American Journal of Cardiology
Volume 102, Issue 2 , Pages 135-139 , 15 July 2008

Prognostic Value of Free Plasma Homocysteine Levels in Patients Hospitalized With Acute Coronary Syndrome

  • Martijn G.H. van Oijen, MSc

      Affiliations

    • Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    • Corresponding Author InformationCorresponding author: Tel.: 31-24-361-7272; fax: 31-24-354-0103.
    • ,
  • Bimmer E.P.M. Claessen, MD

      Affiliations

    • Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    • Department of Cardiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
    • ,
  • Nick Clappers, MD

      Affiliations

    • Department of Cardiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
    • ,
  • Annie van Schaik, BSc

      Affiliations

    • Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    • ,
  • Robert J.F. Laheij, MD, PhD

      Affiliations

    • Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    • ,
  • Jan B.M.J. Jansen, MD, PhD

      Affiliations

    • Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    • ,
  • Wilbert H.M. Peters, PhD

      Affiliations

    • Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    • ,
  • Freek W.A. Verheugt, MD, PhD

      Affiliations

    • Department of Cardiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

Received 7 December 2007 ,Revised 4 March 2008 ,Accepted 4 March 2008.

References 

  1. The Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA. 2002;288:2015–2022
  2. Eikelboom JW, Lonn E, Genest J, Hankey G, Yusuf S. Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiologic evidence. Ann Intern Med. 1999;131:363–375
  3. Splaver A, Lamas GA, Hennekens CH. Homocysteine and cardiovascular disease: biological mechanisms, observational epidemiology, and the need for randomized trials. Am Heart J. 2004;148:34–40
  4. Chambers JC, Ueland PM, Wright M, Dore CJ, Refsum H, Kooner JS. Investigation of relationship between reduced, oxidized, and protein-bound homocysteine and vascular endothelial function in healthy human subjects. Circ Res. 2001;89:187–192
  5. Chambers JC, Ueland PM, Obeid OA, Wrigley J, Refsum H, Kooner JS. Improved vascular endothelial function after oral B vitamins: an effect mediated through reduced concentrations of free plasma homocysteine. Circulation. 2000;102:2479–2483
  6. van Oijen MG, Laheij RJ, Peters WH, Jansen JB, Verheugt FW. Association of aspirin use with vitamin B12 deficiency (results of the BACH study). Am J Cardiol. 2004;94:975–977
  7. Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, et al. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med. 2006;354:1567–1577
  8. Raijmakers MT, Zusterzeel PL, Steegers EA, Hectors MP, Demacker PN, Peters WH. Plasma thiol status in preeclampsia. Obstet Gynecol. 2000;95:180–184
  9. Zylberstein DE, Bengtsson C, Björkelund C, Landaas S, Sundh V, Thelle D, et al. Serum homocysteine in relation to mortality and morbidity from coronary heart disease: a 24-year follow-up of the population study of women in Gothenburg. Circulation. 2004;109:601–606
  10. Ueland PM, Refsum H, Stabler SP, Malinow MR, Andersson A, Allen RH. Total homocysteine in plasma or serum: methods and clinical applications. Clin Chem. 1993;39:1764–1779
  11. Bots ML, Launer LJ, Lindemans J, Hoes AW, Hofman A, Witteman JC, et al. Homocysteine and short-term risk of myocardial infarction and stroke in the elderly: the Rotterdam Study. Arch Intern Med. 1999;159:38–44
  12. Ubbink JB, Fehily AM, Pickering J, Elwood PC, Vermaak WJ. Homocysteine and ischaemic heart disease in the Caerphilly cohort. Atherosclerosis. 1998;140:349–356
  13. Stampfer MJ, Malinow MR, Willett WC, Newcomer LM, Upson B, Ullmann D, et al. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA. 1992;268:877–881
  14. Bonaa KH, Njolstad I, Ueland PM, Schirmer H, Tverdal A, Steigen T, et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med. 2006;354:1578–1588
  15. Danesh J, Wheeler JG, Hirschfield GM, Eda S, Eiriksdottir G, Rumley A, et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med. 2004;350:1387–1397
  16. Felker GM, Petersen JW, Mark DB. Natriuretic peptides in the diagnosis and management of heart failure. CMAJ. 2006;175:611–617

PII: S0002-9149(08)00519-5

doi: 10.1016/j.amjcard.2008.03.022

American Journal of Cardiology
Volume 102, Issue 2 , Pages 135-139 , 15 July 2008

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