American Journal of Cardiology
Volume 103, Issue 11 , Pages 1605-1609 , 1 June 2009

Echocardiographic and Tissue Doppler Imaging of Cardiac Adaptation to High Altitude in Native Highlanders Versus Acclimatized Lowlanders

  • Sandrine Huez, MD

      Affiliations

    • Department of Physiology, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium
    • Department of Cardiology, Erasme University Hospital, Brussels, Belgium
    • ,
  • Vitalie Faoro, PhD

      Affiliations

    • Department of Physiology, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium
    • ,
  • Herve Guénard, MD

      Affiliations

    • Laboratory of Physiology, Faculty Victor Pachon, University of Bordeaux 2, Bordeaux, France
    • ,
  • Jean-Benoit Martinot, MD

      Affiliations

    • Department of Pneumology, St.-Elisabeth-Hospital, Namur, Belgium
    • ,
  • Robert Naeije, MD

      Affiliations

    • Department of Physiology, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium
    • Corresponding Author InformationCorresponding author: Tel: 322-5553322; fax: 322-5554124

Received 4 January 2009 ,Revised 5 February 2009 ,Accepted 5 February 2009.

References 

  1. Rubin LJ, Naeije R. Sildenafil for enhanced performance at high altitude. Ann Intern Med. 2004;141:233–235
  2. Ghofrani HA, Reichenberger F, Kohstall MG, Mrosek EH, Seeger T, Olschewski H, et al. Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial. Ann Intern Med. 2004;141:169–177
  3. West JB. The physiologic basis of high-altitude diseases. Ann Intern Med. 2004;141:789–800
  4. Penaloza D, Arias-Stella J. The heart and pulmonary circulation at high altitudes (Healthy highlanders and chronic mountain sickness). Circulation. 2007;115:1132–1146
  5. Bärtsch P, Gibbs S. Effect of altitude on the heart and the lungs. Circulation. 2007;116:2191–2202
  6. Maggiorini M, Leon-Velarde F. High-altitude pulmonary hypertension: a pathophysiological entity to different diseases. Eur Respir J. 2003;22:1019–1025
  7. Huez S, Faoro V, Vachiéry JL, Unger P, Martinot JB, Naeije R. Images in cardiovascular medicine (High-altitude-induced right-heart failure). Circulation. 2007;115:e308–e309
  8. Huez S, Retailleau K, Unger P, Vachiery JL, Derumeaux G, Naeije R. Right and left ventricular adaptation to hypoxia: a tissue Doppler imaging study. Am J Physiol Heart Circ Physiol. 2005;289:H1391–H1398
  9. Christie J, Sheldahl LM, Tristani FE, Sagar KB, Ptacin MJ, Wann S. Determination of stroke volume and cardiac output during exercise: comparison of two-dimensional and Doppler echocardiography, Fick oximetry, and thermodilution. Circulation. 1987;76:539–547
  10. Yock P, Popp R. Noninvasive estimation of right ventricular systolic pressure by Doppler ultrasound in patients with tricuspid regurgitation. Circulation. 1984;70:657–662
  11. Kitabatake A, Inoue M, Asao M, Masuyama T, Tanouchi J, Morita T, et al Noninvasive evaluation of pulmonary hypertension by a pulsed Doppler technique. Circulation. 1983;68:302–309
  12. Galié N, Hinderlinter A, Torbicki A, Fourme T, Simonneau G, Pulido T, et al Effects of the oral endothelin-receptor antagonist bosentan on echocardiographic and Doppler measures in patients with pulmonary arterial hypertension. J Am Coll Cardiol. 2003;41:1380–1386
  13. Zoghbi WA, Habib GB, Quinones MA. Doppler assessment of right ventricular filling in a normal population (Comparison with left ventricular filling dynamics). Circulation. 1990;82:1316–1324
  14. Ghio S, Recusani F, Klersy C, Sebastiani R, Laudisa ML, Campana C, et al. Prognostic usefulness of tricuspid annular planes systolic excursion in patients with congestive heart failure secondary to idiopathic or ischemic dilated cardiomyopathy. Am J Cardiol. 2000;85:837–842
  15. Tei C, Dujardin K, Hodge D, Bailey KR, McGoon MD, Tajik AJ, et al. Doppler echocardiographic index for assessment of global right ventricular function. J Am Soc Echocardiogr. 1996;9:838–847
  16. Nagueh S, Middleton K, Kopelen H, Zoghbi WA, Quinones MA, Roberts R, et al. Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol. 1997;30:1527–1533
  17. Winer BJ, Brown DR, Michels KM. Statistical Principles in Experimental Design. In: 3rd ed.. New York, New York: McGraw-Hill; 1991;p. 220–283
  18. Hansen J, Sander M. Sympathetic neural overactivity in healthy humans after prolonged exposure to hypobaric hypoxia. J Physiol. 2003;546:921–929
  19. Maignan M, Privat C, Leon-Velarde F, Richalet JP, Pham I. Pulmonary pressure and cardiac function in chronic mountain sickness patients. Chest. 2009;135:499–504

 This work was supported by the Foundation of Cardiac Surgery and by Fonds de la Recherche Scientifique Médicale (Grant 3.4551.05), Brussels, Belgium. Dr. Huez was fellow of Fonds National de la Recherche Scientifique, Brussels, Belgium.

PII: S0002-9149(09)00551-7

doi: 10.1016/j.amjcard.2009.02.006

American Journal of Cardiology
Volume 103, Issue 11 , Pages 1605-1609 , 1 June 2009

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