American Journal of Cardiology
Volume 103, Issue 11 , Pages 1572-1577 , 1 June 2009

Relation of Vigorous Exercise to Risk of Atrial Fibrillation

  • Anthony Aizer, MD, MSc

      Affiliations

    • Center for Arrhythmia Prevention, Brigham and Women's Hospital, Boston, Massachusetts
    • Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts
    • Leon H. Charney Division of Cardiology, Department of Medicine, New York University Medical Center, New York, New York
    • Corresponding Author InformationCorresponding author: Tel: 212-263-5656; fax: 212-263-8534
    • ,
  • J. Michael Gaziano, MD, MPH

      Affiliations

    • Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts
    • Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts
    • Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts
    • Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts
    • ,
  • Nancy R. Cook, ScD

      Affiliations

    • Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts
    • Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
    • ,
  • Joann E. Manson, MD, DrPH

      Affiliations

    • Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts
    • Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
    • ,
  • Julie E. Buring, ScD

      Affiliations

    • Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts
    • Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts
    • Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts
    • Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
    • ,
  • Christine M. Albert, MD, MPH

      Affiliations

    • Center for Arrhythmia Prevention, Brigham and Women's Hospital, Boston, Massachusetts
    • Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts
    • Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts
    • Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts

Received 24 November 2008 ,Revised 31 January 2009 ,Accepted 31 January 2009.

References 

  1. Coelho A, Palileo E, Ashley W, Swiryn S, Petropoulos AT, Welch WJ, et al. Tachyarrhythmias in young athletes. J Am Coll Cardiol. 1986;7:237–243
  2. Hood S, Northcote RJ. Cardiac assessment of veteran endurance athletes: a 12 year follow up study. Br J Sports Med. 1999;33:239–243
  3. Karjalainen J, Kujala UM, Kaprio J, Sarna S, Viitasalo M. Lone AF in vigorously exercising middle aged men: case-control study. BMJ. 1998;316:1784–1785
  4. The Steering Committee of the Physicians' Health Study Research Group. Final report in the aspirin component of the ongoing Physicians' Health Study. N Engl J Med. 1989;321:129–335
  5. Page RL, Tilsch TW, Connolly SJ, Schnell DJ, Marcello SR, Wilkinson WE, et al. Asymptomatic or “silent” atrial fibrillation: frequency in untreated patients and patients receiving azimilide. Circulation. 2003;107:1141–1145
  6. Siconolfi SF, Lasater TM, Snow RCK, Carleton RA. Self-reported physical activity compared with maximal oxygen uptake. Am J Epidemiol. 1985;122:101–105
  7. Kohl HW, Blair SN, Paffenbarger RS, Macera CA, Kronenfeld JJ. A mail survey of physical activity habits as related to measured physical fitness. Am J Epidemiol. 1988;127:1228–1239
  8. Manson JE, Grobbee DE, Stampfer MJ, Taylor JO, Goldhaber SZ, Gaziano JM, et al. Aspirin in the primary prevention of angina pectoris in a randomized trial of United States physicians. Am J Med. 1990;89:772–776
  9. Heidbuchel H, Anne W, Willems R, Adriaenssens B, Van de Werf F, Ector H. Endurance sports is a risk factor for atrial fibrillation after ablation of atrial flutter. Int J Cardiol. 2006;107:67–72
  10. Mont L, Sambola A, Brugada J, Vacca M, Marrugat J, Elosua R, et al. Long-lasting sports practice and lone atrial fibrillation. Eur Heart J. 2002;23:477–482
  11. Mont L, Tamborero D, Elosua R, Molina I, Coll-Vincent B, Sitges M, et al. Physical activity, height, and left atrial size are independent risk factors for lone atrial fibrillation in middle-aged healthy individuals. Europace. 2008;11:15–20
  12. Elosua R, Arquer A, Mont L, Sambola A, Molina L, Garcia-Moran E, et al. Sport practice and the risk of lone atrial fibrillation: a case–control study. Int J Cardiol. 2006;108:332–337
  13. Baldesberger S, Bauersfeld U, Candinas R, Sefiert B, Zuber M, Ritter M, et al Sinus node disease and arrhythmias in the long-term follow-up of former professional cyclists. Eur Heart J. 2008;29:71–78
  14. Northcote R, McKillop G, Todd I, Canning G. The effect of habitual sustained endurance exercise on cardiac structure and function. Eur Heart J. 1990;11:17–22
  15. Kasikcioglu E, Oflaz H, Akhan H, Kayserilioglu A, Umman B, Bugra Z, et al. Left atrial geometric and functional remodeling in athletes. Int J Sports Med. 2006;27:267–271
  16. Pelliccia A, Maron MJ, Di Paolo FM, Biffi A, Quattrini FM, Pisicchio C, et al. Prevalence and clinical significance of left atrial remodeling in competitive athletes. J Am Coll Cardiol. 2005;46:690–696
  17. Kannel WB, Wolf PA, Benjamin EJ, Levy D. Prevalence, incidence, prognosis and predisposing conditions for atrial fibrillation: population-based estimates. Am J Cardiol. 1998;82(suppl):2N–9N
  18. Jost J, Weiss M, Weicker H. Comparison of sympatho-adrenergic regulation at rest and of the adrenoceptor system in swimmers, long-distance runners, weight lifters, wrestlers and untrained men. Eur J Appl Physiol Occup Physiol. 1989;58:596–604
  19. Talan DA, Bauernfeind RA, Ashley WW, Kanakis C, Rosen KM. Twenty-four hour continuous ECG recordings in long distance runners. Chest. 1982;1:19–24
  20. Huang JL, Wen ZC, Lee WL, Chang MS, Chen SA. Changes in autonomic tone before the onset of paroxysmal atrial fibrillation. Int J Cardiol. 1998;66:275–283
  21. Schuaerte P, Scherlag BJ, Pitha J, Scherlag MA, Reynolds D, Lazzara R, et al. Catheter ablation of cardiac autonomic nerves for the prevention of vagal atrial fibrillation. Circulation. 2000;102:2774–2780
  22. Pappone C, Santinelli V, Manguso F, Vicedomini G, Gugliotta F, Augello G, et al Pulmonary vein denervation enhances long-term benefit after circumferential ablation for paroxysmal atrial fibrillation. Circulation. 2004;109:327–334
  23. Oida E, Kannagi T, Moritani T, Yamori Y. Aging alteration of cardiac vagosympathetic balance assessed through tone-entropy analysis. J Gerontol A Biol Sci Med Sci. 1999;54:M219–M224

 This study was supported by Grants CA34944, CA40360, HL26490, HL34595, and CA097193 from the National Institutes of Health, Bethesda, Maryland.

PII: S0002-9149(09)00549-9

doi: 10.1016/j.amjcard.2009.01.374

American Journal of Cardiology
Volume 103, Issue 11 , Pages 1572-1577 , 1 June 2009

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