American Journal of Cardiology
Volume 102, Issue 7 , Pages 835-841 , 1 October 2008

Epidemiology, Heritability, and Genetic Linkage of C-Reactive Protein in African Americans (from the Jackson Heart Study)

  • Ervin R. Fox, MD, MPH

      Affiliations

    • University of Mississippi School of Medicine, Jackson, Mississippi
    • Corresponding Author InformationCorresponding author: Tel: 601-984-5630; fax: 601-984-2631
  • ,
  • Emelia J. Benjamin, MD, ScM

      Affiliations

    • Boston University School of Medicine, Boston, Massachusetts
  • ,
  • Daniel F. Sarpong, PhD

      Affiliations

    • Jackson State University, Jackson, Mississippi
  • ,
  • Charles N. Rotimi, PhD

      Affiliations

    • Howard University, Washington, District of Columbia
  • ,
  • James G. Wilson, MD

      Affiliations

    • G. V. Sonny Montgomery Veterans Affairs Medical Center, Jackson, Mississippi
  • ,
  • Michael W. Steffes, MD, PhD

      Affiliations

    • University of Minnesota, Minneapolis, Minnesota
  • ,
  • Guanjie Chen, MD

      Affiliations

    • Howard University, Washington, District of Columbia
  • ,
  • Adebowale Adeyemo, MD

      Affiliations

    • Howard University, Washington, District of Columbia
  • ,
  • Jason K. Taylor, MD

      Affiliations

    • University of Mississippi School of Medicine, Jackson, Mississippi
  • ,
  • Tandaw E. Samdarshi, MD, MPH

      Affiliations

    • University of Mississippi School of Medicine, Jackson, Mississippi
  • ,
  • Herman A. Taylor Jr., MD, MPH

      Affiliations

    • University of Mississippi School of Medicine, Jackson, Mississippi

Received 7 February 2008 ,Revised 4 May 2008 ,Accepted 4 May 2008.

References 

  1. Kathiresan S, Larson MG, Vasan RS, Guo CY, Gona P, Keaney JF, et al Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level. Circulation. 2006;113:1415–1423
  2. Koenig W, Sund M, Frohlich M, Fischer HG, Lowel H, Doring A, et al. C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992. Circulation. 1999;99:237–242
  3. Tracy RP, Psaty BM, Macy E, Bovill EG, Cushman M, Cornell ES, et al. Lifetime smoking exposure affects the association of C-reactive protein with cardiovascular disease risk factors and subclinical disease in healthy elderly subjects. Arterioscler Thromb Vasc Biol. 1997;17:2167–2176
  4. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease. Circulation. 1998;97:425–428
  5. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 1997;336:973–979
  6. Ridker PM, Glynn RJ, Hennekens CH. C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction. Circulation. 1998;97:2007–2011
  7. Danesh J, Collins R, Appleby P, Peto R. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA. 1998;279:1477–1482
  8. Taylor HA, Wilson JG, Jones DW, Sarpong DF, Srinivasan A, Garrison RJ, et al. Toward resolution of cardiovascular health disparities in African Americans: design and methods of the Jackson Heart Study. Ethn Dis. 2005;15(suppl):S6-4–S6-17
  9. Fuqua SR, Wyatt SB, Andrew ME, Sarpong DF, Henderson FR, Cunningham MF, et al. Recruiting African-American research participation in the Jackson Heart Study: methods, response rates, and sample description. Ethn Dis. 2005;15(suppl):S6-18–S6-29
  10. Wilson JG, Rotimi CN, Ekunwe L, Royal CD, Crump ME, Wyatt SB, et al. Study design for genetic analysis in the Jackson Heart Study. Ethn Dis. 2005;15(suppl):S6-30–S6-37
  11. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003;289:2560–2572
  12. Genuth S, Alberti KG, Bennett P, Buse J, Defronzo R, Kahn R, et al Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care. 2003;26:3160–3167
  13. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  14. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO, Criqui M, et al Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107:499–511
  15. Almasy L, Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet. 1998;62:1198–1211
  16. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. Merlin—rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet. 2002;30:97–101
  17. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet. 1995;11:241–247
  18. Wong ND, Pio J, Valencia R, Thakal G. Distribution of C-reactive protein and its relation to risk factors and coronary heart disease risk estimation in the National Health and Nutrition Examination Survey (NHANES) III. Prev Cardiol. 2001;4:109–114
  19. Khera A, McGuire DK, Murphy SA, Stanek HG, Das SR, Vongpatanasin W, et al. Race and gender differences in C-reactive protein levels. J Am Coll Cardiol. 2005;46:464–469
  20. Wener MH, Daum PR, McQuillan GM. The influence of age, sex, and race on the upper reference limit of serum C-reactive protein concentration. J Rheumatol. 2000;27:2351–2359
  21. Albert MA, Glynn RJ, Buring J, Ridker PM. C-reactive protein levels among women of various ethnic groups living in the United States (from the Women's Health Study). Am J Cardiol. 2004;93:1238–1242
  22. Lakoski SG, Herrington DM, Siscovick DM, Hulley SB. C-reactive protein concentration and incident hypertension in young adults: the CARDIA study. Arch Intern Med. 2006;166:345–349
  23. Festa A, Hanley AJ, Tracy RP, D'Agostino R, Haffner SM. Inflammation in the prediabetic state is related to increased insulin resistance rather than decreased insulin secretion. Circulation. 2003;108:1822–1830
  24. Temelkova-Kurktschiev T, Siegert G, Bergmann S, Henkel E, Koehler C, Jaross W, et al. Subclinical inflammation is strongly related to insulin resistance but not to impaired insulin secretion in a high risk population for diabetes. Metabolism. 2002;51:743–749
  25. Reiner AP, Carlson CS, Ziv E, Iribarren C, Jaquish CE, Nickerson DA. Genetic ancestry, population sub-structure, and cardiovascular disease-related traits among African-American participants in the CARDIA Study. Hum Genet. 2007;121:565–575
  26. Pankow JS, Folsom AR, Cushman M, Borecki IB, Hopkins PN, Eckfeldt JH, et al. Familial and genetic determinants of systemic markers of inflammation: the NHLBI Family Heart Study. Atherosclerosis. 2001;154:681–689
  27. Dupuis J, Larson MG, Vasan RS, Massaro JM, Wilson PW, Lipinska I, et al. Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study: evidence for susceptibility loci on 1q. Atherosclerosis. 2005;182:307–314
  28. Lange LA, Carlson CS, Hindorff LA, Lange EM, Walston J, Durda JP, et al Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events. JAMA. 2006;296:2703–2711

 The Jackson Heart Study is a collaborative study supported by the National Institutes of Health, Bethesda, Maryland, and the National Center on Minority Health and Health Disparities, Bethesda, Maryland (study ID numbers 5001, N01 HC95170, N01 HC95171, and N01 HC95172) in partnership with 3 local institutions (the University of Mississippi Medical Center, Jackson, Mississippi; Jackson State University, Jackson, Mississippi; and Tougaloo College, Jackson, Mississippi). Dr. Fox's work on this project is supported by Grant 0555209B from the American Heart Association, Dallas Texas. Dr. Benjamin's work on this project is supported by NIH Grants HL076784 and AG028321, Framingham, Massachusetts.

PII: S0002-9149(08)00913-2

doi: 10.1016/j.amjcard.2008.05.049

American Journal of Cardiology
Volume 102, Issue 7 , Pages 835-841 , 1 October 2008