American Journal of Cardiology
Volume 103, Issue 9 , Pages 1210-1214, 1 May 2009

Impact of Gender and Age on In Vivo Virtual Histology–Intravascular Ultrasound Imaging Plaque Characterization (from the global Virtual Histology Intravascular Ultrasound [VH-IVUS] Registry)

  • Jie Qian, MD

      Affiliations

    • Cardiovascular Research Foundation and Columbia University Medical Center, New York, New York
    • ,
  • Akiko Maehara, MD

      Affiliations

    • Cardiovascular Research Foundation and Columbia University Medical Center, New York, New York
    • Corresponding Author InformationCorresponding author: Tel: 212-851-9371; fax: 212-851-9230
    • ,
  • Gary S. Mintz, MD

      Affiliations

    • Cardiovascular Research Foundation and Columbia University Medical Center, New York, New York
    • ,
  • M. Pauliina Margolis, MD, PhD

      Affiliations

    • Volcano Corporation, Rancho Cordova, California
    • ,
  • Amir Lerman, MD

      Affiliations

    • Mayo Clinic, Rochester, Minnesota
    • ,
  • Jason Rogers, MD

      Affiliations

    • University of California, Sacramento, California
    • ,
  • Shuel Banai, MD

      Affiliations

    • Tel Aviv Medical Center, Tel Aviv, Israel
    • ,
  • Samer Kazziha, MD

      Affiliations

    • Mount Clemens Regional Medical Center, Mt Clemens, Michigan
    • ,
  • Celia Castellanos, MD

      Affiliations

    • Cardiovascular Research Foundation and Columbia University Medical Center, New York, New York
    • ,
  • Lokesh Dani, BS

      Affiliations

    • Cardiovascular Research Foundation and Columbia University Medical Center, New York, New York
    • ,
  • Martin Fahy, MSc

      Affiliations

    • Cardiovascular Research Foundation and Columbia University Medical Center, New York, New York
    • ,
  • Gregg W. Stone, MD

      Affiliations

    • Cardiovascular Research Foundation and Columbia University Medical Center, New York, New York
    • ,
  • Martin B. Leon, MD

      Affiliations

    • Cardiovascular Research Foundation and Columbia University Medical Center, New York, New York

Received 26 December 2008; received in revised form 13 January 2009; accepted 13 January 2009. published online 16 March 2009.

Virtual histology intravascular ultrasound (VH-IVUS) analyses were performed in the first 990 patients enrolled in the 3,000+ patient global VH-IVUS Registry to assess the impact of gender and age on in vivo VH-IVUS plaque characterization. The 990 patients were divided into 3 age group terciles (<58, 58 to 68, and >68 years) and again divided according to gender. In conclusion, (1) both women and men had an increase in plaque with increasing age; (2) at any age, men had more plaque than women; (3) percentages of dense calcium and necrotic core increased with increasing patient age in both men and women; and (4) gender differences were lowest in the oldest tercile (>68 years).

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 Drs. Mintz, Leon, Rogers, and Stone are consultants of Volcano Corp., and Dr. Margolis is an employee of Volcano Corp.

PII: S0002-9149(09)00109-X

doi:10.1016/j.amjcard.2009.01.031

American Journal of Cardiology
Volume 103, Issue 9 , Pages 1210-1214, 1 May 2009

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