American Journal of Cardiology
Volume 102, Issue 12 , Pages 1602-1607 , 15 December 2008

Relation of Epicardial Adipose Tissue to Coronary Atherosclerosis

  • Roxana Djaberi, MD

      Affiliations

    • Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    • ,
  • Joanne D. Schuijf, PhD

      Affiliations

    • Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    • ,
  • Jacob M. van Werkhoven

      Affiliations

    • Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    • Interuniversity Cardiology Institute of the Netherlands ICIN, Utrecht, The Netherlands
    • ,
  • Gaetano Nucifora, MD

      Affiliations

    • Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    • ,
  • J. Wouter Jukema, MD, PhD

      Affiliations

    • Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    • Eindhoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    • Interuniversity Cardiology Institute of the Netherlands ICIN, Utrecht, The Netherlands
    • ,
  • Jeroen J. Bax, MD, PhD

      Affiliations

    • Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    • Corresponding Author InformationCorresponding author: Tel: 31-71-526-1757; fax: 31-71-526-6809

Received 3 July 2008 ,Revised 10 August 2008 ,Accepted 10 August 2008.

References 

  1. Mazurek T, Zhang L, Zalewski A, Mannion JD, Diehl JT, Arafat H, et al Human epicardial adipose tissue is a source of inflammatory mediators. Circulation. 2003;108:2460–2466
  2. Iacobellis G, Pistilli D, Gucciardo M, Leonetti F, Miraldi F, Brancaccio G, et al. Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. Cytokine. 2005;29:251–255
  3. Ahn SG, Lim HS, Joe DY, Kang SJ, Choi BJ, Choi SY, et al. Relationship of epicardial adipose tissue by echocardiography to coronary artery disease. Heart. 2008;94:e7
  4. Chaowalit N, Somers VK, Pellikka PA, Rihal CS, Lopez-Jimenez F. Subepicardial adipose tissue and the presence and severity of coronary artery disease. Atherosclerosis. 2006;186:354–359
  5. Gorter PM, van Lindert AS, de Vos AM, Meijs MF, van der Graaf Y, Doevendans PA, et al. Quantification of epicardial and peri-coronary fat using cardiac computed tomography; reproducibility and relation with obesity and metabolic syndrome in patients suspected of coronary artery disease. Atherosclerosis. 2008;197:896–903
  6. Rosito GA, Massaro JM, Hoffmann U, Ruberg FL, Mahabadi AA, Vasan RS, et al. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study. Circulation. 2008;117:605–613
  7. de Vos AM, Prokop M, Roos CJ, Meijs MF, van der Schouw YT, Rutten A, et al. Peri-coronary epicardial adipose tissue is related to cardiovascular risk factors and coronary artery calcification in post-menopausal women. Eur Heart J. 2008;29:777–783
  8. Kanna B, Osorio F, Dharmarajan L. Pericardial fat mimicking pericardial effusion on two-dimensional echocardiography. Echocardiography. 2006;23:400–402
  9. Abbara S, Desai JC, Cury RC, Butler J, Nieman K, Reddy V. Mapping epicardial fat with multi-detector computed tomography to facilitate percutaneous transepicardial arrhythmia ablation. Eur J Radiol. 2006;57:417–422
  10. Kalra DK, Zhu X, Ramchandani MK, Lawrie G, Reardon MJ, Lee-Jackson D, et al. Increased myocardial gene expression of tumor necrosis factor-alpha and nitric oxide synthase-2: a potential mechanism for depressed myocardial function in hibernating myocardium in humans. Circulation. 2002;105:1537–1540
  11. Moreno PR, Purushothaman KR, Fuster V, O'Connor WN. Intimomedial interface damage and adventitial inflammation is increased beneath disrupted atherosclerosis in the aorta: implications for plaque vulnerability. Circulation. 2002;105:2504–2511

 Mr. van Werkhoven is financially supported by a research grant from the Netherlands Society of Cardiology (Utrecht, The Netherlands). Dr. Bax received grants from Medtronic (Minneapolis, Minnesota), Boston Scientific (Natick, Massachusetts), BMS Medical Imaging (North Billerica, Massachusetts), St. Jude Medical (St. Paul, Minnesota), GE Healthcare (Buckinghamshire, United Kingdom), and Edwards Lifesciences (Irvine, California).

PII: S0002-9149(08)01382-9

doi: 10.1016/j.amjcard.2008.08.010

American Journal of Cardiology
Volume 102, Issue 12 , Pages 1602-1607 , 15 December 2008

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