American Journal of Cardiology
Volume 103, Issue 12 , Pages 1641-1646 , 15 June 2009

Predictive Value of Heart Rate Recovery and Peak Oxygen Consumption for Long-Term Mortality in Patients With Coronary Heart Disease

  • Bilal Aijaz, MD

      Affiliations

    • Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota
    • Corresponding Author InformationCorresponding author: Tel: (507) 284-0592; fax: (507) 284-5370
  • ,
  • Ray W. Squires, PhD

      Affiliations

    • Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota
  • ,
  • Randal J. Thomas, MD

      Affiliations

    • Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota
  • ,
  • Bruce D. Johnson, PhD

      Affiliations

    • Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota
  • ,
  • Thomas G. Allison, PhD

      Affiliations

    • Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota

Received 12 December 2008 ,Accepted 10 February 2009.

References 

  1. Laukkanen JA, Kurl S, Salonen R, Rauramaa R, Salonen JT. The predictive value of cardiorespiratory fitness for cardiovascular events in men with various risk profiles: a prospective population-based cohort study. Eur Heart J. 2004;25:1428–1437
  2. Kavanagh T, Mertens DJ, Hamm LF, Beyene J, Kennedy J, Corey P, et al. Prediction of long-term prognosis in 12,169 men referred for cardiac rehabilitation. Circulation. 2002;106:666–671
  3. Vanhees L, Fagard R, Thijs L, Staessen J, Amery A. Prognostic significance of peak exercise capacity in patients with coronary artery disease. J Am Coll Cardiol. 1994;23:358–363
  4. Cole CR, Foody JM, Blackstone EH, Lauer MS. Heart rate recovery after submaximal exercise testing as a predictor of mortality in a cardiovascularly healthy cohort. Ann Intern Med. 2000;132:552–555
  5. Cheng YJ, Macera CA, Church TS, Blair SN. Heart rate reserve as a predictor of cardiovascular and all-cause mortality in men. Med Sci Sports Exerc. 2002;34:1873–1878
  6. Cole CR, Blackstone EH, Pashkow FJ, Snader CE, Lauer MS. Heart-rate recovery immediately after exercise as a predictor of mortality. N Engl J Med. 1999;341:1351–1357
  7. Balady GJ, Ades PA, Comoss P, Limacher M, Pina IL, Southard D, et al. Core components of cardiac rehabilitation/secondary prevention programs: a statement for healthcare professionals from the American Heart Association and the American Association of Cardiovascular and Pulmonary Rehabilitation Writing Group. Circulation. 2000;102:1069–1073
  8. Daida H, Allison TG, Squires RW, Miller TD, Gau GT. Peak exercise blood pressure by age and gender in apparently healthy subjects. Mayo Clin Proc. 1996;71:445–452
  9. Kavanagh T, Mertens DJ, Hamm LF, Beyene J, Kennedy J, Corey P, et al. Peak oxygen intake and cardiac mortality in women referred for cardiac rehabilitation. J Am Coll Cardiol. 2003;42:2139–2143
  10. Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002;346:793–801
  11. Morris CK, Ueshima K, Kawaguchi T, Hideg A, Froelicher VF. The prognostic value of exercise capacity: a review of the literature. Am Heart J. 1991;122:1423–1431
  12. Nishime EO, Cole CR, Blackstone EH, Pashkow FJ, Lauer MS. Heart rate recovery and treadmill exercise score as predictors of mortality in patients referred for exercise ECG. J Am Med Assoc. 2000;284:1392–1398
  13. Hagberg J, Blair S, Ehsani A, Gordon N, Kaplan N, Tipton C, et al. Position stand: physical activity, physical fitness, and hypertension. Med Sci Sports Exerc. 1993;25:i–x
  14. Hagberg JM, Ferrell RE, Dengel DR, Wilund KR. Exercise training-induced blood pressure and plasma lipid improvements in hypertensives may be genotype dependent. Hypertension. 1999;34:18–23
  15. Roberts CK, Vaziri ND, Barnard RJ. Effect of diet and exercise intervention on blood pressure, insulin, oxidative stress, and nitric oxide availability. Circulation. 2002;106:2530–2532
  16. Hinderliter A, Sherwood A, Gullette EC, Babyak M, Waugh R, Georgiades A, et al. Reduction of left ventricular hypertrophy after exercise and weight loss in overweight patients with mild hypertension. Arch Intern Med. 2002;162:1333–1339
  17. Costanzo MR, Augustine S, Bourge R, Bristow M, O'Connell JB, Driscoll D, et al. Selection and treatment of candidates for heart transplantation: a statement for health professionals from the Committee on Heart Failure and Cardiac Transplantation of the Council on Clinical Cardiology, American Heart Association. Circulation. 1995;92:3593–3612
  18. Mancini DM, Eisen H, Kussmaul W, Mull R, Edmunds LH, Wilson JR. Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure. Circulation. 1991;83:778–786
  19. Hao SC, Chai A, Kligfield P. Heart rate recovery response to symptom-limited treadmill exercise after cardiac rehabilitation in patients with coronary artery disease with and without recent events. Am J Cardiol. 2002;90:763–765
  20. Hall AS, Palmer S. The heart rate hypothesis: ready to be tested. Heart. 2008;94:561–565
  21. Seals DR, Hagberg JM, Spina RJ, Rogers MA, Schechtman KB, Ehsani AA. Enhanced left ventricular performance in endurance trained older men. Circulation. 1994;89:198–205
  22. La Rovere MT, Bigger JT, Marcus FI, Mortara A, Schwartz PJ ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators. Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. Lancet. 1998;351:478–484
  23. Malfatto G, Facchini M, Sala L, Branzi G, Bragato R, Leonetti G. Relationship between baseline sympatho-vagal balance and the autonomic response to cardiac rehabilitation after a first uncomplicated myocardial infarction. Ital Heart J. 2000;1:226–232
  24. Hirsh DS, Vittorio TJ, Barbarash SL, Hudaihed A, Tseng CH, Arwady A, et al. Association of heart rate recovery and maximum oxygen consumption in patients with chronic congestive heart failure. J Heart Lung Transpl. 2006;25:942–945
  25. Goldsmith RL, Bigger JT, Bloomfield DM, Steinman RC. Physical fitness as a determinant of vagal modulation. Med Sci Sports Exerc. 1997;29:812–817
  26. Jouven X, Empana JP, Schwartz PJ, Desnos M, Courbon D, Ducimetière P. Heart-rate profile during exercise as a predictor of sudden death. N Engl J Med. 2005;352:1951–1958
  27. Lauer MS, Blackstone EH, Young JB, Topol EJ. Cause of death in clinical research: time for a reassessment?. J Am Coll Cardiol. 1999;34:618–620
  28. Aktas MK, Ozduran V, Pothier CE, Lang R, Lauer MS. Global risk scores and exercise testing for predicting all-cause mortality in a preventive medicine program. J Am Med Assoc. 2004;292:1462–1468

PII: S0002-9149(09)00594-3

doi: 10.1016/j.amjcard.2009.02.013

American Journal of Cardiology
Volume 103, Issue 12 , Pages 1641-1646 , 15 June 2009