American Journal of Cardiology
Volume 103, Issue 8 , Pages 1113-1119 , 15 April 2009

Usefulness of Isosorbide Dinitrate and Hydralazine as Add-on Therapy in Patients Discharged for Advanced Decompensated Heart Failure

  • Wilfried Mullens, MD

      Affiliations

    • Department of Cardiology, Ziekenhuis Oost Limburg, Genk, Belgium
    • ,
  • Zuheir Abrahams, MD, PhD

      Affiliations

    • Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Gary S. Francis, MD

      Affiliations

    • Cardiovascular Diseases Division, University of Minnesota, Minneapolis, Minnesota
    • ,
  • George Sokos, DO

      Affiliations

    • Gerald McGinnis Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania
    • ,
  • Randall C. Starling, MD, MPH

      Affiliations

    • Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, Ohio
    • ,
  • James B. Young, MD

      Affiliations

    • Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, Ohio
    • ,
  • David O. Taylor, MD

      Affiliations

    • Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, Ohio
    • ,
  • W.H. Wilson Tang, MD

      Affiliations

    • Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, Ohio
    • Corresponding Author InformationCorresponding author: Tel: 216-444-2121; fax: 216-445-6165

Received 16 October 2008 ,Revised 21 December 2008 ,Accepted 21 December 2008.

  • Image Result

    Standard oral medication protocols for the Cleveland Clinic HF intensive care unit. ACE-I = ACE inhibitor; QID = 4 times/day; TID = 3 times/day.

    Standard oral medication protocols for the Cleveland Clinic HF intensive care unit. ACE-I = ACE inhibitor; QID = 4 times/day; TID = 3 times/day.

  • Image Result

    Clinical outcomes according to use of different medication regimens at discharge. Kaplan-Meier curves of all-cause mortality (top) and the combined end point of all-cause mortality and HF rehospitaliz

    Clinical outcomes according to use of different medication regimens at discharge. Kaplan-Meier curves of all-cause mortality (top) and the combined end point of all-cause mortality and HF rehospitalization (bottom) between patients who were on an ACE inhibitor or ARB and those on an ACE inhibitor or ARB plus I/H. Abbreviation as in Figure 1.

 Dr. Tang is supported in part by the National Institutes of Health, National Center for Research Resources, CTSA 1UL1RR024989, Cleveland, Ohio.

PII: S0002-9149(09)00035-6

doi: 10.1016/j.amjcard.2008.12.028

American Journal of Cardiology
Volume 103, Issue 8 , Pages 1113-1119 , 15 April 2009

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