American Journal of Cardiology
Volume 101, Issue 8 , Pages 1073-1078 , 15 April 2008

Baseline Plasma Adiponectin Levels as a Predictor of Left Ventricular Systolic Dysfunction in Patients Referred for Coronary Angiography

  • Erdal Cavusoglu, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, State University of New York Health Science Center at Brooklyn, New York
    • Department of Medicine, Division of Cardiology, Bronx Veterans Affairs Medical Center, Bronx, New York
    • Corresponding Author InformationCorresponding author: Tel: 718-270-7352; Fax: 917-677-4794.
    • ,
  • Vineet Chopra, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, Bronx Veterans Affairs Medical Center, Bronx, New York
    • ,
  • Venkata Battala, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, State University of New York Health Science Center at Brooklyn, New York
    • ,
  • Cyril Ruwende, MD, PhD

      Affiliations

    • Department of Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan.
    • ,
  • Sunitha Yanamadala, PhD

      Affiliations

    • Department of Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan.
    • ,
  • Calvin Eng, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, Bronx Veterans Affairs Medical Center, Bronx, New York
    • ,
  • David J. Pinsky, MD

      Affiliations

    • Department of Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan.
    • ,
  • Jonathan D. Marmur, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, State University of New York Health Science Center at Brooklyn, New York

Received 19 October 2007 ,Revised 9 December 2007 ,Accepted 9 December 2007.

References 

  1. Cavusoglu E, Ruwende C, Chopra V, Yanamadala S, Eng C, Clark LT, et al. Adiponectin is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction in patients presenting with chest pain. Eur Heart J. 2006;27:2300–2309
  2. Menon V, Li L, Wang X, Greene T, Balakrishnan V, Madero M, et al. Adiponectin and mortality in patients with chronic kidney disease. J Am Soc Nephrol. 2006;17:2599–2606
  3. Pilz S, Mangge H, Wellnitz B, Seelhorst U, Winkelmann BR, Tiran B, et al. Adiponectin and mortality in patients undergoing coronary angiography. J Clin Endocrinol Metab. 2006;91:4277–4286
  4. Kistorp C, Faber J, Galatius S, Gustafsson F, Frystyk J, Flyvbjerg A, et al. Plasma adiponectin, body mass index, and mortality in patients with chronic heart failure. Circulation. 2005;112:1756–1762
  5. George J, Patal S, Wexler D, Sharabi Y, Peleg E, Kamari Y, et al. Circulating adiponectin concentrations in patients with congestive heart failure. Heart. 2006;92:1420–1424
  6. Kojima S, Funahashi T, Sakamoto T, Miyamoto S, Soejima H, Hokamaki J, et al The variation of plasma concentrations of a novel, adipocyte derived protein, adiponectin, in patients with acute myocardial infarction. Heart. 2003;89:667
  7. Shibata R, Sato K, Kumada M, Izumiya Y, Sonoda M, Kihara S, et al. Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular compartment. Cardiovasc Res. 2007;74:471–479
  8. Ouchi N, Shibata R, Walsh K. Cardioprotection by adiponectin. Trends Cardiovasc Med. 2006;16:141–146
  9. Liao Y, Takashima S, Maeda N, Ouchi N, Komamura K, Shimomura I, et al. Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism. Cardiovasc Res. 2005;67:705–713
  10. Shibata R, Ouchi N, Ito M, Kihara S, Shiojima I, Pimentel DR, et al Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med. 2004;10:1384–1389
  11. Shibata R, Izumiya Y, Sato K, Papanicolaou K, Kihara S, Colucci WS, et al. Adiponectin protects against the development of systolic dysfunction following myocardial infarction. J Mol Cell Cardiol. 2007;42:1065–1074
  12. Tsutamoto T, Tanaka T, Sakai H, Ishikawa C, Fujii M, Yamamoto T, et al. Total and high molecular weight adiponectin, haemodynamics, and mortality in patients with chronic heart failure. Eur Heart J. 2007;28:1723–1730
  13. Trujillo ME, Scherer PE. Adiponectin—journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med. 2005;257:167–175
  14. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, et al Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun. 1999;257:79–83

PII: S0002-9149(07)02448-4

doi: 10.1016/j.amjcard.2007.12.008

American Journal of Cardiology
Volume 101, Issue 8 , Pages 1073-1078 , 15 April 2008

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