AJ, Daviglus M, Rich S, Kondos GT. Age and gender distributions of coronary artery calcium detected by electron beam tomography in 35,246 adults. Am J Cardiol. 2001;87:1335–1339
  9. McClelland RL, Chung H, Detrano R, Post W, Kronmal RA. Distribution of coronary artery calcium by race, gender, and age: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation. 2006;113:30–37
  10. Greenland P, Bonow RO, Brundage BH, Budoff MJ, Eisenberg MJ, Grundy SM, et al ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF/AHA writing committee to update the 2000 expert consensus document on electron beam computed tomography) developed in collaboration with the Society of Atherosclerosis Imaging and Prevention and the Society of Cardiovascular Computed Tomography. J Am Coll Cardiol. 2007;49:378–402
  11. Budoff MJ, Achenbach S, Blumenthal RS, Carr JJ, Goldin JG, Greenland P, et al. Assessment of coronary artery disease by cardiac computed tomography: a scientific statement from the American Heart Association Committee on Cardiovascular Imaging and Intervention, Council on Cardiovascular Radiology and Intervention, and Committee on Cardiac Imaging, Council on Clinical Cardiology. Circulation. 2006;114:1761–1791
  12. Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;285:2486–2497
  13. Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97:1837–1847
  14. Wilson PW, Smith SC, Blumenthal RS, Burke GL, Wong ND. 34th Bethesda Conference: task force #4—how do we select patients for atherosclerosis imaging?. J Am Coll Cardiol. 2003;41:1898–1906
  15. Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, et al Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med. 2008;358:1336–1345
  16. Taylor AJ, Bindeman J, Feuerstein I, Le T, Bauer K, Byrd C, et al. Community-based provision of statin and aspirin after the detection of coronary artery calcium within a community-based screening cohort. J Am Coll Cardiol. 2008;51:1337–1341
  17. Shaw LJ, Raggi P, Berman DS, Callister TQ. Coronary artery calcium as a measure of biologic age. Atherosclerosis. 2006;188:112–119
  18. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al. The Seventh Report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA. 2003;289:2560–2572
  19. Arad Y, Goodman KJ, Roth M, Newstein D, Guerci AD. Coronary calcification, coronary disease risk factors, C-reactive protein, and atherosclerotic cardiovascular disease events: the St. Francis Heart Study. J Am Coll Cardiol. 2005;46:158–165
  20. Greenland P, LaBree L, Azen SP, Doherty TM, Detrano RC. Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals. JAMA. 2004;291:210–215
  21. Kondos GT, Hoff JA, Sevrukov A, Daviglus ML, Garside DB, Devries SS, et al. Electron-beam tomography coronary artery calcium and cardiac events: a 37-month follow-up of 5635 initially asymptomatic low- to intermediate-risk adults. Circulation. 2003;107:2571–2576
  22. LaMonte MJ, FitzGerald SJ, Church TS, Barlow CE, Radford NB, Levine BD, et al. Coronary artery calcium score and coronary heart disease events in a large cohort of asymptomatic men and women. Am J Epidemiol. 2005;162:421–429
  23. Raggi P, Cooil B, Callister TQ. Use of electron beam tomography data to develop models for prediction of hard coronary events. Am Heart J. 2001;141:375–382
  24. Taylor AJ, Bindeman J, Feuerstein I, Cao F, Brazaitis M, O'Malley PG. Coronary calcium independently predicts incident premature coronary heart disease over measured cardiovascular risk factors: mean three-year outcomes in the Prospective Army Coronary Calcium (PACC) project. J Am Coll Cardiol. 2005;46:807–814
  25. Wong ND, Hsu JC, Detrano RC, Diamond G, Eisenberg H, Gardin JM. Coronary artery calcium evaluation by electron beam computed tomography and its relation to new cardiovascular events. Am J Cardiol. 2000;86:495–498
  26. Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, et al Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008;359:2195–2207
  27. Kaplan NM, Sproul LE, Mulcahy WS. Large prospective study of ramipril in patients with hypertension (CARE Investigators). Clin Ther. 1993;15:810–818
  28. Dagenais GR, Yusuf S, Bourassa MG, Yi Q, Bosch J, Lonn EM, et al. Effects of ramipril on coronary events in high-risk persons: results of the Heart Outcomes Prevention Evaluation Study. Circulation. 2001;104:522–526

 This work was supported by the National Heart, Lung, and Blood Institute's Framingham Heart Study (Contract No. N01-HC-25195), Framingham, Massachusetts.

PII: S0002-9149(09)00602-X

doi: 10.1016/j.amjcard.2009.02.020

American Journal of Cardiology
Volume 103, Issue 12 , Pages 1710-1715 , 15 June 2009

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