American Journal of Cardiology
Volume 102, Issue 12 , Pages 1577-1582 , 15 December 2008

Magnitude and Prognosis Associated With Ventricular Arrhythmias in Patients Hospitalized With Acute Coronary Syndromes (from the GRACE Registry)

  • Álvaro Avezum, MD, PhD

      Affiliations

    • Dante Pazzanese Institute of Cardiology, Research Division, São Paulo, São Paulo, Brazil
    • Corresponding Author InformationCorresponding author: Tel: 5511-5085-6204; fax: 5511-5573-5091
    • ,
  • Leopoldo S. Piegas, MD, PhD

      Affiliations

    • Dante Pazzanese Institute of Cardiology, Research Division, São Paulo, São Paulo, Brazil
    • ,
  • Robert J. Goldberg, PhD

      Affiliations

    • University of Massachusetts Medical School, Worcester, Massachusetts
    • ,
  • David Brieger, MBBS, PhD

      Affiliations

    • Coronary Care Unit, Concord Hospital, Sydney, New South Wales, Australia
    • ,
  • Martin K. Stiles, MB, ChB

      Affiliations

    • Royal Adelaide Hospital, Adelaide, South Australia, Australia
    • ,
  • Richard Paolini, MD

      Affiliations

    • Coronary Care Unit, Concord Hospital, Sydney, New South Wales, Australia
    • ,
  • Wei Huang, MS

      Affiliations

    • University of Massachusetts Medical School, Worcester, Massachusetts
    • ,
  • Joel M. Gore, MD

      Affiliations

    • University of Massachusetts Medical School, Worcester, Massachusetts
    • ,
  • GRACE Investigators

Received 6 May 2008 ,Revised 2 August 2008 ,Accepted 2 August 2008.

References 

  1. Lown B. Sudden cardiac death: the major challenge confronting contemporary cardiology. Am J Cardiol. 1979;43:313–328
  2. Myerburg RJ, Kessler KM, Castellanos A. Sudden cardiac death: epidemiology, transient risk, and intervention assessment. Ann Intern Med. 1993;119:1187–1197
  3. Pell S, Fayerweather WE. Trends in the incidence of myocardial infarction and in associated mortality and morbidity in a large employed population, 1957–1983. N Engl J Med. 1985;312:1005–1011
  4. Yusuf S, Wittes J, Friedman L. Overview of results of randomized clinical trials in heart disease (I. Treatments following myocardial infarction). JAMA. 1988;260:2088–2093
  5. Ong L, Green S, Reiser P, Morrison J. Early prediction of mortality in patients with acute myocardial infarction: a prospective study of clinical and radionuclide risk factors. Am J Cardiol. 1986;57:33–38
  6. Newby KH, Thompson T, Stebbins A, Topol EJ, Califf RM, Natale A. Sustained ventricular arrhythmias in patients receiving thrombolytic therapy: incidence and outcomes (The GUSTO Investigators). Circulation. 1998;98:2567–2573
  7. The GRACE Investigators. Rationale and design of the GRACE (Global Registry of Acute Coronary Events) Project: a multinational registry of patients hospitalized with acute coronary syndromes. Am Heart J. 2001;141:190–199
  8. Granger CB, Goldberg RJ, Dabbous O, Pieper KS, Eagle KA, Cannon CP, et al. Predictors of hospital mortality in the Global Registry of Acute Coronary Events. Arch Intern Med. 2003;163:2345–2353
  9. Al-Khatib SM, Granger CB, Huang Y, Lee KL, Califf RM, Simoons ML, et al Sustained ventricular arrhythmias among patients with acute coronary syndromes with no ST-segment elevation: incidence, predictors, and outcomes. Circulation. 2002;106:309–312
  10. Van de Werf F, Gore JM, Avezum A, Gulba DC, Goodman SG, Budaj A, et al. Access to catheterisation facilities in patients admitted with acute coronary syndrome: multinational registry study. BMJ. 2005;330:441
  11. Granger CB, Steg PG, Peterson E, Lopez-Sendon J, Van de Werf F, Kline-Rogers E, et al. Medication performance measures and mortality following acute coronary syndromes. Am J Med. 2005;118:858–865
  12. Avezum A, Makdisse M, Spencer F, Gore JM, Fox KA, Montalescot G, et al. Impact of age on management and outcome of acute coronary syndrome: observations from the Global Registry of Acute Coronary Events (GRACE). Am Heart J. 2005;149:67–73
  13. Rahimi K, Watzlawek S, Thiele H, Secknus MA, Hayerizadeh BF, Niebauer J, et al. Incidence, time course, and predictors of early malignant ventricular arrhythmias after non–ST-segment elevation myocardial infarction in patients with early invasive treatment. Eur Heart J. 2006;27:1706–1711

 GRACE is supported by an unrestricted educational grant from Sanofi-Aventis (Paris, France) to the Center for Outcomes Research, University of Massachusetts Medical School, Worcester, Massachusetts. Dr. Avezum, Dr. Brieger, and Dr. Gore also receive funding from Sanofi-Aventis.

PII: S0002-9149(08)01380-5

doi: 10.1016/j.amjcard.2008.08.009

American Journal of Cardiology
Volume 102, Issue 12 , Pages 1577-1582 , 15 December 2008

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