American Journal of Cardiology
Volume 103, Issue 4 , Pages 471-475 , 15 February 2009

Effect of Acute Myocardial Infarction on Erythrocytic Glutathione Peroxidase 1 Activity and Plasma Vitamin E Levels

  • Mei-ling Cheng, PhD

      Affiliations

    • Graduate Institute of Medical Biotechnology, College of Medicine, Chang Gung University, Kwei-san, Tao-yuan, Taiwan
    • Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Kwei-san, Tao-yuan, Taiwan
    • Department of Clinical Pathology, Chang Gung Memorial Hospital, Kwei-san, Tao-yuan, Taiwan
    • Drs. Cheng, Chen, and Ho contributed equally to this article.
    • ,
  • Chin-ming Chen, MD

      Affiliations

    • Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kwei-san, Tao-yuan, Taiwan
    • Drs. Cheng, Chen, and Ho contributed equally to this article.
    • ,
  • Hung-yao Ho, PhD

      Affiliations

    • Graduate Institute of Medical Biotechnology, College of Medicine, Chang Gung University, Kwei-san, Tao-yuan, Taiwan
    • Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Kwei-san, Tao-yuan, Taiwan
    • Drs. Cheng, Chen, and Ho contributed equally to this article.
    • ,
  • Jui-ming Li, MSc

      Affiliations

    • Graduate Institute of Medical Biotechnology, College of Medicine, Chang Gung University, Kwei-san, Tao-yuan, Taiwan
    • Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Kwei-san, Tao-yuan, Taiwan
    • Department of Laboratory Medicine, Tri-Service General Hospital, Taipei, Taiwan
    • ,
  • Daniel Tsun-yee Chiu, PhD

      Affiliations

    • Graduate Institute of Medical Biotechnology, College of Medicine, Chang Gung University, Kwei-san, Tao-yuan, Taiwan
    • Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Kwei-san, Tao-yuan, Taiwan
    • Department of Clinical Pathology, Chang Gung Memorial Hospital, Kwei-san, Tao-yuan, Taiwan
    • Corresponding Author InformationCorresponding author: Tel and Fax: 886-3-211-8540

Received 13 June 2008 ,Revised 29 September 2008 ,Accepted 29 September 2008.

References 

  1. Bonomini F, Tengattini S, Fabiano A, Bianchi R, Rezzani R. Atherosclerosis and oxidative stress. Histol Histopathol. 2008;23:381–390
  2. Glass CK, Witztum JL. Atherosclerosis (The road ahead). Cell. 2001;104:503–516
  3. Blankenberg S, Rupprecht HJ, Bickel C, Torzewski M, Hafner G, Tiret L, et al. Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease. N Engl J Med. 2003;349:1605–1613
  4. Schnabel R, Lackner KJ, Rupprecht HJ, Espinola-Klein C, Torzewski M, Lubos E, et al. Glutathione peroxidase-1 and homocysteine for cardiovascular risk prediction: results from the AtheroGene Study. J Am Coll Cardiol. 2005;45:1631–1637
  5. Forgione MA, Cap A, Liao R, Moldovan NI, Eberhardt RT, Lim CC, et al. Heterozygous cellular glutathione peroxidase deficiency in the mouse: abnormalities in vascular and cardiac function and structure. Circulation. 2002;106:1154–1158
  6. Torzewski M, Ochsenhirt V, Kleschyov AL, Oelze M, Daiber A, Li H, et al Deficiency of glutathione peroxidase-1 accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2007;27:850–857
  7. Guo Z, Van Remmen H, Yang H, Chen X, Mele J, Vijg J, et al. Changes in expression of antioxidant enzymes affect cell-mediated LDL oxidation and oxidized LDL-induced apoptosis in mouse aortic cells. Arterioscler Thromb Vasc Biol. 2001;21:1131–1138
  8. Parker RA, Sabrah T, Cap M, Gill BT. Relation of vascular oxidative stress, alpha-tocopherol, and hypercholesterolemia to early atherosclerosis in hamsters. Arterioscler Thromb Vasc Biol. 1995;15:349–358
  9. Cachia O, Leger CL, Descomps B. Monocyte superoxide production is inversely related to normal content of alpha-tocopherol in low-density lipoprotein. Atherosclerosis. 1998;138:263–269
  10. Gavrila D, Li WG, McCormick ML, Thomas M, Daugherty A, Cassis LA, et al. Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2005;25:1671–1677
  11. Cyrus T, Yao Y, Rokach J, Tang LX, Pratico D. Vitamin E reduces progression of atherosclerosis in low-density lipoprotein receptor-deficient mice with established vascular lesions. Circulation. 2003;107:521–523
  12. Colak E, Majkic-Singh N, Stankovic S, Sreckovic-Dimitrijevic V, Djordjevic PB, Lalic K, et al. Parameters of antioxidative defense in type 2 diabetic patients with cardiovascular complications. Ann Med. 2005;37:613–620
  13. Yoshida T, Maulik N, Engelman RM, Ho YS, Magnenat JL, Rousou JA, et al. Glutathione peroxidase knockout mice are susceptible to myocardial ischemia reperfusion injury. Circulation. 1997;96:II216–II220
  14. Singh RB, Niaz MA, Sharma JP, Kumar R, Bishnoi I, Begom R. Plasma levels of antioxidant vitamins and oxidative stress in patients with acute myocardial infarction. Acta Cardiol. 1994;49:441–452
  15. Chiu D, Lubin B. Abnormal vitamin E and glutathione peroxidase levels in sickle cell anemia: evidence for increased susceptibility to lipid peroxidation in vivo. J Lab Clin Med. 1979;94:542–548
  16. Katsumata Y, Sato K, Aoki M, Suzuki O, Oya M, Yada S. A simple and accurate method for measurement of the hemoglobin content in blood by colorimetric iron determination. Z Rechtsmed. 1982;88:27–30
  17. Russell MJ, Thomas BS, Wellock E. Simultaneous assay of serum vitamin A and vitamin E by high performance liquid chromatography using time-switched UV and fluorimetric detectors. J High Resolution Chromatogr. 1986;9:281–284
  18. Senthil S, Veerappan RM, Ramakrishna Rao M, Pugalendi KV. Oxidative stress and antioxidants in patients with cardiogenic shock complicating acute myocardial infarction. Clin Chim Acta. 2004;348:131–137
  19. Espinola-Klein C, Rupprecht HJ, Bickel C, Schnabel R, Genth-Zotz S, Torzewski M, et al. Glutathione peroxidase-1 activity, atherosclerotic burden, and cardiovascular prognosis. Am J Cardiol. 2007;99:808–812
  20. Pratico D, Tangirala RK, Rader DJ, Rokach J, FitzGerald GA. Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice. Nat Med. 1998;4:1189–1192
  21. Maor I, Hayek T, Coleman R, Aviram M. Plasma LDL oxidation leads to its aggregation in the atherosclerotic apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 1997;17:2995–3005
  22. Spencer AP, Carson DS, Crouch MA. Vitamin E and coronary artery disease. Arch Intern Med. 1999;159:1313–1320
  23. Milman U, Blum S, Shapira C, Aronson D, Miller-Lotan R, Anbinder Y, et al Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2-2 genotype: a prospective double-blinded clinical trial. Arterioscler Thromb Vasc Biol. 2008;28:341–347
  24. Shekelle PG, Morton SC, Jungvig LK, Udani J, Spar M, Tu W, et al. Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease. J Gen Intern Med. 2004;19:380–389
  25. Robinson I, de Serna DG, Gutierrez A, Schade DS. Vitamin E in humans: an explanation of clinical trial failure. Endocr Pract. 2006;12:576–582
  26. Lonn E, Bosch J, Yusuf S, Sheridan P, Pogue J, Arnold JM, et al. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA. 2005;293:1338–1347
  27. Chan AC, Chow CK, Chiu D. Interaction of antioxidants and their implication in genetic anemia. Proc Soc Exp Biol Med. 1999;222:274–282

 This work was supported by Grants CMRPD160312 and CMRPD160231 from Chang Gung University, Taoyuan, Taiwan; NSC97-2320-B-182-015-MY3, NSC96-2320-B-182A-003-MY3, and NSC96-2320-B-182-015-MY3 from the National Science Council of Taiwan, Taipei, Taiwan; and EMRPD160241 from the Ministry of Education of Taiwan, Taipei.

PII: S0002-9149(08)01875-4

doi: 10.1016/j.amjcard.2008.09.104

American Journal of Cardiology
Volume 103, Issue 4 , Pages 471-475 , 15 February 2009

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