American Journal of Cardiology
Volume 102, Issue 8 , Pages 970-974 , 15 October 2008

Comparison of Peripheral Arterial Response to Mental Stress in Men Versus Women With Coronary Artery Disease

  • Mustafa Hassan, MD

      Affiliations

    • Cardiovascular Research, Division of Cardiology, Department of Medicine, University of Florida, Gainesville, Florida
    • North Florida/South Georgia VA Healthcare System, Gainesville, Florida
    • Corresponding Author InformationCorresponding author: Tel: 352-376-1611; fax: 352-271-4537
  • ,
  • Qin Li, MS

      Affiliations

    • Department of Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville, Florida
  • ,
  • Babette Brumback, PhD

      Affiliations

    • Department of Epidemiology and Biostatistics, College of Public Health and Health Professions, University of Florida, Gainesville, Florida
  • ,
  • Dorian G. Lucey, BA

      Affiliations

    • Cardiovascular Research, Division of Cardiology, Department of Medicine, University of Florida, Gainesville, Florida
    • North Florida/South Georgia VA Healthcare System, Gainesville, Florida
  • ,
  • Melinda Bestland, RN

      Affiliations

    • Cardiovascular Research, Division of Cardiology, Department of Medicine, University of Florida, Gainesville, Florida
    • North Florida/South Georgia VA Healthcare System, Gainesville, Florida
  • ,
  • Gina Eubanks, BS

      Affiliations

    • Cardiovascular Research, Division of Cardiology, Department of Medicine, University of Florida, Gainesville, Florida
    • North Florida/South Georgia VA Healthcare System, Gainesville, Florida
  • ,
  • Roger B. Fillingim, PhD

      Affiliations

    • Department of Community Dentistry and Behavioral Science, College of Dentistry, University of Florida, Gainesville, Florida
  • ,
  • David S. Sheps, MD

      Affiliations

    • Cardiovascular Research, Division of Cardiology, Department of Medicine, University of Florida, Gainesville, Florida
    • North Florida/South Georgia VA Healthcare System, Gainesville, Florida

Received 11 March 2008 ,Revised 2 June 2008 ,Accepted 2 June 2008.

References 

  1. Kneale BJ, Chowienczyk PJ, Cockcroft JR, Coltart DJ, Ritter JM. Vasoconstrictor sensitivity to noradrenaline and NG-monomethyl-l-arginine in men and women. Clin Sci. 1997;93:513–518
  2. Colucci WS, Gimbrone MA, McLaughlin MK, Halpern W, Alexander RW. Increased vascular catecholamine sensitivity and α-adrenergic receptor affinity in female and estrogen-treated male rats. Circ Res. 1982;50:805–811
  3. Freedman RR, Sabharwal SC, Desai N. Sex differences in peripheral vascular adrenergic receptors. Circ Res. 1987;61:581–585
  4. Kneale BJ, Chowienczyk PJ, Brett SE, Coltart DJ, Ritter JM. Gender differences in sensitivity to adrenergic agonists of forearm resistance vasculature. J Am Coll Cardiol. 2000;36:1233–1238
  5. Li Z, Duckles SP. Influence of gender on vascular reactivity in the rat. J Pharmacol Exp Ther. 1994;286:1426–1431
  6. Sudhir K, Elser MD, Jennings GL, Komesaroff PA. Estrogen supplementation decreases norepinephrine-induced vasoconstriction and total body norepinephrine spillover in perimenopausal women. Hypertension. 1997;30:1538–1543
  7. Sudhir K, Jennings GL, Funder JW, Komesaroff PA. Estrogen enhances basal nitric oxide release in the forearm vasculature in perimenopausal women. Hypertension. 1996;28:330–334
  8. Forte P, Copland M, Smith LM, Milne E, Sutherland J, Benjamin N. Basal nitric oxide synthesis in essential hypertension. Lancet. 1997;349:837–842
  9. Jiang W, Babyak M, Krantz DS, Waugh RA, Coleman RE, Hanson MM, et al. Mental stress-induced myocardial ischemia and cardiac events. JAMA. 1996;275:1651–1656
  10. Jain D, Burg M, Soufer A, Zaret BL. Prognostic implications of mental stress-induced silent left ventricular dysfunction in patients with stable angina pectoris. Am J Cardiol. 1995;76:31–35
  11. Krantz DS, Santiago HT, Kop JW, Bairey Merz CN, Rozanski A, Gottdiener JS. Prognostic value of mental stress testing in coronary artery disease. Am J Cardiol. 1999;84:1292–1297
  12. Sheps DS, McMahon RP, Becker L, Carney RM, Freedland KE, Cohen JD, et al Mental stress-induced ischemia and all-cause mortality in patients with coronary artery disease: results from the Psychophysiological Investigations of Myocardial Ischemia study. Circulation. 2002;105:1780–1784
  13. Kaufmann PG, McMahon RP, Becker LC, Bertolet B, Bonsall R, Chaitman B, et al The Psychophysiological Investigations of Myocardial Ischemia (PIMI) study: objective, methods, and variability of measures. Psychosom Med. 1998;60:56–63
  14. Goor DA, Sheffy J, Schnall RP, Arditti A, Caspi A, Bragdon EE, et al. Peripheral arterial tonometry: a diagnostic method for detection of myocardial ischemia induced during mental stress tests: a pilot study. Clin Cardiol. 2004;27:137–141
  15. Gottdiener JS, Krantz DS, Howell RH, Hecht GM, Klein J, Falconer JJ, et al. Induction of silent myocardial ischemia with mental stress testing: relation to the triggers of ischemia during daily life activities and to ischemic functional severity. J Am Coll Cardiol. 1994;24:1645–1651
  16. Gullette EC, Blumenthal JA, Babyak M, Jiang W, Waugh RA, Frid DJ, et al. Effects of mental stress on myocardial ischemia during daily life. JAMA. 1997;277:1521–1526
  17. Gabbay FH, Krantz DS, Kop WJ, Hedges SM, Klein J, Gottdiener JS, et al. Triggers of myocardial ischemia during daily life in patients with coronary artery disease: physical and mental activities, anger and smoking. J Am Coll Cardiol. 1996;27:585–592
  18. Stone PH, Krantz DS, McMahon RP, Goldberg AD, Becker LC, Chaitman BR, et al Relationship among mental stress-induced ischemia and ischemia during daily life and during exercise: the Psychophysiologic Investigations of Myocardial Ischemia (PIMI) study. J Am Coll Cardiol. 1999;33:1476–1484
  19. Blumenthal JA, Jiang W, Waugh RA, Frid DJ, Morris JJ, Coleman RE, et al. Mental stress-induced ischemia in the laboratory and ambulatory ischemia during daily life. Circulation. 1995;92:2102–2108
  20. Spieker LE, Hurlimann D, Ruschitzka F, Corti R, Enseleit F, Shaw S, et al. Mental stress induces prolonged endothelial dysfunction via endothelin-A receptors. Circulation. 2002;105:2817–2820
  21. Mendelsohn ME. Nongenomic, ER-mediated activation of endothelial nitric oxide synthase: how does it work? (What does it mean?). Circ Res. 2000;87:956–960
  22. Arnal JF, Clamens S, Pechet C, Negre-Salvayre A, Allera C, Girolami JP, et al. Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine aortic endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production. Proc Natl Acad Sci U S A. 1996;93:4108–4113
  23. Darblade B, Pendaries C, Krust A, Dupont S, Fouque MJ, Rami J, et al. Estradiol alters nitric oxide production in the mouse aorta through the alpha-, but not beta-, estrogen receptor. Circ Res. 2002;90:413–419
  24. Martin P, Lee H-S. Indicators of active and passive coping in myocardial infarction victims. J Gerontol Psychol Sci. 1992;47:238–241
  25. Bogg J, Thornton E, Bundred P. Gender variability in mood, quality of life and coping following primary myocardial infarction. Coronary Health Care. 2000;4:163–168
  26. LaCharity LA. The experiences of younger women with coronary artery disease. J Women's Health Gend Based Med. 1999;8:773–785
  27. York KM, Hassan M, Li Q, Li H, Fillingim RB, Lucey D, et al. Do men and women differ on measures of mental stress-induced ischemia?. Psychosom Med. 2007;69:918–922
  28. Kannel WB, Abbott RD. Incidence and prognosis of myocardial infarction in women (The Framingham Study). In:  Eaker ED,  Packard B,  Wenger NK,  Clarkson TB,  Tyroler HA editor. Coronary Heart Disease in Women. New York: Haymaker Doymer; 1987;p. 208–214
  29. Lerner DJ, Kannel WB. Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population. Am Heart J. 1986;3:383–390

 This study was supported by Grants HL 070265 and HL 072059 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland. This material was also the result of work supported with resources and use of facilities at the Department of Veterans Affairs Medical Center, Gainesville, Florida.

PII: S0002-9149(08)01007-2

doi: 10.1016/j.amjcard.2008.06.015

American Journal of Cardiology
Volume 102, Issue 8 , Pages 970-974 , 15 October 2008