American Journal of Cardiology
Volume 102, Issue 12 , Pages 1618-1623 , 15 December 2008

Long-Term Outcomes in Patients Undergoing Coronary Stenting on Dual Oral Antiplatelet Treatment Requiring Oral Anticoagulant Therapy

  • Roberta Rossini, MD, PhD

      Affiliations

    • Divisione di Cardiologia, Dipartimento Cardiovascolare, Ospedali Riuniti di Bergamo, Bergamo, Italy
    • Corresponding Author InformationCorresponding author: Tel: 00-39-0-3526-6455; fax: 00-39-0-3540-0491
  • ,
  • Giuseppe Musumeci, MD

      Affiliations

    • Divisione di Cardiologia, Dipartimento Cardiovascolare, Ospedali Riuniti di Bergamo, Bergamo, Italy
  • ,
  • Corrado Lettieri, MD

      Affiliations

    • Divione di Cardiologia, Ospedale Carlo Poma, Mantova, Italy
  • ,
  • Maria Molfese, MD

      Affiliations

    • Divisione di Cardiologia, Ente Ospedaliero Ospedali Galliera, Genova, Italy
  • ,
  • Laurian Mihalcsik, MD

      Affiliations

    • Divisione di Cardiologia, Dipartimento Cardiovascolare, Ospedali Riuniti di Bergamo, Bergamo, Italy
  • ,
  • Paola Mantovani, MD

      Affiliations

    • Divione di Cardiologia, Ospedale Carlo Poma, Mantova, Italy
  • ,
  • Vasile Sirbu, MD

      Affiliations

    • Divisione di Cardiologia, Dipartimento Cardiovascolare, Ospedali Riuniti di Bergamo, Bergamo, Italy
  • ,
  • Theodore A. Bass, MD

      Affiliations

    • University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, United States
  • ,
  • Francesco Della Rovere, MD

      Affiliations

    • Divisione di Cardiologia, Ente Ospedaliero Ospedali Galliera, Genova, Italy
  • ,
  • Antonello Gavazzi, MD

      Affiliations

    • Divisione di Cardiologia, Dipartimento Cardiovascolare, Ospedali Riuniti di Bergamo, Bergamo, Italy
  • ,
  • Dominick J. Angiolillo, MD, PhD

      Affiliations

    • University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, United States

Received 4 June 2008 ,Revised 5 August 2008 ,Accepted 5 August 2008.

References 

  1. Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE, et al ACC/AHA 2007 guidelines for the management of patients with unstable angina/non–ST-elevation myocardial infarction. J Am Coll Cardiol. 2007;50:e1–e157
  2. King SB, Smith SC, Hirshfeld JW, Jacobs AK, Morrison DA, Williams DO, et al 2007 focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice guidelines. J Am Coll Cardiol. 2008;51:172–209
  3. Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345:494–502
  4. Porter A, Konstantino Y, Iakobishvili Z, Shachar L, Battler A, Hasdai D. Short-term triple therapy with aspirin, warfarin, and a thienopyridine among patients undergoing percutaneous coronary intervention. Catheter Cardiovasc Interv. 2006;68:56–61
  5. Orford JL, Fasseas P, Melby S, Burger K, Steinhubl SR, Holmes DR, et al. Safety and efficacy of aspirin, clopidogrel and warfarin after coronary stent placement in patients with an indication for anticoagulation. Am Heart J. 2004;147:463–467
  6. Buresly K, Eisenberg MJ, Zhang X, Pilote L. Bleeding complications associated with combinations of aspirin, thienopyridine derivatives and warfarin in elderly patients following acute myocardial infarction. Arch Int Med. 2005;165:784–789
  7. Rogacka R, Chieffo A, Michev I, Airoldi F, Latib A, Cosgrave J, et al Dual antiplatelet therapy after percutaneous coronary intervention with stent implantation in patients taking chronic oral anticoagulation. J Am Coll Cardiol Intv. 2008;1:56–61
  8. Karjalainen PP, Porela P, Ylitalo A, Vikman S, Nyman K, Vaittinen MA, et al. Safety and efficacy of combined antiplatelet-warfarin therapy after coronary stenting. Eur Heart J. 2007;28:726–732
  9. Khurram Z, Chou E, Minutello R, Bergman G, Parikh M, Naidu S, et al. Combination therapy with aspirin, clopidogrel and warfarin following coronary stenting is associated with a significant risk of bleeding. J Invasive Cardiol. 2006;18:162–164
  10. Nguyen MC, Lim YL, Walton A, Lefkovits J, Agnelli G, Goodman SG, et al. Combining warfarin and antiplatelet therapy after coronary stenting in the Global Registry of Acute Coronary Events: is it safe and effective to use just one antiplatelet agent?. Eur Heart J. 2007;28:1717–1722
  11. Rao AK, Pratt C, Berke A, Jaffe A, Ockene I, Schreiber TL, et al. Thrombolysis In Myocardial Infarction (TIMI) Trial—phase I: hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase. J Am Coll Cardiol. 1988;11:1–11
  12. Ong AT, Hoye A, Aoki J, van Mieghem CA, Rodriguez Granillo GA, Sonnenschein K, et al Thirty-day incidence and six-month clinical outcome of thrombotic stent occlusion after bare-metal, sirolimus, or paclitaxel stent implantation. J Am Coll Cardiol. 2005;45:947–953
  13. McFadden EP, Stabile E, Regar E, Cheneau E, Ong AT, Kinnaird T, et al Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapy. Lancet. 2004;364:1519–1521
  14. The ACTIVE Writing Group on behalf of the ACTIVE Investigators. Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial. Lancet. 2006;367:1903–1912
  15. DeEugenio D, Kolman L, DeCaro M, Andrel J, Chervoneva I, Duong P, et al Risk of major bleeding with concomitant dual antiplatelet therapy after percutaneous coronary intervention in patients receiving long-term warfarin therapy. Pharmacotherapy. 2007;27:691–696
  16. Ruiz-Nodar JM, Marín F, Hurtado JA, Valencia J, Pinar E, Pineda J, et al. Anticoagulant and antiplatelet therapy use in 426 patients with atrial fibrillation undergoing percutaneous coronary intervention and stent implantation implications for bleeding risk and prognosis. J Am Coll Cardiol. 2008;51:818–825
  17. Popma JJ, Berger P, Ohman EM, Harrington RA, Grines C, Weitz J. Antithrombotic therapy in patients undergoing percutaneous coronary intervention. Chest. 2004;126:576S–599S
  18. Rao SV, Eikelboom JA, Granger CB, Harrington RA, Califf RM, Bassand JP. Bleeding and blood transfusion issues in patients with non–ST-segment elevation acute coronary syndromes. Eur Heart J. 2007;28:1193–1204
  19. Eikelboom JW, Mehta SR, Anand SS, Xie C, Fox KA, Yusuf S. Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation. 2006;114:774–782
  20. Rao SV, O'Grady K, Pieper KS, Granger CB, Newby LK, Mahaffey KW, et al. A comparison of the clinical impact of bleeding measured by two different classifications among patients with acute coronary syndromes. J Am Coll Cardiol. 2006;47:809–816
  21. Mehta SR, Granger CB, Eikelboom JW, Bassand JP, Wallentin L, Faxon DP, et al. Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the OASIS-5 trial. J Am Coll Cardiol. 2007;50:1742–1751
  22. Stone GW, Ware JH, Bertrand ME, Lincoff AM, Moses JW, Ohman EM, et al Bivalirudin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a subgroup analysis from the Acute Catheterization and Urgent Intervention Triage strategy (ACUITY) trial. Lancet. 2007;369:907–919
  23. Lancaster GA, Dodd S, Williamson PR. Design and analysis of pilot studies: recommendations for good practice. J Eval Clin Pract. 2004;10:307–312
  24. Gilard M, Arnaud B, Cornily JC, Le Gal G, Lacut K, Le Calvez G, et al. Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study. J Am Coll Cardiol. 2008;51:256–260

PII: S0002-9149(08)01390-8

doi: 10.1016/j.amjcard.2008.08.021

American Journal of Cardiology
Volume 102, Issue 12 , Pages 1618-1623 , 15 December 2008