American Journal of Cardiology
Volume 103, Issue 10 , Pages 1451-1456 , 15 May 2009

Relation of Resting Heart Rate to Prognosis in Patients With Idiopathic Pulmonary Arterial Hypertension

  • Ivo R. Henkens, MD, PhD

      Affiliations

    • Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
  • ,
  • Serge A. Van Wolferen, MD

      Affiliations

    • Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
  • ,
  • C. Tji-Joong Gan, MD, PhD

      Affiliations

    • Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
  • ,
  • Anco Boonstra, MD, PhD

      Affiliations

    • Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
  • ,
  • Cees A. Swenne, PhD

      Affiliations

    • Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
  • ,
  • Jos W. Twisk, PhD

      Affiliations

    • Department of Clinical Epidemiology, Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
  • ,
  • Otto Kamp, MD, PhD

      Affiliations

    • Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
  • ,
  • Ernst E. van der Wall, MD, PhD

      Affiliations

    • Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
  • ,
  • Martin J. Schalij, MD, PhD

      Affiliations

    • Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
  • ,
  • Anton Vonk-Noordegraaf, MD, PhD

      Affiliations

    • Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    • Corresponding Author InformationCorresponding author: Tel: 31-20-444-1886; fax: 31-20-444-2377
  • ,
  • Hubert W. Vliegen, MD, PhD

      Affiliations

    • Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands

Received 23 October 2008 ,Revised 21 January 2009 ,Accepted 21 January 2009.

References 

  1. D'Alonzo GE, Barst RJ, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, et al. Survival in patients with primary pulmonary hypertension (Results from a national prospective registry). Ann Intern Med. 1991;115:343–349
  2. Pietra GG, Edwards WD, Kay JM, Rich S, Kernis J, Schloo B, et al. Histopathology of primary pulmonary hypertension (A qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Lung, and Blood Institute, Primary Pulmonary Hypertension Registry). Circulation. 1989;80:1198–1206
  3. Wensel R, Opitz CF, Anker SD, Winkler J, Hoffken G, Kleber FX, et al. Assessment of survival in patients with primary pulmonary hypertension: importance of cardiopulmonary exercise testing. Circulation. 2002;106:319–324
  4. van Wolferen SA, Marcus JT, Boonstra A, Marques KM, Bronzwaer JG, Spreeuwenberg MD, et al. Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension. Eur Heart J. 2007;28:1250–1257
  5. Mahapatra S, Nishimura RA, Sorajja P, Cha S, McGoon MD. Relationship of pulmonary arterial capacitance and mortality in idiopathic pulmonary arterial hypertension. J Am Coll Cardiol. 2006;47:799–803
  6. Gan CT, McCann GP, Marcus JT, van Wolferen SA, Twisk JW, Boonstra A, et al. NT-proBNP reflects right ventricular structure and function in pulmonary hypertension. Eur Respir J. 2006;28:1190–1194
  7. Torbicki A, Kurzyna M, Kuca P, Fijalkowska A, Sikora J, Florczyk M, et al. Detectable serum cardiac troponin T as a marker of poor prognosis among patients with chronic precapillary pulmonary hypertension. Circulation. 2003;108:844–848
  8. Chemla D, Castelain V, Herve P, Lecarpentier Y, Brimioulle S. Haemodynamic evaluation of pulmonary hypertension. Eur Respir J. 2002;20:1314–1331
  9. Provencher S, Chemla D, Herve P, Sitbon O, Humbert M, Simonneau G. Heart rate responses during the 6-minute walk test in pulmonary arterial hypertension. Eur Respir J. 2006;27:114–120
  10. Holverda S, Gan CT, Marcus JT, Postmus PE, Boonstra A, Vonk-Noordegraaf A. Impaired stroke volume response to exercise in pulmonary arterial hypertension. J Am Coll Cardiol. 2006;47:1732–1733
  11. Velez-Roa S, Ciarka A, Najem B, Vachiery JL, Naeije R, Van de Borne P. Increased sympathetic nerve activity in pulmonary artery hypertension. Circulation. 2004;110:1308–1312
  12. Hjalmarson A, Goldstein S, Fagerberg B, Wedel H, Waagstein F, Kjekshus J, et al Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF) (MERIT-HF Study Group). JAMA. 2000;283:1295–1302
  13. Fox K, Borer JS, Camm AJ, Danchin N, Ferrari R, Lopez Sendon JL, et al. Resting heart rate in cardiovascular disease. J Am Coll Cardiol. 2007;50:823–830
  14. Galie N, Torbicki A, Barst R, Dartevelle P, Haworth S, Higenbottam T, et al Guidelines on diagnosis and treatment of pulmonary arterial hypertension (The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology). Eur Heart J. 2004;25:2243–2278
  15. Barst RJ, McGoon M, Torbicki A, Sitbon O, Krowka MJ, Olschewski H, et al. Diagnosis and differential assessment of pulmonary arterial hypertension. J Am Coll Cardiol. 2004;43(suppl S):40S–47S
  16. Crapo RO, Enright PL, Zeballos RJ. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002;166:111–117
  17. Bossone E, Paciocco G, Iarussi D, Agretto A, Iacono A, Gillespie BW, et al. The prognostic role of the ECG in primary pulmonary hypertension. Chest. 2002;121:513–518
  18. Ahearn GS, Tapson VF, Rebeiz A, Greenfield JC. Electrocardiography to define clinical status in primary pulmonary hypertension and pulmonary arterial hypertension secondary to collagen vascular disease. Chest. 2002;122:524–527
  19. Lehtonen J, Sutinen S, Ikaheimo M, Paakko P. Electrocardiographic criteria for the diagnosis of right ventricular hypertrophy verified at autopsy. Chest. 1988;93:839–842
  20. Horner SM, Murphy CF, Coen B, Dick DJ, Harrison FG, Vespalcova Z, et al. Contribution to heart rate variability by mechanoelectric feedback (Stretch of the sinoatrial node reduces heart rate variability). Circulation. 1996;94:1762–1767
  21. Barbieri R, Triedman JK, Saul JP. Heart rate control and mechanical cardiopulmonary coupling to assess central volume: a systems analysis. Am J Physiol Regul Integr Comp Physiol. 2002;283:R1210–R1220
  22. Leineweber K, Brandt K, Wludyka B, Beilfuss A, Ponicke K, Heinroth-Hoffmann I, et al. Ventricular hypertrophy plus neurohumoral activation is necessary to alter the cardiac beta-adrenoceptor system in experimental heart failure. Circ Res. 2002;91:1056–1062
  23. Yeo TC, Dujardin KS, Tei C, Mahoney DW, McGoon MD, Seward JB. Value of a Doppler-derived index combining systolic and diastolic time intervals in predicting outcome in primary pulmonary hypertension. Am J Cardiol. 1998;81:1157–1161
  24. Castelain V, Chemla D, Humbert M, Sitbon O, Simonneau G, Lecarpentier Y, et al. Pulmonary artery pressure-flow relations after prostacyclin in primary pulmonary hypertension. Am J Respir Crit Care Med. 2002;165:338–340
  25. Chang SM, Lin CC, Hsiao SH, Lee CY, Yang SH, Lin SK, et al. Pulmonary hypertension and left heart function: insights from tissue Doppler imaging and myocardial performance index. Echocardiography. 2007;24:366–373
  26. van Wolferen SA, Marcus JT, Westerhof N, Spreeuwenberg MD, Marques KM, Bronzwaer JG, et al. Right coronary artery flow impairment in patients with pulmonary hypertension. Eur Heart J. 2008;29:120–127
  27. Gomez A, Bialostozky D, Zajarias A, Santos E, Palomar A, Martinez ML, et al. Right ventricular ischemia in patients with primary pulmonary hypertension. J Am Coll Cardiol. 2001;38:1137–1142
  28. Sandoval J, Bauerle O, Palomar A, Gomez A, Martinez-Guerra ML, Beltran M, et al. Survival in primary pulmonary hypertension (Validation of a prognostic equation). Circulation. 1994;89:1733–1744
  29. Mahapatra S, Nishimura RA, Oh JK, McGoon MD. The prognostic value of pulmonary vascular capacitance determined by Doppler echocardiography in patients with pulmonary arterial hypertension. J Am Soc Echocardiogr. 2006;19:1045–1050

 This study was supported by an unrestricted research grant from Actelion Pharmaceuticals Nederland Ltd., Woerden, The Netherlands.

PII: S0002-9149(09)00506-2

doi: 10.1016/j.amjcard.2009.01.359

American Journal of Cardiology
Volume 103, Issue 10 , Pages 1451-1456 , 15 May 2009