Epidemiology, Heritability, and Genetic Linkage of C-Reactive Protein in African Americans (from the Jackson Heart Study)

Age- and gender-adjusted relation of obesity, insulin resistance (IR; in participants without diabetes mellitus [DM]), and DM to CRP concentration. Log CRP concentrations were age and gender adjusted; back-transformed geometric means are displayed. SAS omits records with a single missing datum. Note that missing data may occur for different measures and not the same measure. ^*Assessed for a significant difference in CRP concentration between subjects with versus without obesity after adjusting for DM and IR. ^†Assessed for a significant difference in CRP concentrations adjusting for obesity between participants without DM who did not have IR (referent group) compared with participants without DM who had IR and participants with DM. There was no significant interaction between obesity, IR (in participants without DM), and DM. There were 171 missing data on IR status (“IR no” and “IR yes”) due to missing data on fasting insulin and/or fasting glucose. There was no significant difference between DM and “IR yes” for subjects who were not obese. Similar results were true for obese subjects. No difference was found between groups denoted by the same letter; differences were found between groups denoted by different letters.

Multipoint logarithm of odds (LOD) scores by chromosome (CHR) for log-transformed CRP, adjusted for age, gender, and BMI.