American Journal of Cardiology
Volume 103, Issue 2 , Pages 262-265 , 15 January 2009

Re-examination of the Electrocardiogram in Boys With Duchenne Muscular Dystrophy and Correlation With Its Dilated Cardiomyopathy

  • Philip T. Thrush, MD

      Affiliations

    • Department of Pediatrics, The Ohio State University, Columbus, Ohio
    • Nationwide Children's Hospital, Columbus, Ohio
    • ,
  • Hugh D. Allen, MD

      Affiliations

    • Department of Pediatrics, The Ohio State University, Columbus, Ohio
    • Heart Center, Columbus, Ohio
    • Corresponding Author InformationCorresponding author: Tel: 614-722-2540; fax: 614-722-5638
    • ,
  • Laurence Viollet, PhD

      Affiliations

    • Center for Gene Therapy, Research Institute, Columbus, Ohio
    • ,
  • Jerry R. Mendell, MD

      Affiliations

    • Department of Pediatrics, The Ohio State University, Columbus, Ohio
    • Department of Neurology, The Ohio State University, Columbus, Ohio
    • MDA Clinic, Columbus, Ohio

Received 16 July 2008 ,Revised 28 August 2008 ,Accepted 28 August 2008.

References 

  1. Perloff JK, Roberts WC, deLeon AC. The distinctive electrocardiogram of Duchenne's progressive muscular dystrophy (An electrocardiographic–pathologic correlative study). Am J Med. 1967;42:179–188
  2. Manning GW, Cropp GJ. The electrocardiogram in progressive muscular dystrophy. Br Heart J. 1958;20:416–420
  3. Allen HD, Mendell JR, Hoffman TM. The heart in muscular dystrophies. In:  Allen HD,  Driscoll DJ,  Shaddy RE,  Feltes TF editor. Moss and Adams' Heart Disease in Infants, Children, and Adolescents Including the Fetus and Young Adult. 7th Ed.. Philadelphia, PA: Lippincott Williams & Wilkins; 2008;p. 1234–1242
  4. Bhattacharyya KB, Basu N, Ray TN, Maity B. Profile of electrocardiographic changes in Duchenne muscular dystrophy. J Indian Med Assoc. 1997;95:40–42
  5. Duboc D, Meune C, Lerebours G, Devaux J, Vaksmann G, Bécane H. Effect of perindopril on the onset and progression of left ventricular dysfunction in Duchenne muscular dystrophy. J Am Coll Cardiol. 2005;45:855–857
  6. Duboc D, Meune C, Pierre B, Wahbi K, Eymard B, Toutain A, et al. Perindopril preventative treatment on mortality in Duchenne muscular dystrophy: 10 years' follow-up. Am Heart J. 2007;154:596–602
  7. Ramaciotti C, Heistein LC, Coursey M, Lemler MS, Eapen RS, Iannaccone ST, et al. Left ventricular function and response to enalapril in patients with Duchenne muscular dystrophy during the second decade of life. Am J Cardiol. 2006;98:825–827
  8. Van Hare GF, Dubin AM. The normal electrocardiogram. In:  Allen HD,  Driscoll DJ,  Shaddy RE,  Feltes TF editor. Moss and Adams' Heart Disease in Infants, Children, and Adolescents Including the Fetus and Young Adult. 7th Ed.. Philadelphia, PA: Lippincott Williams & Wilkins; 2008;p. 253–268
  9. Silversides CK, Webb GD, Harris VA, Biggar DW. Effects of deflazacort on left ventricular function in patients with Duchenne muscular dystrophy. Am J Cardiol. 2003;91:769–772
  10. Markham LW, Spicer RL, Khoury PR, Wong BL, Mathews KD, Cripe LH. Steroid therapy and cardiac function in Duchenne muscular dystrophy. Pediatr Cardiol. 2005;26:768–771
  11. Daftary AS, Crisanti M, Kalra M, Wong B, Amin R. Effect of long-term steroids on cough efficiency and respiratory muscle strength in patients with Duchenne muscular dystrophy. Pediatrics. 2007;119(suppl):e320–e324
  12. Markham LW, Kinnett K, Wong BL, Benson DW, Cripe LH. Corticosteroid treatment retards development of ventricular dysfunction in Duchenne muscular dystrophy. Neuromuscul Disord. 2008;18:365–370
  13. Melacini P, Vianello A, Villanova C, Fanin M, Miorin M, Angelini C, et al. Cardiac and respiratory involvement in advanced stage Duchenne muscular dystrophy. Neuromuscul Disord. 1996;6:367–376
  14. Perloff JK. Cardiac rhythm and conduction in Duchenne's muscular dystrophy: a prospective study of 20 patients. J Am Coll Cardiol. 1984;3:1263–1268
  15. Finsterer J, Stollberger C, Feichtinger H. Noncompaction in Duchenne muscular dystrophy: frustrated attempt to create a compensatory left ventricle?. Cardiology. 2006;105:223–225
  16. Finsterer J, Stollberger C, Feichtinger H. Non-compaction on autopsy in Duchenne muscular dystrophy. Cardiology. 2007;108:161–163
  17. Mertens L, Ganame J, Claus P, Goemans N, Thijs D, Eyskens B, et al. Myocardial dysfunction in younger patients with Duchenne muscular dystrophy. J Am Soc Echocardiogr. 2008;21:1049–1054
  18. Silva MC, Meira ZMA, Gurgel Giannetti J, Goemans N, Thijs D, Eyskens B, et al. Myocardial delayed enhancement by magnetic resonance imaging in patients with muscular dystrophy. J Am Coll Cardiol. 2007;49:1874–1879

 The work was supported in part by the Muscular Dystrophy Association, Tucson, Arizona.

PII: S0002-9149(08)01584-1

doi: 10.1016/j.amjcard.2008.08.064

American Journal of Cardiology
Volume 103, Issue 2 , Pages 262-265 , 15 January 2009

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