American Journal of Cardiology
Volume 103, Issue 7 , Pages 1003-1010 , 1 April 2009

Risk Stratification of Mortality in Patients With Heart Failure and Left Ventricular Ejection Fraction >35%

  • Iwona Cygankiewicz, MD, PhD

      Affiliations

    • Catalan Institute of Cardiovascular Sciences, Barcelona, Spain
    • University of Rochester, Rochester, New York
    • Corresponding Author InformationCorresponding author: Tel: 585-275-5391; fax: 585-273-5283
    • ,
  • Wojciech Zareba, MD, PhD

      Affiliations

    • University of Rochester, Rochester, New York
    • ,
  • Rafael Vazquez, MD, PhD

      Affiliations

    • University Hospital de Valme, Seville, Spain
    • ,
  • Antoni Bayes-Genis, MD, PhD

      Affiliations

    • Hospital Santa Creu i Sant Pau, Barcelona, Spain
    • ,
  • Domingo Pascual, MD, PhD

      Affiliations

    • University Hospital Virgen Arrixaca, Murcia, Spain
    • ,
  • Carlos Macaya, MD, PhD

      Affiliations

    • Hospital Clinico, Madrid, Madrid, Spain
    • ,
  • Jesus Almendral, MD, PhD

      Affiliations

    • Hospital Gregorio Marañon, Madrid, Spain
    • ,
  • Miquel Fiol, MD, PhD

      Affiliations

    • Hospital Son Dureta, Palma de Mallorca, Tarragona, Spain
    • ,
  • Alfredo Bardaji, MD, PhD

      Affiliations

    • Hospital Joan XXIII, Tarragona, Spain
    • ,
  • Jose R. Gonzalez-Juanatey, MD, PhD

      Affiliations

    • University Hospital, Santiago de Compostela, Spain
    • ,
  • Vicente Nieto, MD, PhD

      Affiliations

    • Hospital Insular, Las Palmas, Spain
    • ,
  • Mariano Valdes, MD, PhD

      Affiliations

    • University Hospital Virgen Arrixaca, Murcia, Spain
    • ,
  • Juan Cinca, MD, PhD

      Affiliations

    • Hospital Santa Creu i Sant Pau, Barcelona, Spain
    • ,
  • Antoni Bayes de Luna, MD, PhD

      Affiliations

    • Catalan Institute of Cardiovascular Sciences, Barcelona, Spain
    • ,
  • MUSIC Investigators

Received 12 September 2008 ,Revised 21 November 2008 ,Accepted 21 November 2008.

References 

  1. Schmidt G, Malik M, Barthel P, Schneider R, Ulm K, Rolnitzky L, et al. Heart rate turbulence after ventricular premature beats as a predictor of mortality after myocardial infarction. Lancet. 1999;353:1390–1396
  2. Couderc JP, Xiaojuan X, Zareba W, Moss AJ. Assessment of the stability of the individual-based correction of QT interval for heart rate. Ann Noninvasive Electrocardiol. 2005;10:25–34
  3. Cygankiewicz I, Zareba W, Vazquez R, Almendral J, Bayes-Genis A, Fiol M, et al. Prognostic value of QT/RR slope in predicting mortality in patients with congestive heart failure. J Cardiovasc Electrophysiol. 2008;19:1066–1072
  4. Myerburg RJ, Kessler KM, Castellanos A. Sudden cardiac death: epidemiology, transient risk, and intervention assessment. Ann Intern Med. 1993;119:1187–1197
  5. Task Force for the Diagnosis and Treatment of Congestive Heart Failure of the European Society of Cardiology. Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005). Eur Heart J. 2005;26:1115–1140
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  9. Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, et al Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med. 2005;352:225–237
  10. Moss AJ, Zareba W, Hall WJ, Klein H, Wilber DJ, Cannom DS, et al. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med. 2002;346:877–883
  11. Goldberger JJ, Cain ME, Hohnloser SH, Kadish AH, Knight BP, Lauer MS, et al. Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death (A scientific statement from the American Heart Association Council on Clinical Cardiology Committee on Electrocardiography and Arrhythmias and Council on Epidemiology and Prevention). J Am Coll Cardiol. 2008;52:1179–1199
  12. Kleiger RE, Stein PK, Bigger JT. Heart rate variability: measurement and clinical utility. Ann Noninvasive Electrocardiol. 2005;10:88–101
  13. Cygankiewicz I, Zareba W. Heart rate turbulence—an overview of methods and applications. Folia Cardiol. 2006;13:359–368
  14. Zareba W, Bayes de Luna A. QT dynamics and variability. Ann Noninvasive Electrocardiol. 2005;10:256–262
  15. Exner DV, Kavanagh KM, Slawnych MP, Mitchell LB, Ramadan D, Aggarwal SG, et al Noninvasive risk assessment early after a myocardial infarction. J Am Coll Cardiol. 2007;50:2275–2284
  16. Makikallio TH, Barthel P, Schneider R, Bauer A, Tapanainen JM, Tulppo MP, et al. Prediction of sudden cardiac death after acute myocardial infarction: role of Holter monitoring in the modern treatment era. Eur Heart J. 2005;26:762–769
  17. Klingenheben T, Hohnloser SH. Usefulness of risk stratification for future cardiac events in infarct survivors with severely depressed versus near-normal left ventricular function: results from a prospective long-term follow-up study. Ann Noninvasive Electrocardiol. 2003;8:68–74
  18. Watanabe J, Shinozaki T, Shiba N, Fukahori K, Koseki Y, Karibe A, et al. Accumulation of risk markers predicts the incidence of sudden death inpatients with chronic heart failure. Eur J Heart Fail. 2006;8:237–242
  19. Frenneaux MP. Autonomic changes in patients with heart failure and in post-myocardial infarction patients. Heart. 2004;90:1248–1255

 This work was supported by Grant Code G03/078 from the Instituto de Salud Carlos III, Madrid, Spain.

PII: S0002-9149(08)02207-8

doi: 10.1016/j.amjcard.2008.11.061

American Journal of Cardiology
Volume 103, Issue 7 , Pages 1003-1010 , 1 April 2009

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