American Journal of Cardiology
Volume 102, Issue 3 , Pages 280-284 , 1 August 2008

Usefulness of Microvolt T-Wave Alternans to Predict Outcomes in Patients With Ischemic Cardiomyopathy Beyond One Year

  • Paul S. Chan, MD, MSc

      Affiliations

    • Mid-America Heart Institute and University of Missouri, Kansas City, Missouri
    • Corresponding Author InformationCorresponding author: Tel: 816-699-3409; fax: 816-932-5744.
    • ,
  • Dean J. Kereiakes, MD

      Affiliations

    • The Lindner Clinical Trial Center at the Christ Hospital and the Ohio Heart and Vascular Center, Cincinnati, Ohio.
    • ,
  • Cheryl Bartone, BS

      Affiliations

    • The Lindner Clinical Trial Center at the Christ Hospital and the Ohio Heart and Vascular Center, Cincinnati, Ohio.
    • ,
  • Theodore Chow, MD

      Affiliations

    • The Lindner Clinical Trial Center at the Christ Hospital and the Ohio Heart and Vascular Center, Cincinnati, Ohio.

Received 8 February 2008 ,Revised 17 March 2008 ,Accepted 17 March 2008.

References 

  1. Bloomfield DM, Steinman RC, Namerow PB, Parides M, Davidenko J, Kaufman ES, et al Microvolt T-wave alternans distinguishes between patients likely and patients not likely to benefit from implanted cardiac defibrillator therapy: a solution to the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II conundrum. Circulation. 2004;110:1885–1889
  2. Hohnloser SH, Ikeda T, Bloomfield DM, Dabbous OH, Cohen RJ. T-wave alternans negative coronary patients with low ejection and benefit from defibrillator implantation. Lancet. 2003;362:125–126
  3. Chow T, Kereiakes DJ, Bartone C, Booth T, Schloss EJ, Waller T, et al. Prognostic utility of microvolt T-wave alternans in risk stratifying patients with ischemic cardiomyopathy. J Am Coll Cardiol. 2006;47:1820–1827
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  7. Bloomfield D, Hohnloser S, Cohen R. Interpretation and classification of microvolt T wave alternans tests. J Cardiovasc Electrophysiol. 2002;13:502–512
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  9. Kaufman ES, Bloomfield DM, Steinman RC, Namerow PB, Costantini O, Cohen RJ, et al. “Indeterminate” microvolt T-wave alternans tests predict high risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction. J Am Coll Cardiol. 2006;48:1399–1404
  10. Chan PS, Nallamothu BK, Chow T. Microvolt T-wave alternans: where do we go from here?. [letter to the editor] J Am Coll Cardiol. 2006;47:1736
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  15. Moss AJ, Zareba W, Hall WJ, Klein H, Wilber DJ, Cannom DS, et al. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med. 2002;346:877–883
  16. Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, et al Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med. 2005;352:225–237

 This study was funded in part by Medtronic, Inc., Minneapolis, Minnesota. Dr. Chan completed part of this study while supported by a Cardiovascular Multidisciplinary Research Training Grant from the National Institutes of Health, Bethesda, Maryland, and by a Ruth L. Kirschstein National Research Service Award from the National Institutes of Health while at the University of Michigan School of Medicine.

PII: S0002-9149(08)00562-6

doi: 10.1016/j.amjcard.2008.03.049

American Journal of Cardiology
Volume 102, Issue 3 , Pages 280-284 , 1 August 2008

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