American Journal of Cardiology
Volume 102, Issue 6 , Pages 658-662 , 15 September 2008

Right Ventricular Cardiomyocyte Apoptosis in Patients With Acute Myocardial Infarction of the Left Ventricular Wall

  • Antonio Abbate, MD

      Affiliations

    • Virginia Commonwealth University Pauley Heart Center, Richmond, Virginia
    • Corresponding Author InformationCorresponding author: Tel: 804-270-2946; fax: +1-360-323-1204
    • ,
  • Rossana Bussani, MD

      Affiliations

    • Institutes of Cardiology and Anatomic Pathology, University of Trieste, Trieste, Italy
    • ,
  • Gianfranco Sinagra, MD

      Affiliations

    • Institutes of Cardiology and Anatomic Pathology, University of Trieste, Trieste, Italy
    • ,
  • Elena Barresi, MD

      Affiliations

    • Institutes of Cardiology and Anatomic Pathology, University of Trieste, Trieste, Italy
    • ,
  • Alberto Pivetta, MD

      Affiliations

    • Institutes of Cardiology and Anatomic Pathology, University of Trieste, Trieste, Italy
    • ,
  • Andrea Perkan, MD

      Affiliations

    • Institutes of Cardiology and Anatomic Pathology, University of Trieste, Trieste, Italy
    • ,
  • Nicholas H. Hoke, BS

      Affiliations

    • Virginia Commonwealth University Pauley Heart Center, Richmond, Virginia
    • ,
  • Fadi N. Salloum, PhD

      Affiliations

    • Virginia Commonwealth University Pauley Heart Center, Richmond, Virginia
    • ,
  • Michael C. Kontos, MD

      Affiliations

    • Virginia Commonwealth University Pauley Heart Center, Richmond, Virginia
    • ,
  • Giuseppe G.L. Biondi-Zoccai, MD

      Affiliations

    • Department of Cardiology, University of Turin, Turin, Italy
    • ,
  • George W. Vetrovec, MD

      Affiliations

    • Virginia Commonwealth University Pauley Heart Center, Richmond, Virginia
    • ,
  • Gastone Sabbadini, MD

      Affiliations

    • Institutes of Cardiology and Anatomic Pathology, University of Trieste, Trieste, Italy
    • ,
  • Feliciano Baldi, MD

      Affiliations

    • Department of Biochemistry, Section of Pathology, Second University of Naples, Naples, Italy
    • ,
  • Furio Silvestri, MD

      Affiliations

    • Virginia Commonwealth University Pauley Heart Center, Richmond, Virginia
    • ,
  • Rakesh C. Kukreja, PhD

      Affiliations

    • Virginia Commonwealth University Pauley Heart Center, Richmond, Virginia
    • ,
  • Alfonso Baldi, MD

      Affiliations

    • Department of Biochemistry, Section of Pathology, Second University of Naples, Naples, Italy

Received 11 March 2008 ,Revised 4 May 2008 ,Accepted 4 May 2008.

References 

  1. Patten RD, Aronovitz MJ, Deras-Meja L, Pandian NG, Hanak GG, Smith HJ, et al. Ventricular remodeling in a mouse model of myocardial infarction. Am J Physiol. 1998;274:H1812–H1820
  2. Brower GL, Janicki JS. Contribution of ventricular remodeling to pathogenesis of heart failure in rats. Am J Physiol. 2001;280:H674–H683
  3. Hirose K, Shu NH, Reed JE, Rumberger JA. Right ventricular dilatation and remodeling the first year after an initial transmural wall left ventricular myocardial infarction. Am J Cardiol. 1993;72:1126–1130
  4. Oakley C. Importance of right ventricular function in congestive heart failure. Am J Cardiol. 1988;62(suppl):14A–19A
  5. Di Salvo TG, Mathier M, Semigran MJ, Dec GW. Preserved right ventricular ejection fraction predicts exercise capacity and survival in advanced heart failure. J Am Coll Cardiol. 1995;25:1143–1153
  6. Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction—experimental observations and clinical implications. Circulation. 1990;81:1161–1172
  7. Anversa P, Olivetti G, Capasso JM. Cellular basis of ventricular remodeling after myocardial infarction. Am J Cardiol. 1991;68(suppl):7D–16D
  8. Krijnen PAJ, Nijmeijer R, Meijer CJLM, Visser CA, Hack CE, Niessen HWM. Apoptosis in myocardial ischaemia and infarction. J Clin Pathol. 2002;55:801–811
  9. Abbate A, Biondi-Zoccai GGL, Baldi A. Pathophysiologic role of myocardial apoptosis in post-infarction left ventricular remodeling. J Cell Physiol. 2002;193:145–153
  10. Baldi A, Abbate A, Bussani R, Patti G, Melfi R, Angelini A, et al. Apoptosis and post-infarction left ventricular remodeling. J Mol Cell Cardiol. 2002;34:165–174
  11. Abbate A, Biondi-Zoccai GGL, Bussani R, Dobrina A, Camilot D, Feroce F, et al. Increased myocardial apoptosis in patients with unfavorable left ventricular remodeling and early symptomatic post-infarction heart failure. J Am Coll Cardiol. 2003;41:753–760
  12. Bussani R, Abbate A, Biondi-Zoccai GG, Dobrina A, Leone AM, Camilot D, et al. Right ventricular dilatation after left ventricular acute myocardial infarction is predictive of extremely high peri-infarctual apoptosis at postmortem examination in humans. J Clin Pathol. 2003;56:672–678
  13. Biondi-Zoccai GG, Abbate A, Vasaturo F, Scarpa S, Santini D, Leone AM, et al Increased apoptosis in remote non-infarcted myocardium in multivessel coronary disease. Int J Cardiol. 2004;94:105–110
  14. Sinagra G, Bussani R, Abbate A, Piro M, Biondi-Zoccai GG, Kontos MC, et al Left ventricular diastolic filling pattern at Doppler echocardiography and apoptotic rate in fatal acute myocardial infarction. Am J Cardiol. 2007;99:307–309
  15. Hunt SA, Baker DW, Chin Mh, Cinquegrani MP, Feldman AM, Francis GS, et al American College of Cardiology/American Heart Association ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. J Am Coll Cardiol. 2001;38:2101–2113
  16. Voelkel NF, Quaife RA, Leinwand LA, Barst RJ, McGoon MD, Meldrum DR, et al Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure. Circulation. 2006;114:1883–1891
  17. Sabbah HN, Stein PD, Kono T, Gheorghiade M, Levine TB, Jafri S, et al. A canine model of chronic heart failure produced by multiple sequential coronary microembolization. Am J Physiol. 1991;260:H1379–H1384
  18. Ferlinz J. Right ventricular function in adult cardiovascular disease. Prog Cardiovasc Dis. 1982;25:225–267
  19. Gibson CM, Ryan KA, Murphy SA, Mesley R, Marble SJ, Giugliano RP, et al. Impaired coronary blood flow in nonculprit arteries in the setting of acute myocardial infarction. J Am Coll Cardiol. 1999;34:974–982
  20. Araujo LI, Camici P, Spinks TJ, Jones T, Maseri A. Abnormalities in myocardial metabolism in patients with unstable angina as assessed by positron emission tomography. Cardiovasc Drugs Ther. 1988;2:41–46

 Dr. Abbate was supported by a grant from the Jeffress Memorial Trust Fund, Richmond, Virginia; Dr. Baldi was supported by a grant from Futura Onlus, Rome, Italy (a not-for-profit organization); and Dr. Kukreja was supported by Grants HL51045, HL59469, and HL79424 from the National Institutes of Health, Bethesda, Maryland.

PII: S0002-9149(08)00828-X

doi: 10.1016/j.amjcard.2008.05.007

American Journal of Cardiology
Volume 102, Issue 6 , Pages 658-662 , 15 September 2008

Article Tools

* Image Usage & Resolution