American Journal of Cardiology
Volume 103, Issue 4 , Pages 461-463 , 15 February 2009

Effect of Beta Blockers (Metoprolol or Propranolol) on Effect of Simvastatin in Lowering C-Reactive Protein in Acute Myocardial Infarction

  • Jose C. Quinaglia e Silva, MD

      Affiliations

    • University of Brasilia Medical School, Brasilia, Brazil
    • Hospital de Base do Distrito Federal, Brasilia, Brazil
    • ,
  • Daniel B. Munhoz

      Affiliations

    • University of Brasilia Medical School, Brasilia, Brazil
    • ,
  • Tiago N. Morato

      Affiliations

    • University of Brasilia Medical School, Brasilia, Brazil
    • ,
  • Augusto Gurgel

      Affiliations

    • University of Brasilia Medical School, Brasilia, Brazil
    • ,
  • Antonio C.T. Macedo

      Affiliations

    • University of Brasilia Medical School, Brasilia, Brazil
    • ,
  • Peter Sever, MD, PhD

      Affiliations

    • International Centre for Circulatory Health, Imperial College London, London, United Kingdom
    • ,
  • Andrei C. Sposito, MD, PhD

      Affiliations

    • University of Brasilia Medical School, Brasilia, Brazil
    • Corresponding Author InformationCorresponding author: Tel: 55-61-3442-8439; Fax: 55-61-3442-8489
    • ,
  • Brasilia Heart Study Group

Received 3 August 2008 ,Revised 10 October 2008 ,Accepted 10 October 2008.

References 

  1. Sever P, Dahlof B, Poulter N, Wedel H, Beevers G, Caulfield M, et al Potential synergy between lipid-lowering and blood-pressure-lowering in the Anglo-Scandinavian Cardiac Outcomes Trial. Eur Heart J. 2006;27:2982–2988
  2. Izeboud CA, Monshouwer M, van Miert AS, Witkamp RF. The beta-adrenoceptor agonist clenbuterol is a potent inhibitor of the LPS-induced production of TNF-alpha and IL-6 in vitro and in vivo. Inflamm Res. 1999;48:497–502
  3. Suzuki T, Morisaki H, Serita R, Yamamoto M, Kotake Y, Ishizaka A, et al. Infusion of the beta-adrenergic blocker esmolol attenuates myocardial dysfunction in septic rats. Crit Care Med. 2005;33:2294–2301
  4. Verhoeckx KC, Gaspari M, Bijlsma S, van der Greef J, Witkamp RF, Doornbos RP, et al. In search of secreted protein biomarkers for the anti-inflammatory effect of beta2-adrenergic receptor agonists: application of DIGE technology in combination with multivariate and univariate data analysis tools. J Proteome Res. 2005;4:2015–2023
  5. Correia LC, Sposito AC, Lima JC, Magalhaes LP, Passos LC, Rocha MS, et al. Anti-inflammatory effect of atorvastatin (80 mg) in unstable angina pectoris and non-Q-wave acute myocardial infarction. Am J Cardiol. 2003;92:298–301
  6. Le Tulzo Y, Shenkar R, Kaneko D, Moine P, Fantuzzi G, Dinarello CA, et al. Hemorrhage increases cytokine expression in lung mononuclear cells in mice: involvement of catecholamines in nuclear factor-kappaB regulation and cytokine expression. J Clin Invest. 1997;99:1516–1524
  7. Nakamura A, Johns EJ, Imaizumi A, Yanagawa Y, Kohsaka T. Beta(2)-adrenoceptor agonist suppresses renal tumour necrosis factor and enhances interleukin-6 gene expression induced by endotoxin. Nephrol Dial Transplant. 2000;15:1928–1934

PII: S0002-9149(08)01874-2

doi: 10.1016/j.amjcard.2008.10.007

American Journal of Cardiology
Volume 103, Issue 4 , Pages 461-463 , 15 February 2009

Article Tools

* Image Usage & Resolution