American Journal of Cardiology
Volume 103, Issue 11 , Pages 1495-1499 , 1 June 2009

Usefulness of Abnormal Heart Rate Turbulence to Predict Cardiovascular Mortality in High-Risk Patients With Acute Myocardial Infarction and Left Ventricular Dysfunction (from the EPHESUS Study)

  • Phyllis K. Stein, PhD

      Affiliations

    • Washington University School of Medicine, St. Louis, Missouri
    • Corresponding Author InformationCorresponding author: Tel: 314-286-1350; fax: 314-286-1394
    • ,
  • Prakash Deedwania, MD

      Affiliations

    • UCSF Fresno/VACCHS, Fresno, California

Received 17 November 2008 ,Revised 31 January 2009 ,Accepted 31 January 2009.

References 

  1. Schmidt G, Malik M, Barthel P, Schneider R, Ulm K, Rolnitzky L, et al. Heart-rate turbulence after ventricular premature beats as a predictor of mortality after acute myocardial infarction. Lancet. 1999;353:1390–1396
  2. Ghuran A, Reid F, La Rovere MT, Schmidt G, Bigger JT, Camm AJ, et al. Heart rate turbulence-based predictors of fatal and nonfatal cardiac Arrest (the Autonomic Tone and Reflexes After Myocardial Infarction Study). Am J Cardiol. 2002;89:184–190
  3. Pitt B, Remme W, Zannad F, Neaton J, Martinez F, Roniker B, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003;348:1309–1321
  4. Pitt B, White H, Nicolau J, Martinez F, Gheorghiade M, Aschermann M, et al. Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure. J Am Coll Cardiol. 2005;46:425–431
  5. Stein PK, Barzilay JI, Chaves PM, Mistretta SQ, Domitrovich PP, Gottdeiner JS, et al. Novel measures of heart rate variability predict cardiovascular mortality in older adults independent of traditional cardiovascular risk factors: the Cardiovascular Health Study. J Cardiovasc Electrophysiol. 2008;19:1169–1174
  6. Barthel P, Schneider R, Bauer A, Ulm K, Schmitt C, Schomig A, et al. Risk stratification after acute myocardial infarction by heart rate turbulence. Circulation. 2003;108:1221–1226
  7. Verrier RL, Nearing BD, La Rovere MT, Pinna GD, Mittleman MA, Bigger JT, et al. Ambulatory electrocardiogram-based tracking of T wave alternans in postmyocardial infarction patients to assess risk of cardiac arrest or arrhythmic death. J Cardiovasc Electrophysiol. 2003;14:705–711
  8. Stein PK, Sanghavi D, Domitrovich PP, Deedwania P. Ambulatory ECG-based T-wave alternans predicts sudden cardiac death in high-risk post-MI patients with left ventricular dysfunction in the EPHESUS study. J Cardiovasc Electrophysiol. 2008;19:1037–1042

 This study supported in part by a grant from Pfizer Pharmaceuticals, New York, New York.

PII: S0002-9149(09)00530-X

doi: 10.1016/j.amjcard.2009.01.362

American Journal of Cardiology
Volume 103, Issue 11 , Pages 1495-1499 , 1 June 2009

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