American Journal of Cardiology
Volume 103, Issue 3 , Pages 322-327 , 1 February 2009

Combined Prognostic Utility of White Blood Cell Count, Plasma Glucose, and Glomerular Filtration Rate in Patients Undergoing Primary Stent Placement for Acute Myocardial Infarction

  • Masami Kosuge, MD

      Affiliations

    • Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan
  • ,
  • Kazuo Kimura, MD

      Affiliations

    • Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan
    • Corresponding Author InformationCorresponding author: Tel: 81-45-261-5656; Fax: 81-45-261-9162
  • ,
  • Satoshi Morita, PhD

      Affiliations

    • Department of Biostatistics and Epidemiology, Yokohama City University Medical Center, Yokohama, Japan
  • ,
  • Sunao Kojima, MD

      Affiliations

    • Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
  • ,
  • Tomohiro Sakamoto, MD

      Affiliations

    • Cardiovascular Center, Saiseikai Kumamoto Hospital, Kumamoto, Japan
  • ,
  • Masaharu Ishihara, MD

      Affiliations

    • Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan
  • ,
  • Yujiro Asada, MD

      Affiliations

    • First Department of Pathology, Miyazaki Medical College, Miyazaki, Japan
  • ,
  • Chuwa Tei, MD

      Affiliations

    • Department of Cardiovascular Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, Kagoshima, Japan
  • ,
  • Shunichi Miyazaki, MD

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan
  • ,
  • Masahiro Sonoda, MD

      Affiliations

    • Second Department of Cardiology, National Hospital Kyusyu Cardiovascular Center, Kyushu, Japan
  • ,
  • Kazufumi Tsuchihashi, MD

      Affiliations

    • Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
  • ,
  • Masakazu Yamagishi, MD

      Affiliations

    • Division of Cardiology, Kanazawa University Hospital, Kanazawa, Japan
  • ,
  • Mutsunori Shirai, MD

      Affiliations

    • Department of Microbiology, School of Medicine, Yamaguchi University, Yamaguchi, Japan
  • ,
  • Hisatoyo Hiraoka, MD

      Affiliations

    • Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
  • ,
  • Takashi Honda, MD

      Affiliations

    • Cardiovascular Center, Saiseikai Kumamoto Hospital, Kumamoto, Japan
  • ,
  • Yasuhiro Ogata, MD

      Affiliations

    • Department of Cardiology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan
  • ,
  • Hisao Ogawa, MD

      Affiliations

    • Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
  • ,
  • Japanese Acute Coronary Syndrome Study (JACSS) Investigators

Received 9 August 2008 ,Revised 12 September 2008 ,Accepted 12 September 2008.

References 

  1. Keeley EC, Boura JA, Grines CL. Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet. 2003;361:13–20
  2. Takahashi T, Hiasa Y, Ohara Y, Miyazaki S, Ogura R, Miyajima H, et al. Relation between neutrophil counts on admission, microvascular injury, and left ventricular functional recovery in patients with an anterior wall first acute myocardial infarction treated with primary coronary angioplasty. Am J Cardiol. 2007;100:35–40
  3. Ishihara M, Kojima S, Sakamoto T, Asada Y, Kimura K, Miyazaki S, et al Usefulness of combined white blood cell count and plasma glucose for predicting in-hospital outcomes after acute myocardial infarction. Am J Cardiol. 2006;97:1558–1563
  4. Pellizzon GG, Dixon SR, Stone GW, Cox DA, Mattos L, Boura JA, et al. Relation of admission white blood cell count to long-term outcomes after primary coronary angioplasty for acute myocardial infarction (the Stent PAMI Trial). Am J Cardiol. 2003;91:729–731
  5. Kojima S, Sakamoto T, Ishihara M, Kimura K, Miyazaki S, Tei C, et al The white blood cell count is an independent predictor of no-reflow and mortality following acute myocardial infarction in the coronary interventional era. Ann Med. 2004;36:153–160
  6. Ishihara M, Kojima S, Sakamoto T, Asada Y, Tei C, Kimura K, et al Acute hyperglycemia is associated with adverse outcome after acute myocardial infarction in the coronary intervention era. Am Heart J. 2005;150:814–820
  7. Iwakura K, Ito H, Ikushima M, Kawano S, Okamura A, Asano K, et al Association between hyperglycemia and the no-reflow phenomenon in patients with acute myocardial infarction. J Am Coll Cardiol. 2003;41:1–7
  8. Takahashi T, Hiasa Y, Ohara Y, Miyazaki SI, Mahara K, Ogura R, et al. Acute hyperglycemia prevents the protective effect of pre-infarction angina on microvascular function after primary angioplasty for acute myocardial infarction. Heart. 2008;94:1402–1406
  9. Kosuge M, Kimura K, Kojima S, Sakamoto T, Matsui K, Ishihara M, et al Effects of glucose abnormalities on in-hospital outcome after coronary intervention for acute myocardial infarction. Circ J. 2005;69:375–379
  10. Mielniczuk LM, Pfeffer MA, Lewis EF, Blazing MA, de Lemos JA, Shui A, et al. Estimated glomerular filtration rate, inflammation, and cardiovascular events after an acute coronary syndrome. Am Heart J. 2008;155:725–731
  11. Marenzi G, Moltrasio M, Assanelli E, Lauri G, Marana I, Grazi M, et al. Impact of cardiac and renal dysfunction on inhospital morbidity and mortality of patients with acute myocardial infarction undergoing primary angioplasty. Am Heart J. 2007;153:755–762
  12. Halkin A, Singh M, Nikolsky E, Grines CL, Tcheng JE, Garcia E, et al Prediction of mortality after primary percutaneous coronary intervention for acute myocardial infarction: the CADILLAC risk score. J Am Coll Cardiol. 2005;45:1397–1405
  13. Sadeghi HM, Stone GW, Grines CL, Mehran R, Dixon SR, Lansky AJ, et al Impact of renal insufficiency in patients undergoing primary angioplasty for acute myocardial infarction. Circulation. 2003;108:2769–2775
  14. Kloner RA, Shook T, Antman EM, Cannon CP, Przyklenk K, Yoo K, et al. Prospective temporal analysis of the onset of preinfarction angina versus outcome: an ancillary study in TIMI-9B. Circulation. 1998;97:1042–1045
  15. Brosius FC, Hostetter TH, Kelepouris E, Mitsnefes MM, Moe SM, Moore MA, et al. Detection of chronic kidney disease in patients with or at increased risk of cardiovascular disease. Circulation. 2006;114:1083–1087
  16. The TIMI Study Group. The Thrombolysis in Myocardial Infarction (TIMI) trial. N Engl J Med. 1985;312:932–936
  17. Barron HV, Cannon CP, Murphy SA, Braunwald E, Gibson CM. Association between white blood cell count, epicardial blood flow, myocardial perfusion, and clinical outcomes in the setting of acute myocardial infarction: a Thrombolysis In Myocardial Infarction 10 substudy. Circulation. 2000;102:2329–2334
  18. Kloner RA, Giacomelli F, Alker KJ, Hale SL, Matthews R, Bellows S. Influx of neutrophils into the wall of large epicardial coronary arteries in response to ischemia/reperfusion. Circulation. 1991;84:1758–1772
  19. Mehta JL, Nichols WW, Mehta P. Neutrophil as potential participants in acute myocardial ischemia: relevance to reperfusion. J Am Coll Cardiol. 1988;11:1309–1316
  20. Capes SE, Hunt D, Malmberg K, Gerstein HC. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet. 2000;355:773–778
  21. Ishihara M, Inoue I, Kawagoe T, Shimatani Y, Kurisu S, Hata T, et al. Is admission hyperglycaemia in non-diabetic patients with acute myocardial infarction a surrogate for previously undiagnosed abnormal glucose tolerance?. Eur Heart J. 2006;27:2413–2419
  22. Title LM, Cummings PM, Giddens K, Nassar BA. Oral glucose loading acutely attenuates endothelium-dependent vasodilation in healthy adults without diabetes: an effect prevented by vitamins C and E. J Am Coll Cardiol. 2000;36:2185–2191
  23. Wahab NN, Cowden EA, Pearce NJ, Gardner MJ, Merry H, Cox JL ICONS Investigators. Is blood glucose an independent predictor of mortality in acute myocardial infarction in the thrombolytic era?. J Am Coll Cardiol. 2002;40:1748–1754
  24. Tansey MJB, Opie LH. Plasma glucose on admission to hospital as a metabolic index of the severity of acute myocardial infarction. Can J Cardiol. 1986;2:326–331
  25. Wright RS, Reeder GS, Herzog CA, Albright RC, Williams BA, Dvorak DL, et al. Acute myocardial infarction and renal dysfunction: a high-risk combination. Ann Intern Med. 2002;137:563–570
  26. Gibson CM, Pinto DS, Murphy SA, Morrow DA, Hobbach HP, Wiviott SD, et al. Association of creatinine and creatinine clearance on presentation in acute myocardial infarction with subsequent mortality. J Am Coll Cardiol. 2003;42:1535–1543
  27. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation (Modification of Diet in Renal Disease Study Group). Ann Intern Med. 1999;130:461–470

 This work was supported by Research Grant for Cardiovascular Disease 14C-4 from the Ministry of Health, Labour and Welfare, Tokyo, Japan.

PII: S0002-9149(08)01673-1

doi: 10.1016/j.amjcard.2008.09.079

American Journal of Cardiology
Volume 103, Issue 3 , Pages 322-327 , 1 February 2009