American Journal of Cardiology
Volume 102, Issue 8 , Pages 1002-1008 , 15 October 2008

Clinical and Angiographic Follow-Up of Small Vessel Lesions Treated With Paclitaxel-Eluting Stents (from the TRUE Registry)

  • Cosmo Godino, MD

      Affiliations

    • Interventional Cardiology Unit, San Raffaele Institute, Milan, Italy
    • Corresponding Author InformationCorresponding author: Tel: 39-022-643-4840; fax: 39-022-643-7339
    • ,
  • Shinichi Furuichi, MD

      Affiliations

    • Interventional Cardiology Unit, San Raffaele Institute, Milan, Italy
    • ,
  • Azeem Latib, MD

      Affiliations

    • Interventional Cardiology Unit, San Raffaele Institute, Milan, Italy
    • ,
  • Nuccia Morici, MD

      Affiliations

    • Interventional Cardiology Unit, San Raffaele Institute, Milan, Italy
    • ,
  • Alaide Chieffo, MD

      Affiliations

    • Interventional Cardiology Unit, San Raffaele Institute, Milan, Italy
    • ,
  • Enrico Romagnoli, MD

      Affiliations

    • Interventional Cardiology Unit, San Raffaele Institute, Milan, Italy
    • ,
  • Corrado Tamburino, MD

      Affiliations

    • Clinical Division of Cardiology, Ferrarotto Hospital, Catania, Italy
    • ,
  • Rossella Barbagallo, MD

      Affiliations

    • Clinical Division of Cardiology, Ferrarotto Hospital, Catania, Italy
    • ,
  • Michela Cera, MD

      Affiliations

    • Interventional Cardiology Unit, San Raffaele Institute, Milan, Italy
    • ,
  • David Antoniucci, MD

      Affiliations

    • Division of Cardiology, Careggi Hospital, Florence, Italy
    • ,
  • Omer Goktekin, MD

      Affiliations

    • Department of Cardiology, Royal Brompton Hospital, London, United Kingdom
    • ,
  • Carlo Di Mario, MD

      Affiliations

    • Department of Cardiology, Royal Brompton Hospital, London, United Kingdom
    • ,
  • Bernard Reimers, MD

      Affiliations

    • Cardiology Department, Mirano Hospital, Mirano, Italy
    • ,
  • Eberhard Grube, MD

      Affiliations

    • Department of Cardiology, Heart Center Siegburg, Siegburg, Germany
    • ,
  • Flavio Airoldi, MD

      Affiliations

    • Interventional Cardiology Unit, San Raffaele Institute, Milan, Italy
    • ,
  • Giuseppe M. Sangiorgi, MD

      Affiliations

    • EMO Centro Cuore Columbus, Milan, Italy
    • ,
  • Antonio Colombo, MD

      Affiliations

    • Interventional Cardiology Unit, San Raffaele Institute, Milan, Italy
    • EMO Centro Cuore Columbus, Milan, Italy

Received 19 January 2008 ,Revised 27 May 2008 ,Accepted 27 May 2008.

References 

  1. Wong P, Lau KW, Lim YL, Oesterle SN. Stent placement for non-STRESS/BENESTENT lesions: a critical review. Catheter Cardiovasc Interv. 2000;51:223–233
  2. Kastrati A, Schomig A, Dirschinger J, Mehilli J, Dotzer F, von Welser N, et al. A randomized trial comparing stenting with balloon angioplasty in small vessels in patients with symptomatic coronary artery disease. Circulation. 2000;102:2593–2598
  3. Kastrati A, Schuhlen H, Schomig A. Stenting for small coronary vessels: a contestable winner. J Am Coll Cardiol. 2001;38:1604–1607
  4. Agostoni P, Biondi-Zoccai GGL, Gasparini GL, Anselmi M, Morando G, Turri M, et al. Is bare-metal stenting superior to balloon angioplasty for small vessel coronary artery disease? (Evidence from a meta-analysis of randomized trials). Eur Heart J. 2005;26:881–889
  5. Schofer J, Schlüter M, Gershlick AH, Wijns W, Garcia E, Schampaert E, et al. Sirolimus-eluting stents for treatment of patients with long atherosclerotic lesions in small coronary arteries: double-blind, randomised controlled trial (E-SIRIUS). Lancet. 2003;362:1093–1099
  6. Schampaert E, Cohen EA, Schluter M, Reeves F, Traboulsi M, Title LM, et al. The Canadian study of the sirolimus-eluting stent in the treatment of patients with long de novo lesions in small native coronary arteries (C-SIRIUS). J Am Coll Cardiol. 2004;43:1110–1115
  7. Ardissino D, Cavallini C, Bramucci E, Indolfi C, Marzocchi A, Manari A, et al. Sirolimus-eluting vs uncoated stents for prevention of restenosis in small coronary arteries: a randomized trial. JAMA. 2004;292:2727–2734
  8. Stone GW, Ellis SG, Cox DA, Hermiller J, O'Shaughnessy C, Mann JT, et al. A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease. N Engl J Med. 2004;350:221
  9. Stone GW, Ellis SG, Cannon L, Mann JT, Greenberg JD, Spriggs D, et al. Comparison of a polymer-based paclitaxel-eluting stent with a bare metal stent in patients with complex coronary artery disease: a randomized controlled trial. JAMA. 2005;294:1215–1223
  10. Biondi-Zoccai GGL, Sangiorgi GM, Antoniucci D, Grube E, Di Mario C, Reimers B, et al. Testing prospectively the effectiveness and safety of paclitaxel-eluting stents in over 1000 very high-risk patients: design, baseline characteristics, procedural data and in-hospital outcomes of the multicenter TAXUS in Real-life Usage Evaluation (TRUE) Study. Int J Cardiol. 2007;117:349–354
  11. Cutlip DE, Windecker S, Mehran R, Boam A, Cohen DJ, van Es G-A, et al. Clinical end points in coronary stent trials: a case for standardized definitions. Circulation. 2007;115:2344–2351
  12. Mehran R, Dangas G, Abizaid AS, Mintz GS, Lansky AJ, Satler LF, et al. Angiographic patterns of in-stent restenosis: classification and implications for long-term outcome. Circulation. 1999;100:1872–1878
  13. Mehilli J, Dibra A, Kastrati A, Pache J, Dirschinger J, Schomig A. Intracoronary Drug-Eluting Stenting to Abrogate Restenosis in Small Arteries Study I (Randomized trial of paclitaxel- and sirolimus-eluting stents in small coronary vessels). Eur Heart J. 2006;27:260–266
  14. Juan AF, José MH, José AR, Mariano V, Armando B, Luis I. Early results of direct coronary stenting in consecutive patients when multivessel, complex, long lesions, and small vessels are included. Int J Cardiol. 2005;104:282–287
  15. Airoldi F, Colombo A, Morici N, Latib A, Cosgrave J, Buellesfeld L, et al Incidence and predictors of drug-eluting stent thrombosis during and after discontinuation of thienopyridine treatment. Circulation. 2007;116:745–754
  16. Tanimoto S, Daemen J, Tsuchida K, Garcia-Garcia HM, de Jaegere P, van Domburg RT, et al. Two-year clinical outcome after coronary stenting of small vessels using 2.25-mm sirolimus- and paclitaxel-eluting stents: insight into the RESEARCH and T-SEARCH registries. Catheter Cardiovasc Interv. 2006;69:94–103
  17. Park KH, Park SW, Hong MK, Kim YH, Lee BK, Park DW, et al. Comparison of the effectiveness of sirolimus- and paclitaxel-eluting stents for small coronary artery lesions. Catheter Cardiovasc Interv. 2006;67:589–594
  18. Elezi S, Dibra A, Mehilli J, Pache J, Wessely R, Schömig A, et al. Vessel size and outcome after coronary drug-eluting stent placement results from a large cohort of patients treated with sirolimus- or paclitaxel-eluting stents. J Am Coll Cardiol. 2006;48:1304–1309
  19. Li JJ, Xu B, Yang YJ, Chen JL, Qiao SB, Ma WH, et al. Drug-eluting stent for the treatment of small coronary lesion: comparison between sirollmus- and paclitaxel-eluting stent. Chin Med J (Engl). 2007;120:569–573

 This study was supported with institutional funds of the participating centers. The sponsor Boston Scientific Italia provided free stents to the participating sites and was responsible for the logistics of the trial. The sponsor had no role in the study design, data analysis, and manuscript writing.

PII: S0002-9149(08)01015-1

doi: 10.1016/j.amjcard.2008.05.052

American Journal of Cardiology
Volume 102, Issue 8 , Pages 1002-1008 , 15 October 2008

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