American Journal of Cardiology
Volume 101, Issue 11, Supplement , Pages S78-S81 , 2 June 2008

Impairment in Walking Capacity and Myocardial Function in the Elderly: Is There a Role for Nonpharmacologic Therapy with Nutritional Amino Acid Supplements?

  • Roldano Scognamiglio, MD

      Affiliations

    • Metabolic Cardiology Unit, Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    • Corresponding Author InformationAddress for reprints: Roldano Scognamiglio, MD, Metabolic Cardiology Unit, Department of Clinical and Experimental Medicine, Polyclinic, via Giustiniani 2, 35100 Padua, Italy.
    • ,
  • Amidio Testa, MD

      Affiliations

    • Rehabilitation Center, Foundation “E. Spalenza-Don Gnocchi,” Rovato, Brescia, Italy
    • ,
  • Roberto Aquilani, MD

      Affiliations

    • Metabolic Service and Nutritional Pathophysiology, Foundation “S. Maugeri,” IRCCS, Scientific Institute of Montescano, Pavia, Italy
    • ,
  • Francesco S. Dioguardi, MD

      Affiliations

    • Department of Internal Medicine, University of Milan, Milan, Italy
    • ,
  • Evasio Pasini, MD

      Affiliations

    • Foundation “Salvatore Maugeri,” IRCCS, Scientific Institute of Lumezzane, Brescia, Italy.

References 

  1. Berkman LF, Seeman TE, Albert M, Blazer D, Kahn R, Mohs R, et al. High, usual and impaired functioning in community-dwelling older men and women: findings from the MacArthur Foundation Research Network on Successful Aging. J Clin Epidemiol. 1993;46:1129–1140
  2. Buchner DM. Physical activity and quality of life in older adults. JAMA. 1997;277:64–66
  3. Volpi E, Ferrando AA, Yeckel CW, Tipton KD, Wolfe RR. Exogenous amino acids stimulate net muscle protein synthesis in the elderly. J Clin Invest. 1998;101:2000–2007
  4. Scognamiglio R, Negut C, Piccoletto R, Dioguardi FS, Tiengo A, Avogaro A. Effects of oral amino acid supplementation on myocardial function in patients with type 2 diabetes mellitus. Am Heart J. 2004;147:1106–1112
  5. Aquilani R, Opasich C, Dossena M, Iadarola P, Gualco A, Arcidiaco P, et al. Increased skeletal muscle amino acid release with light exercise in deconditioned patients with heart failure. J Am Coll Cardiol. 2005;45:158–159
  6. Scognamiglio R, Piccolotto R, Negut C, Tiengo A, Avogaro A. Oral amino acids in elderly subjects: effect on myocardial function and walking capacity. Gerontology. 2005;51:302–308
  7. Binder EF, Schechtman KB, Ehsani AA, Stegen-May K, Brown M, Sinacore DR, et al. Effects of exercise training on frailty in community-dwelling older adults: results of a randomized, controlled trial. J Am Geriatr Soc. 2002;50:1921–1928
  8. King AC, Rejeski WJ, Buchner DM. Physical activity interventions targeting older adults: a critical review and recommendation. Am J Prev Med. 1998;15:316–333
  9. Stessman J, Hammerman-Rozenberg R, Maaravi Y, Cohen A. Effect of exercise on ease in performing activities of daily living and instrumental activities of daily living from age 70 to 77: the Jerusalem Longitudinal Study. J Am Geriatr Soc. 2002;50:1934–1938
  10. Pickering GP, Fellmann N, Morio B, Ritz P, Amonchot A, Vermorel M, et al. Effects of endurance training on the cardiovascular system and water compartments in elderly subjects. J Appl Physiol. 1997;83:1300–1306

 Statement of author disclosure: Please see the Author Disclosures section at the end of this article.

PII: S0002-9149(08)00400-1

doi: 10.1016/j.amjcard.2008.03.005

American Journal of Cardiology
Volume 101, Issue 11, Supplement , Pages S78-S81 , 2 June 2008

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