American Journal of Cardiology
Volume 103, Issue 6 , Pages 785-790 , 15 March 2009

Left Ventricular Function After ST-Elevation Myocardial Infarction in Patients Treated With Primary Percutaneous Coronary Intervention and Abciximab or Tirofiban (from the Facilitated Angioplasty with Tirofiban or Abciximab [FATA] Trial)

  • Nevio Taglieri, MD

      Affiliations

    • Istituto di Cardiologia, Università di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy
    • Corresponding Author InformationCorresponding author: Tel: 39-051-636-4475; fax: 39-051-636-4477
    • ,
  • Francesco Saia, MD, PhD

      Affiliations

    • Istituto di Cardiologia, Università di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy
    • ,
  • Vincenzo Guiducci, MD

      Affiliations

    • Unità Operativa di Cardiologia Interventistica, Ospedale S. Maria Nuova, Reggio Emilia, Italy
    • ,
  • Stefano Tondi, MD

      Affiliations

    • Unità Operativa di Cardiologia, Ospedale di Baggiovara, Modena, Italy
    • ,
  • Federico Conrotto, MD

      Affiliations

    • Unità Operativa di Cardiologia, Ospedale Molinette, Torino, Italy
    • ,
  • Cinzia Marrozzini, MD

      Affiliations

    • Istituto di Cardiologia, Università di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy
    • ,
  • Guido Rocchi, MD

      Affiliations

    • Istituto di Cardiologia, Università di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy
    • ,
  • Elena Biagini, MD, PhD

      Affiliations

    • Istituto di Cardiologia, Università di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy
    • ,
  • Maria Letizia Bacchi Reggiani, MSc

      Affiliations

    • Istituto di Cardiologia, Università di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy
    • ,
  • Paola Giacometti, MD

      Affiliations

    • Unità Operativa di Cardiologia Interventistica, Ospedale S. Maria Nuova, Reggio Emilia, Italy
    • ,
  • Giancarlo Piovaccari, MD

      Affiliations

    • Unità Operativa di Cardiologia, Ospedale degli Infermi, Rimini, Italy
    • ,
  • Antonio Manari, MD

      Affiliations

    • Unità Operativa di Cardiologia Interventistica, Ospedale S. Maria Nuova, Reggio Emilia, Italy
    • ,
  • Antonio Marzocchi, MD

      Affiliations

    • Istituto di Cardiologia, Università di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy
    • ,
  • FATA Investigators

Received 29 August 2008 ,Revised 13 November 2008 ,Accepted 13 November 2008.

References 

  1. Valgimigli M, Campo G, Percoco G, Bolognese L, Vassanelli C, Colangelo S, et al Comparison of angioplasty with infusion of tirofiban or abciximab and with implantation of sirolimus-eluting or uncoated stents for acute myocardial infarction: the MULTISTRATEGY randomized trial. JAMA. 2008;299:1788–1799
  2. Marzocchi A, Manari A, Piovaccari G, Marrozzini C, Marra S, Magnavacchi P, et al Randomized comparison between tirofiban and abcximab to promote complete ST-resolution in primary angioplasty results of the Facilitated Angioplasty with Tirofiban or Abciximab (FATA) in ST-elevation myocardial infarction trial. Eur Heart J. 2008;29:2972–2980
  3. Santoro GM, Valenti R, Buonamici P, Bolognese L, Cerisano G, Moschi G, et al. Relation between ST-segment changes and myocardial perfusion evaluated by myocardial contrast echocardiography in patients with acute myocardial infarction treated with direct angioplasty. Am J Cardiol. 1998;82:932–937
  4. Claeys MJ, Bosmans J, Veenstra L, Jorens P, De Raedt H, Vrints CJ. Determinants and prognostic implications of persistent ST-segment elevation after primary angioplasty for acute myocardial infarction: importance of microvascular reperfusion injury on clinical outcome. Circulation. 1999;99:1972–1977
  5. Matetzky S, Novikov M, Gruberg L, Freimark D, Feinberg M, Elian D, et al The significance of persistent ST elevation versus early resolution of ST segment elevation after primary PTCA. J Am Coll Cardiol. 1999;34:1932–1938
  6. van't Hof AW, Liem A, de Boer MJ, Zijlstra F Zwolle Myocardial infarction Study Group. Clinical value of 12-lead electrocardiogram after successful reperfusion therapy for acute myocardial infarction. Lancet. 1997;350:615–619
  7. Parodi G, Memisha G, Carrabba N, Signorini U, Migliorini A, Cerisano G, et al. Prevalence, predictors, time course, and long-term clinical implications of left ventricular functional recovery after mechanical reperfusion for acute myocardial infarction. Am J Cardiol. 2007;100:1718–1722
  8. Danzi GB, Sesana M, Capuano C, Mauri L, Berra Centurini P, Baglini R. Comparison in patients having primary coronary angioplasty of abciximab versus tirofiban on recovery of left ventricular function. Am J Cardiol. 2004;94:35–39
  9. Coller BS. Potential non-glycoprotein IIb/IIIa effects of abciximab. Am Heart J. 1999;138:S1–S5
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  11. Clements IP, Christian TF, Higano ST, Gibbons R, Gerh BJ. Residual flow to the infarct zone as a determinant of infarct size after direct angioplasty. Circulation. 1993;88:[part 1]:1527–1533
  12. Iwakura K, Ito H, Kawano S, Shintani Y, Yamamoto K, Kato A, et al. Predictive factors for development of the no-reflow phenomenon in patients with reperfused anterior wall acute myocardial infarction. J Am Coll Cardiol. 2001;38:472–477
  13. De Luca G, Suryapranata H, Ottervanger JP, Hoorntje JC, Gosselink AT, Dambrink JH, et al. Postprocedural single-lead ST-segment deviation and long-term mortality in patients with ST-segment elevation myocardial infarction treated by primary angioplasty. Heart. 2008;94:44–47
  14. Sciagra R, Parodi G, Migliorini A, Valenti R, Antoniucci D, Sotgia B, et al. ST-segment analysis to predict infarct size and functional outcome in acute myocardial infarction treated with primary coronary intervention and adjunctive abciximab therapy. Am J Cardiol. 2006;97:48–54
  15. Neumann FJ, Blasini R, Schmitt C, Alt E, Dirschinger J, Gawaz M, et al. Effect of glycoprotein IIb/IIIa receptor blockade on recovery of coronary flow and left ventricular function after the placement of coronary-artery stents in acute myocardial infarction. Circulation. 1998;98:2695–2701
  16. Petronio AS, Rovai D, Musumeci G, Baglini R, Nardi C, Limbruno U, et al. Effects of abciximab on microvascular integrity and left ventricular functional recovery in patients with acute infarction treated by primary coronary angioplasty. Eur Heart J. 2003;24:67–76

 The FATA trial was a spontaneous, noncompany promoted study almost entirely funded by each participating center and from the Fondazione Fanti-Melloni, a charitable institution linked to the University of Bologna. The study was partially supported with a research grant by Merck & Co., Inc. The company had no role in the study design, the analysis and interpretation of the data, or the drafting or revision of the final manuscript.

PII: S0002-9149(08)02084-5

doi: 10.1016/j.amjcard.2008.11.029

American Journal of Cardiology
Volume 103, Issue 6 , Pages 785-790 , 15 March 2009

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