American Journal of Cardiology
Volume 102, Issue 4 , Pages 401-403 , 15 August 2008

Comparison of Higher Clopidogrel Loading and Maintenance Dose to Standard Dose on Platelet Function and Outcomes After Percutaneous Coronary Intervention Using Drug-Eluting Stents

Received 22 January 2008 ,Revised 29 March 2008 ,Accepted 29 March 2008.

References 

  1. Patel P, Gonzalez R, Bobek J, Dokainish H, Lakkis N. Impact of ADP and calcium chelation on platelet aggregation testing in patients on clopidogrel therapy. J Am Coll Cardiol. 2006;47:464–465
  2. Rao AK, Pratt C, Berke A, Ockene I, Schreiber TL, Bell WR, et al. Thrombolysis In Myocardial Infarction (TIMI) trial—phase I: hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase. J Am Coll Cardiol. 1988;11:1–11
  3. Bertrand ME, Rupprecht HJ, Urban P, Gershlick AH CLASSICS Investigators. Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin after coronary stenting: the Clopidogrel Aspirin Stent International Cooperative Study (CLASSICS). Circulation. 2000;102:624–629
  4. CURE Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345:494–502
  5. Hochholzer W, Trenk D, Bestehorn HP, Fischer B, Valina CM, Ferenc M, et al. Impact of the degree of peri-interventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement. J Am Coll Cardiol. 2006;48:1742–1750
  6. Cuisset T, Frere C, Quilici J, Morange PE, Nait-Saidi L, Carvajal J, et al. Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non–ST-segment elevation acute coronary syndrome undergoing coronary stenting. J Am Coll Cardiol. 2006;48:1339–1345
  7. Müller I, Besta F, Schulz C, Massberg S, Schönig A, Gawaz M. Prevalence of clopidogrel non-responders among patients with angina pectoris scheduled for elective coronary stent placement. Thromb Haemost. 2003;89:783–787
  8. Bates ER, Lau WC, Bleske BE. Loading pretreatement and interindividual variability issues with clopidogrel dosing. Circulation. 2005;111:2557–2559
  9. Bliden KP, Chiara J, Tantry US, Bassi AK, Chaganti SK, Burbel PA. Increased risk in patients with high platelet aggregation on chronic clopidogrel therapy undergoing PCI: is the current antiplatelet therapy adequate?. J Am Coll Cardiol. 2007;49:657–666
  10. Gurbel PA, Bliden KP, Tantry US. The effect of clopidogrel with and without eptifibatide on tumor necrosis factor-alpha and C-reactive protein release after elective stenting: results of the CLEAR-PLATELETS-1b study. J Am Coll Cardiol. 2006;48:2186–2189

PII: S0002-9149(08)00646-2

doi: 10.1016/j.amjcard.2008.03.073

American Journal of Cardiology
Volume 102, Issue 4 , Pages 401-403 , 15 August 2008

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