American Journal of Cardiology
Volume 103, Issue 12 , Pages 1651-1656 , 15 June 2009

Comparison of Neointimal Hyperplasia With Drug-Eluting Stents Versus Bare Metal Stents in Patients Undergoing Intracoronary Bone-Marrow Mononuclear Cell Transplantation Following Acute Myocardial Infarction

  • Adolfo Villa, MD

      Affiliations

    • Department of Cardiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
    • ,
  • Roman Arnold, MD, PhD

      Affiliations

    • Institute of Heart Sciences, Hospital Clínico Universitario, Valladolid, Spain
    • ,
  • Pedro L. Sánchez, MD, PhD

      Affiliations

    • Department of Cardiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
    • ,
  • Federico Gimeno, MD, PhD

      Affiliations

    • Institute of Heart Sciences, Hospital Clínico Universitario, Valladolid, Spain
    • ,
  • Benigno Ramos, MD

      Affiliations

    • Institute of Heart Sciences, Hospital Clínico Universitario, Valladolid, Spain
    • ,
  • Teresa Cantero, MD

      Affiliations

    • Institute of Heart Sciences, Hospital Clínico Universitario, Valladolid, Spain
    • ,
  • Maria Eugenia Fernández, PhD

      Affiliations

    • Instituto de Biología y Genética Molecular, University of Valladolid, Spain
    • ,
  • Ricardo Sanz, MD

      Affiliations

    • Department of Cardiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
    • ,
  • Oliver Gutiérrez, MD

      Affiliations

    • Department of Hematology, Hospital Universitario Río Hortega, Valladolid, Spain
    • ,
  • Pedro Mota, MD

      Affiliations

    • Institute of Heart Sciences, Hospital Clínico Universitario, Valladolid, Spain
    • ,
  • Javier García-Frade, MD, PhD

      Affiliations

    • Department of Hematology, Hospital Universitario Río Hortega, Valladolid, Spain
    • ,
  • José Alberto San Román, MD, PhD

      Affiliations

    • Institute of Heart Sciences, Hospital Clínico Universitario, Valladolid, Spain
    • ,
  • Francisco Fernández-Avilés, MD, PhD

      Affiliations

    • Department of Cardiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
    • Corresponding Author InformationCorresponding author: Tel: 34-914265882; fax: 34-915868276
    • ,
  • TECAM (Terapia Celular Aplicada al Miocardio) Research Group

Received 17 November 2008 ,Revised 5 February 2009 ,Accepted 5 February 2009.

References 

  1. Fernández-Avilés F, San Román JA, García-Frade J, Fernández ME, Peñarrubia MJ, de la Fuente L, et al Experimental and clinical regenerative capability of human bone marrow cells alter myocardial infarction. Circ Res. 2004;95:742–748
  2. Barbato E, Aarnoudse W, Aengevaeren WR, Werner G, Klauss V, Bojara W, et al. Validation of coronary flow reserve measurements by thermodilution in clinical practice. Eur Heart J. 2004;25:219–223
  3. Mintz GS, Nissen SE, Anderson WD, Bailey SR, Erbel R, Fitzgerald PJ, et al. American College of Cardiology clinical expert consensus document on standards on acquisition, measurement and reporting of intravascular ultrasound studies (IVUS): a report of the American College of Cardiology task force on clinical expert consensus documents. J Am Coll Cardiol. 2001;37:1478–1492
  4. Farb A, Weber DK, Kolodgie FD, Burke AP, Virmani R. Morphological predictors of restenosis after coronary stenting in humans. Circulation. 2002;105:2974–2980
  5. Kang HJ, Kim HS, Zhang SY, Park KW, Cho HJ, Koo BK, et al Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomized clinical trial. Lancet. 2004;363:751–756
  6. Bartunek J, Vanderheyden M, Vandekerckhove B, Mansour S, De Bruyne B, De Bondt P, et al. Intracoronary injection of CD133−positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safety. Circulation. 2005;112(suppl):I178–I183
  7. Fukuda D, Sata M, Tanaka K, Nagai R. Potent inhibitory effect of sirolimus on circulating vascular progenitor cells. Circulation. 2005;111:926–931
  8. Nuhrenberg TG, Voisard R, Fahlisch F, Rudelius M, Braun J, Gschwend J, et al Rapamycin attenuates vascular wall inflammation and progenitor cell promoters after angioplasty. FASEB J. 2005;19:246–248
  9. Chen TG, Chen JZ, Wang XX. Effects of Rapamycin on number, activity and eNOS of endothelial progenitor cells from peripheral blood. Cell Prolif. 2006;39:117–125
  10. Imanishi T, Kobayashi K, Kuki S, Takahashi C, Akasaka T. Sirolimus accelerates senescence of endothelial progenitor cells through telomerase inactivation. Atherosclerosis. 2006;189:288–296
  11. Axel DI, Kunert W, Goggelmann C, Oberhoff M, Herdeg C, Kuttner A, et al Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery. Circulation. 1997;96:636–645
  12. Iwahana M, Utoguchi N, Mayumi T, Goryo M, Okada K. Drug resistance and P-glycoprotein expression in endothelial cells of newly formed capillaries induced by tumors. Anticancer Res. 1998;18:2977–2980
  13. Belotti D, Vergani V, Drudis T, Borsotti P, Pitelli MR, Viale G, et al. The microtubule-affecting drug paclitaxel has antiangiogenic activity. Clin Cancer Res. 1996;2:1843–1849
  14. Assmus B, Walter DH, Lehmann R, Honold J, Martin H, Dimmeler S, et al. Intracoronary infusion of progenitor cells is not associated with aggravated restenosis development or atherosclerotic disease progression in patients with acute myocardial infarction. Eur Heart J. 2006;27:2989–2995
  15. Jorgensen E, Ripa RS, Helqvist S, Wang Y, Johnsen HE, Grande P, et al. In-stent neo-intimal hyperplasia after stem cell mobilization by granulocyte-colony stimulating factor (Preliminary intracoronary ultrasound results from a double-blind randomized placebo-controlled study of patients treated with percutaneous coronary intervention for ST-elevation myocardial infarction (STEMMI trial)). Int J Cardiol. 2006;111:174–177
  16. Kang HJ, Kim YS, Koo BK, Park KW, Lee HY, Sohn DW, et al. Effect of stem cell therapy with G-CSF on coronary artery after drug-eluting stent implantation in patients with acute myocardial infarction. Heart. 2008;94:604–609
  17. Cho HJ, Kim TY, Cho HJ, Park KW, Zhang SY, Kim JH, et al The effect of stem cell mobilization by granulocyte-colony stimulating factor on neointimal hyperplasia and endothelial healing after vascular injury with bare-metal versus paclitaxel-eluting stents. J Am Coll Cardiol. 2006;48:366–374

 This work was supported in part by Junta de Castilla y Leon and the networks RECAVA and TERCEL (Instituto de Salud Carlos III, Ministry of Science and Innovation, Spain).

PII: S0002-9149(09)00592-X

doi: 10.1016/j.amjcard.2009.02.011

American Journal of Cardiology
Volume 103, Issue 12 , Pages 1651-1656 , 15 June 2009

Article Tools

* Image Usage & Resolution