American Journal of Cardiology
Volume 103, Issue 7 , Pages 959-968 , 1 April 2009

Effect of Cholesterol Crystals on Plaques and Intima in Arteries of Patients With Acute Coronary and Cerebrovascular Syndromes

  • George S. Abela, MD, MSc

      Affiliations

    • Department of Medicine, Division of Cardiology, Michigan State University, East Lansing, Michigan
    • Department of Physiology, Division of Pathology, Michigan State University, East Lansing, Michigan
    • Corresponding Author InformationCorresponding author: Tel: 517-353-1754; Fax: 517-353-4978
    • ,
  • Kusai Aziz, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, Michigan State University, East Lansing, Michigan
    • ,
  • Ameeth Vedre, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, Michigan State University, East Lansing, Michigan
    • ,
  • Dorothy R. Pathak, PhD

      Affiliations

    • Department of Epidemiology, Michigan State University, East Lansing, Michigan
    • Department of Family Medicine, Michigan State University, East Lansing, Michigan
    • ,
  • John D. Talbott, DO

      Affiliations

    • Section of Cardiothoracic Surgery, E.W. Sparrow Hospital, Lansing, Michigan
    • ,
  • Joyce DeJong, DO

      Affiliations

    • Section of Forensic Pathology, E.W. Sparrow Hospital, Lansing, Michigan

Received 13 November 2008 ,Revised 1 December 2008 ,Accepted 1 December 2008.

References 

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  4. Curran RC. Colour Atlas of Histopathology. 3rd Ed.. New York: Oxford University, Harvey Miller; 1985;103
  5. Abela GS, Aziz K. Cholesterol crystals rupture biological membranes and human plaques during acute cardiovascular events: a novel insight into plaque rupture by scanning electron microscopy. Scanning. 2006;28:1–10
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  7. Vedre A, Pathak DR, Crimp M, Lum C, Koochesfahani M, Abela GS. Physical factors that trigger cholesterol crystallization leading to plaque rupture. Atherosclerosis. 2008;doi:10.1016/j.atherosclerosis.2008.06.027 (Epub ahead of print)
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  17. Ma H, Aziz K, Huang R, Abela GS. Arterial wall cholesterol content is a predictor of development and severity of arterial thrombosis. J Thromb Thrombolysis. 2006;22:5–11
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 This work was supported by Grant No. IRGP147 from Michigan State University, East Lansing, Michigan, and Sparrow Hospital, Lansing, Michigan.

PII: S0002-9149(08)02174-7

doi: 10.1016/j.amjcard.2008.12.019

American Journal of Cardiology
Volume 103, Issue 7 , Pages 959-968 , 1 April 2009

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