American Journal of Cardiology
Volume 103, Issue 6 , Pages 867-871 , 15 March 2009

Association of Uric Acid With Inflammation, Progressive Renal Allograft Dysfunction and Post-Transplant Cardiovascular Risk

  • Farah Bandukwala, MD

      Affiliations

    • Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Michael Huang, MSc

      Affiliations

    • Renal Transplant Program, St. Michael's Hospital, Toronto, Ontario, Canada
    • ,
  • Jeffrey S. Zaltzman, MD

      Affiliations

    • Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    • Renal Transplant Program, St. Michael's Hospital, Toronto, Ontario, Canada
    • ,
  • Michelle M. Nash, MSc

      Affiliations

    • Renal Transplant Program, St. Michael's Hospital, Toronto, Ontario, Canada
    • ,
  • G.V. Ramesh Prasad, MBBS

      Affiliations

    • Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    • Renal Transplant Program, St. Michael's Hospital, Toronto, Ontario, Canada
    • Corresponding Author InformationCorresponding author: Tel: 416-867-3722; fax: 416-867-3709

Received 7 July 2008 ,Revised 13 November 2008 ,Accepted 13 November 2008.

References 

  1. Ducloux D, Kazory A, Chaalopin JM. Predicting coronary heart disease in renal transplant recipients: a prospective study. Kidney Int. 2004;66:441–447
  2. Winkelmayer WC, Lorenz M, Kramar R, Fodinger M, Horl WH, Sunder-Plassmann G. C-reactive protein and body mass index independently predict mortality in kidney transplant recipients. Am J Transplant. 2004;4:1148–1154
  3. Teppo AM, Tornroth T, Honkanen E, Gronhagen-Riska C. Elevated serum C-reactive protein associates with deterioration of renal function in transplant recipients. Clin Nephrol. 2003;60:248–256
  4. Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, Watanabe S, et al. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?. Hypertension. 2003;41:1183–1190
  5. Armstrong KA, Johnson DW, Campbell SB, Isbel NM, Hawley CM. Does uric acid have a pathogenetic role in graft dysfunction and hypertension in renal transplant recipients?. Transplantation. 2005;80:1565–1571
  6. Pearson TA, Mensah GA, Hong Y, Smith SC. CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: overview. Circulation. 2004;110:e543–e544
  7. Akalin E, Ganeshan SV, Winston J, Muntner P. Hyperuricemia is associated with the development of the composite outcomes of new cardiovascular events and chronic allograft nephropathy. Transplantation. 2008;86:652–658
  8. Gerhardt U, Grobe H, Hohage H. Influence of hyperglycemia and hyperuricemia on long-term transplant survival in kidney transplant patients. Clin Transplant. 1999;13:375–379
  9. Akgul A, Bilgic A, Ibis A, Ozdemir FN, Arat Z, Haberal M. Is uric acid a predictive factor for graft dysfunction in renal transplant recipients?. Transplant Proc. 2007;39:1023–1026
  10. Sundstrom J, Sullivan L, D'Agostino RB, Levy D, Kannel WB, Vasan RS. Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence. Hypertension. 2005;45:28–33
  11. Feig DI, Johnson RJ. Hyperuricemia in childhood primary hypertension. Hypertension. 2003;42:247–252
  12. Brand F, McGee D, Kannel W, Stokes J, Castelli W. Hyperuricemia as a risk factor for coronary heart disease: the Framingham study. Am J Epidemiol. 1985;121:11–18
  13. Klein R, Klein B, Cornono J, Maready J, Cassel J, Tyroler H. Serum uric acid (Its relationship to coronary heart disease risk factors and cardiovascular disease). Arch Int Med. 1973;132:401–410
  14. Fang J, Alderman M. Serum uric acid and cardiovascular mortality: the NHANES I epidemiologic follow-up study, 1971–1972. JAMA. 2000;283:2404–2410
  15. Niskanen L, Laaksonen D, Nyssonenen K, Alfthan G, Lakka H-M, Lakka TA, et al. Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men. Arch Intern Med. 2004;164:1546–1551
  16. Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med. 1999;131:7–13

PII: S0002-9149(08)02117-6

doi: 10.1016/j.amjcard.2008.11.042

American Journal of Cardiology
Volume 103, Issue 6 , Pages 867-871 , 15 March 2009

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